PMID- 32517418
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 17
IP  - 6
DP  - 2020 Jun
TI  - Comparison of Amyloid Positivity Rate and Accumulation Pattern between Amnestic 
      and Non-Amnestic Type Mild Cognitive Impairment.
PG  - 603-607
LID - 10.30773/pi.2020.0063 [doi]
AB  - OBJECTIVE: We aimed to compare cerebral beta-amyloid protein (Abeta) positivity rate 
      and amyloid accumulation pattern on amyloid positron emission tomography (PET) 
      between mild cognitive impairment (MCI) subtypes, i.e. amnestic mild cognitive 
      impairment (aMCI) and non-amnestic mild cognitive impairment (naMCI). METHODS: 
      The study participants were 34 naMCI patients and age-, sex- and 
      education-matched 68 aMCI patients (1:2 ratio) who visited the Dementia and 
      Age-Associated Cognitive Decline Clinic of the Seoul National University 
      Hospital. All participants received comprehensive clinical and neuropsychological 
      assessments and [(18)F] florbetaben PET. RESULTS: Abeta positivity rate of naMCI 
      group (26.5%) was significantly lower than that of aMCI group (64.7%). Among Abeta 
      positive individuals, there was no difference in Abeta accumulation pattern between 
      naMCI and aMCI. CONCLUSION: The findings suggest that MCI subtypes based on 
      impaired cognitive domains have a differential association with brain Abeta 
      deposition, a core pathology of AD. Amnestic subtype of MCI are more closely 
      associated with cerebral Abeta deposition compared to nonamnestic subtype. In 
      contrast, the pattern of amyloid deposition does not appear to have any 
      difference between the subtypes.
FAU - Lee, Sun Hyung
AU  - Lee SH
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
FAU - Lee, Jun Ho
AU  - Lee JH
AD  - Department of Neuropsychiatry, National Center for Mental Health, Seoul, Republic 
      of Korea.
FAU - Byun, Min Soo
AU  - Byun MS
AD  - Department of Neuropsychiatry, Seoul National University Bundang Hospital, 
      Seongnam, Republic of Korea.
FAU - Yi, Dahyun
AU  - Yi D
AD  - Institute of Human Behavioral Medicine, Medical Research Center, Seoul National 
      University, Seoul, Republic of Korea.
FAU - Jung, Gijung
AU  - Jung G
AD  - Institute of Human Behavioral Medicine, Medical Research Center, Seoul National 
      University, Seoul, Republic of Korea.
AD  - Department of Nursing, Graduate School, Kyung Hee University, Seoul, Republic of 
      Korea.
FAU - Park, Jee Eun
AU  - Park JE
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Dong Young
AU  - Lee DY
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Institute of Human Behavioral Medicine, Medical Research Center, Seoul National 
      University, Seoul, Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
LA  - eng
GR  - 2014M3C7A1046042/Ministry of Science and Technology/
GR  - Korea Health Industry Development Institute/
GR  - HI18C0630/Ministry of Health and Welfare/
GR  - HI19C0149/Ministry of Health and Welfare/
PT  - Journal Article
DEP - 20200611
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC7324742
OTO - NOTNLM
OT  - Amnestic MCI
OT  - Amyloid PET
OT  - Amyloid accumulation pattern
OT  - Amyloid positivity rate
OT  - Non-amnestic MCI
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2020/06/11 06:00
MHDA- 2020/06/11 06:01
PMCR- 2020/06/01
CRDT- 2020/06/11 06:00
PHST- 2020/02/17 00:00 [received]
PHST- 2020/04/03 00:00 [accepted]
PHST- 2020/06/11 06:00 [pubmed]
PHST- 2020/06/11 06:01 [medline]
PHST- 2020/06/11 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - pi.2020.0063 [pii]
AID - pi-2020-0063 [pii]
AID - 10.30773/pi.2020.0063 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2020 Jun;17(6):603-607. doi: 10.30773/pi.2020.0063. Epub 
      2020 Jun 11.