PMID- 32517149
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 6
DP  - 2020 Jun 5
TI  - Ratio of IL-8 in CSF versus Serum Is Elevated in Patients with Unruptured Brain 
      Aneurysm.
LID - 10.3390/jcm9061761 [doi]
LID - 1761
AB  - Only scarce data pertaining to interleukin 8 (IL-8) and monocyte chemoattractant 
      protein-1 (MCP-1) chemokines in human aneurysm can be found in the current 
      literature. Therefore, the aim of this study was the evaluation of cerebrospinal 
      fluid (CSF) and serum IL-8 and MCP-1 concentration in unruptured intracranial 
      aneurysm (UIA) patients (n = 25) compared to the control group (n = 20). IL-8 and 
      MCP-1 concentrations were measured with ELISA method. We demonstrated that CSF 
      IL-8 concentration of UIA patients is significantly higher (p < 0.001) than that 
      presented in the serum, which can indicate its local synthesis within central 
      nervous system. CSF IL-8 concentration was also significantly related to aneurysm 
      size, which may reflect the participation of IL-8 in the formation and 
      development of brain aneurysms. IL-8 Quotient (CSF IL-8 divided by serum IL-8) in 
      UIA patients was statistically higher compared to control individuals (p = 
      0.045). However, the diagnostic utility analysis did not equivocally indicate the 
      diagnostic usefulness of the IL-8 Quotient evaluation in brain aneurysm patients. 
      Nevertheless, this aspect requires further study.
FAU - Kaminska, Joanna
AU  - Kaminska J
AD  - Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 15A St., 15-269 Bialystok, Poland.
FAU - Lyson, Tomasz
AU  - Lyson T
AD  - Department of Neurosurgery, Clinical Hospital of the Medical University of 
      Bialystok, M. Sklodowskiej-Curie 24A St., 15-276 Bialystok, Poland.
FAU - Chrzanowski, Robert
AU  - Chrzanowski R
AD  - Department of Neurosurgery, Clinical Hospital of the Medical University of 
      Bialystok, M. Sklodowskiej-Curie 24A St., 15-276 Bialystok, Poland.
FAU - Sawicki, Karol
AU  - Sawicki K
AD  - Department of Neurosurgery, Clinical Hospital of the Medical University of 
      Bialystok, M. Sklodowskiej-Curie 24A St., 15-276 Bialystok, Poland.
FAU - Milewska, Anna J
AU  - Milewska AJ
AD  - Department of Statistics and Medical Informatics, Medical University of 
      Bialystok, ul. Szpitalna 37, 15-295 Bialystok, Poland.
FAU - Tylicka, Marzena
AU  - Tylicka M
AD  - Department of Biophysics, Medical University of Bialystok, Mickiewicza 2A St., 
      15-089 Bialystok, Poland.
FAU - Zinczuk, Justyna
AU  - Zinczuk J
AD  - Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 15A St., 15-269 Bialystok, Poland.
FAU - Matowicka-Karna, Joanna
AU  - Matowicka-Karna J
AD  - Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 15A St., 15-269 Bialystok, Poland.
FAU - Dymicka-Piekarska, Violetta
AU  - Dymicka-Piekarska V
AD  - Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 15A St., 15-269 Bialystok, Poland.
FAU - Mariak, Zenon
AU  - Mariak Z
AD  - Department of Neurosurgery, Clinical Hospital of the Medical University of 
      Bialystok, M. Sklodowskiej-Curie 24A St., 15-276 Bialystok, Poland.
FAU - Koper-Lenkiewicz, Olga M
AU  - Koper-Lenkiewicz OM
AD  - Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 15A St., 15-269 Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20200605
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7356854
OTO - NOTNLM
OT  - IL8/CXCL8-interleukin 8/C-X-C motif chemokine ligand 8
OT  - MCP-1/CCL2- monocyte chemoattractant protein-1/C-C motif ligand 2
OT  - cerebrospinal fluid
OT  - unruptured intracranial aneurysm (UIA)
COIS- The authors declare no conflict of interest.
EDAT- 2020/06/11 06:00
MHDA- 2020/06/11 06:01
PMCR- 2020/06/05
CRDT- 2020/06/11 06:00
PHST- 2020/04/30 00:00 [received]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/06/04 00:00 [accepted]
PHST- 2020/06/11 06:00 [entrez]
PHST- 2020/06/11 06:00 [pubmed]
PHST- 2020/06/11 06:01 [medline]
PHST- 2020/06/05 00:00 [pmc-release]
AID - jcm9061761 [pii]
AID - jcm-09-01761 [pii]
AID - 10.3390/jcm9061761 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jun 5;9(6):1761. doi: 10.3390/jcm9061761.