PMID- 32516639
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20201221
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 90
DP  - 2020 Sep-Oct
TI  - Early-adulthood caloric restriction is beneficial to improve renal redox status 
      as future anti-aging strategy in rats.
PG  - 104116
LID - S0167-4943(20)30110-2 [pii]
LID - 10.1016/j.archger.2020.104116 [doi]
AB  - AIMS: Caloric restriction (CR) is an experimental approach proposed to alleviate 
      age-related oxidative damage. In the present study, we investigated the 
      consequences of CR on renal redox homeostasis in rats at a specific time frame in 
      early-adulthood.. METHODS: Three groups of male Sprague-Dawley rats; young 
      control at 6-month-old, 2-year-old subjected to 40% CR between 18(th)-24(th) 
      months of age, and their non-CR controls were sacrificed, and numerous redox 
      status biomarkers including protein oxidation, glycation, lipid peroxidation, 
      glycation end products, thiol groups, and superoxide dismutase were assayed. It 
      was also ensured that CR rats and their non-CR corresponding rats had similar 
      body weights at the end of the study to decrease the confounding effects of 
      different body weights on redox homeostasis and caloric restriction. RESULTS: 
      After CR, the detrimental effects of the protein oxidation, glycation, and lipid 
      peroxidation were significantly improved in the renal tissue CR rats when 
      compared to their non-CR control group. However, there were no significant 
      difference in thiol fractions between younger controls and both of the elderly 
      groups. CONCLUSION: Detrimental consequences of renal senescence on redox 
      homeostasis are significantly improved via CR especially applied in 
      early-adulthood.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Dag, Akif Dursun
AU  - Dag AD
AD  - Institute of Health Sciences, Istanbul Okan University, 34394, Istanbul, Turkey.
FAU - Yanar, Karolin
AU  - Yanar K
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Medical Biochemistry, 34096, Istanbul, Turkey.
FAU - Atayik, Mehmet Can
AU  - Atayik MC
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Medical Program, 
      34096, Istanbul, Turkey.
FAU - Simsek, Bahadir
AU  - Simsek B
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Medical Program, 
      34096, Istanbul, Turkey.
FAU - Belce, Ahmet
AU  - Belce A
AD  - Biruni University, School of Medicine, Department of Medical Biochemistry, 34020, 
      Istanbul, Turkey.
FAU - Cakatay, Ufuk
AU  - Cakatay U
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Medical Biochemistry, 34096, Istanbul, Turkey. Electronic address: 
      ufuk.cakatay@istanbul.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20200523
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging
MH  - Animals
MH  - *Caloric Restriction
MH  - Humans
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - aging
OT  - caloric restriction
OT  - kidney
OT  - oxidative damage
OT  - redox homeostasis
EDAT- 2020/06/10 06:00
MHDA- 2020/12/22 06:00
CRDT- 2020/06/10 06:00
PHST- 2020/02/26 00:00 [received]
PHST- 2020/04/01 00:00 [revised]
PHST- 2020/04/20 00:00 [accepted]
PHST- 2020/06/10 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2020/06/10 06:00 [entrez]
AID - S0167-4943(20)30110-2 [pii]
AID - 10.1016/j.archger.2020.104116 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2020 Sep-Oct;90:104116. doi: 
      10.1016/j.archger.2020.104116. Epub 2020 May 23.