PMID- 32518647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2049-0801 (Print)
IS  - 2049-0801 (Electronic)
IS  - 2049-0801 (Linking)
VI  - 55
DP  - 2020 Jul
TI  - Enucleated globes with choroidal melanoma: A retrospective histopathological 
      study and correlation with cytogenetic profile in 2 eye centers.
PG  - 227-233
LID - 10.1016/j.amsu.2020.05.003 [doi]
AB  - BACKGROUND: Uveal melanoma is the commonest intraocular malignant tumor in adults 
      and the choroid is the commonest involved location. It is more prevalent in 
      Caucasians; however, the demographics are widely variable based on ethnicity. 
      Histopathological features have been correlated to the cytogenetic profile, which 
      we intend to report through the study of enucleated eyes with choroidal melanoma 
      (CM). MATERIALS AND METHODS: A retrospective review of 28 enucleated globes with 
      CM in 2 tertiary eye centers (January 2000-December 2017). The tumors were 
      histopathologically classified based on the 8th edition of the American Joint 
      Committee on Cancer (AJCC). The histopathological risk factors and the AJCC 
      classifications were correlated with Fluorescence in situ hybridization (FISH) 
      for chromosomes 3 and 8 available results in 18/28 eyes. RESULTS: We have 
      included 28 patients with a mean age of 56 years, 13 males (46.4%) and 15 females 
      (53.6%). None had lymph node involvement or metastatic disease. The tumor size 
      was categorized as 3 and 4 in 68% of eyes. Half tumors were of spindle cell type 
      and were associated with absent cytogenetic abnormality in chromosomes 3 and 8 
      (P=0.005). Closed vascular loops presence was significantly associated with 
      abnormal chromosomes 3 and 8 (P=0.027). CONCLUSION: Patients in our area 
      presented late with larger tumor size. The spindle cell CM was the commonest and 
      correlated with negative FISH results, while the presence of closed vascular 
      loops was a risk factor for abnormal FISH results hence expected worse prognosis. 
      AJCC classification did not correlate well with our FISH results.
CI  - (c) 2020 The Author(s).
FAU - Alkatan, Hind M
AU  - Alkatan HM
AD  - Ophthalmology Department, King Saud University Riyadh, Saudi Arabia.
AD  - Pathology Department, King Saud University, Riyadh, Saudi Arabia.
FAU - Al Qahtani, Abdullah Aoun
AU  - Al Qahtani AA
AD  - Surgical Vitreo-retina, Ophthalmology Department, Imam Abdulrahman Bin Faisal 
      University, Dammam, Saudi Arabia.
FAU - Maktabi, Azza My
AU  - Maktabi AM
AD  - Pathology & Laboratory Medicine Department, King Khaled Eye Specialist Hospital, 
      Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20200601
PL  - England
TA  - Ann Med Surg (Lond)
JT  - Annals of medicine and surgery (2012)
JID - 101616869
PMC - PMC7272512
OTO - NOTNLM
OT  - Choroidal melanoma
OT  - Chromosome
OT  - Cytogenetic
OT  - Enucleation
OT  - Histopathology
COIS- The authors have no conflict of interest or financial disclosures in relation to 
      this work.
EDAT- 2020/06/11 06:00
MHDA- 2020/06/11 06:01
PMCR- 2020/06/01
CRDT- 2020/06/11 06:00
PHST- 2020/03/24 00:00 [received]
PHST- 2020/04/30 00:00 [revised]
PHST- 2020/05/04 00:00 [accepted]
PHST- 2020/06/11 06:00 [entrez]
PHST- 2020/06/11 06:00 [pubmed]
PHST- 2020/06/11 06:01 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - S2049-0801(20)30089-3 [pii]
AID - 10.1016/j.amsu.2020.05.003 [doi]
PST - epublish
SO  - Ann Med Surg (Lond). 2020 Jun 1;55:227-233. doi: 10.1016/j.amsu.2020.05.003. 
      eCollection 2020 Jul.