PMID- 32516544
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20220417
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 93
IP  - 1114
DP  - 2020 Oct 1
TI  - Impact of dosimetric differences between CT and MRI derived target volumes for 
      external beam cervical cancer radiotherapy.
PG  - 20190564
LID - 10.1259/bjr.20190564 [doi]
LID - 20190564
AB  - OBJECTIVES: The use of MRI is becoming more prevalent in cervical cancer external 
      beam radiotherapy (RT). The aim of this study was to investigate the impact of 
      dosimetric differences between CT and MRI-derived target volumes for cervical 
      cancer external beam RT. METHODS: An automated planning technique for volumetric 
      modulated arc therapy was developed. Two automated planning plans were generated 
      for 18 cervical cancer patients where planning target volumes (PTVs) were 
      generated based on CT or MRI data alone. Dose metrics for planning target volumes 
      and organs at risk (OARs) were compared to analyse any differences based on 
      imaging modality. RESULTS: All treatment plans were clinically acceptable. 
      Bladder doses (V40) were lower in MRI-based plans (p = 0.04, 53.6 +/- 17.2 % vs 
      60.3 +/- 13.1 % for MRI vs CT, respectively). The maximum dose for left iliac crest 
      showed lower doses in CT-based plans (p = 0.02, 47.8 +/- 0.7 Gy vs 47.4 +/- 0.4 Gy 
      MRI vs CT, respectively). No significant differences were seen for other OARs. 
      CONCLUSIONS: The dosimetric differences of CT- and MRI-based contouring 
      variability for this study was small. CT remains the standard imaging modality 
      for volume delineation for these patients. ADVANCES IN KNOWLEDGE: This is the 
      first study to evaluate the dosimetric implications of imaging modality on target 
      and OAR doses in cervical cancer external beam RT.
FAU - Batumalai, Vikneswary
AU  - Batumalai V
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
AD  - Ingham Institute for Applied Medical Research, New South Wales, Australia.
AD  - South Western Clinical School, University of New South Wales, New South Wales, 
      Australia.
FAU - Burke, Siobhan
AU  - Burke S
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
FAU - Roach, Dale
AU  - Roach D
AD  - Ingham Institute for Applied Medical Research, New South Wales, Australia.
AD  - South Western Clinical School, University of New South Wales, New South Wales, 
      Australia.
FAU - Lim, Karen
AU  - Lim K
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
AD  - South Western Clinical School, University of New South Wales, New South Wales, 
      Australia.
FAU - Dinsdale, Glen
AU  - Dinsdale G
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
FAU - Jameson, Michael
AU  - Jameson M
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
AD  - Ingham Institute for Applied Medical Research, New South Wales, Australia.
AD  - South Western Clinical School, University of New South Wales, New South Wales, 
      Australia.
AD  - Centre for Medical Radiation Physics, University of Wollongong, New South Wales, 
      Australia.
FAU - Ochoa, Cesar
AU  - Ochoa C
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
FAU - Veera, Jacqueline
AU  - Veera J
AD  - Peter MaCallum Cancer Centre, Victoria, Australia.
FAU - Holloway, Lois
AU  - Holloway L
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
AD  - Ingham Institute for Applied Medical Research, New South Wales, Australia.
AD  - South Western Clinical School, University of New South Wales, New South Wales, 
      Australia.
AD  - Centre for Medical Radiation Physics, University of Wollongong, New South Wales, 
      Australia.
AD  - Institute of Medical Physics, School of Physics, University of Sydney, New South 
      Wales, Australia.
FAU - Vinod, Shalini
AU  - Vinod S
AD  - Department of Radiation Oncology, South Western Sydney Local Health District, New 
      South Wales, Australia.
AD  - Ingham Institute for Applied Medical Research, New South Wales, Australia.
AD  - South Western Clinical School, University of New South Wales, New South Wales, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20200618
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Organs at Risk/radiation effects
MH  - Radiometry
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - *Tomography, X-Ray Computed
MH  - Uterine Cervical Neoplasms/*diagnostic imaging/*radiotherapy
PMC - PMC7548354
EDAT- 2020/06/10 06:00
MHDA- 2020/10/07 06:00
PMCR- 2021/10/01
CRDT- 2020/06/10 06:00
PHST- 2020/06/10 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2020/06/10 06:00 [entrez]
PHST- 2021/10/01 00:00 [pmc-release]
AID - 10.1259/bjr.20190564 [doi]
PST - ppublish
SO  - Br J Radiol. 2020 Oct 1;93(1114):20190564. doi: 10.1259/bjr.20190564. Epub 2020 
      Jun 18.