PMID- 32519199
OWN - NLM
STAT- MEDLINE
DCOM- 20211011
LR  - 20211011
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 44
IP  - 2
DP  - 2021 Feb
TI  - Association of MICA gene polymorphisms with thionamide-induced agranulocytosis.
PG  - 363-369
LID - 10.1007/s40618-020-01319-0 [doi]
AB  - BACKGROUND: Thionamide-induced agranulocytosis (TIA), namely antithyroid drug 
      (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. 
      It is defined as a granulocyte count of less than 0.5 x 10(9)/L after ATD 
      administration. Several studies reported that TIA is associated with human 
      leukocyte antigen (HLA) and nearby genes. Our previous study found that the 
      susceptibility genes of TIA are similar in north China and European populations. 
      METHODS: We evaluated the associations of 23 candidate single nucleotide 
      polymorphisms (SNPs) in 37 patients with TIA and 254 patients with Graves' 
      disease (GD) as controls by iPLEX MassARRAY system. RESULTS: Five SNPs in the MHC 
      class I polypeptide-related sequence A(MICA) genes [rs4349859 (p = 1.43E-7); 
      rs145575084 (p = 5.79E-6); rs116135464 (p = 3.70E-5); rs148015908 (p = 3.79E-5) 
      and rs189600525 (p = 2.15E-4)] were found to be significantly associated with TIA 
      after Bonferroni correction. After combining with previous data of rs4349859 and 
      HLA-B*27:05, the haplotype analysis showed that patients carrying P-A-C-A-T-T-A 
      haplotype have a higher risk of TIA (p = 9.76E-7; OR = 14.85, 95% CI 3.63-60.77). 
      CONCLUSION: Our findings suggest that five high linked SNPs of MICA gene are 
      significantly associated with susceptibility to TIA.
FAU - Ma, P
AU  - Ma P
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Chen, P
AU  - Chen P
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Gao, J
AU  - Gao J
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Guo, H
AU  - Guo H
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Li, S
AU  - Li S
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Yang, J
AU  - Yang J
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Lai, J
AU  - Lai J
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Yang, X
AU  - Yang X
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China.
FAU - Zhang, B
AU  - Zhang B
AUID- ORCID: 0000-0003-0320-2305
AD  - College of Medicine and Forensic, Health Science Center, Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China. 
      zhangbao_814@mail.xjtu.edu.cn.
FAU - He, Y
AU  - He Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, People's Republic of China. heyayi205334@126.com.
LA  - eng
GR  - 2018YFC1314800/National Key R&D Program of China/
GR  - 2017JQ8010; 2017SF-171/Shaanxi Provincial Natural Science Foundation of China/
GR  - No.31301949/National Natural Science Foundation of China/
GR  - xjj2017135/Fundamental Research Funds for the Central Universities/
PT  - Journal Article
DEP - 20200609
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Antithyroid Agents)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adult
MH  - Agranulocytosis/chemically induced/epidemiology/genetics/*pathology
MH  - Antithyroid Agents/*adverse effects
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Genetic Predisposition to Disease
MH  - Graves Disease/*drug therapy
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
OTO - NOTNLM
OT  - Association
OT  - Graves' disease
OT  - MICA
OT  - Thionamide-induced agranulocytosis
EDAT- 2020/06/11 06:00
MHDA- 2021/10/12 06:00
CRDT- 2020/06/11 06:00
PHST- 2019/12/03 00:00 [received]
PHST- 2020/05/29 00:00 [accepted]
PHST- 2020/06/11 06:00 [pubmed]
PHST- 2021/10/12 06:00 [medline]
PHST- 2020/06/11 06:00 [entrez]
AID - 10.1007/s40618-020-01319-0 [pii]
AID - 10.1007/s40618-020-01319-0 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2021 Feb;44(2):363-369. doi: 10.1007/s40618-020-01319-0. 
      Epub 2020 Jun 9.