PMID- 32521479 OWN - NLM STAT- MEDLINE DCOM- 20210222 LR - 20210702 IS - 1618-131X (Electronic) IS - 1438-4639 (Print) IS - 1438-4639 (Linking) VI - 228 DP - 2020 Jul TI - Prenatal exposure to a mixture of persistent organic pollutants (POPs) and child reading skills at school age. PG - 113527 LID - S1438-4639(19)30903-4 [pii] LID - 10.1016/j.ijheh.2020.113527 [doi] AB - BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) may affect child neurobehavior; however, exposures to mixtures of POPs have rarely been examined. METHODS: We estimated associations of prenatal serum concentrations of 17 POPs, namely 5 polybrominated diphenyl ethers (PBDEs), 6 polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), dichlorodiphenyltrichloroethane (DDT), and 4 per- and polyfluoroalkyl substances (PFAS), with Wide Range Achievement Test-4 reading composite scores at age 8 years in 161 children from a pregnancy and birth cohort (Health Outcomes and Measures of the Environment [HOME] Study, 2003-present) in Cincinnati, OH. We applied 6 statistical methods: least absolute shrinkage and selection operator (LASSO), elastic net (ENET), Sparse Principal Component Analysis (SPCA), Weighted Quantile Sum (WQS) regression, Bayesian Kernel Machine Regression (BKMR), and Bayesian Additive Regression Trees (BART), to estimate covariate-adjusted associations with individual and their mixtures in multi-pollutant models. RESULTS: Both LASSO and ENET models indicated inverse associations with reading scores for BDE-153 and BDE-28, and positive associations for CB-118, CB-180, perfluoroctanoate (PFOA), and perfluorononanoate (PFNA). The SPCA identified inverse associations for BDE-153 and BDE-100 and positive associations for perfluorooctane sulfonate (PFOS), PFOA, and PFNA, as parts of different principal component scores. The WQS regression showed the highest weights for BDE-100 (0.35) and BDE-28 (0.16) in the inverse association model and for PFNA (0.29) and CB-180 (0.21) in the positive association model. The BKMR model identified BDE-100 and BDE-153 for inverse associations and CB-118, CB-153, CB-180, PFOA, and PFNA for positive associations. The BART method found dose-response functions similar to the BKMR model. No interactions between POPs were identified. CONCLUSIONS: Despite some inconsistency among biomarkers, these analyses revealed inverse associations between prenatal PBDE concentrations and children's reading scores. Positive associations of PCB congeners and PFAS with reading skills were also found. CI - Copyright (c) 2020 Elsevier GmbH. All rights reserved. FAU - Vuong, Ann M AU - Vuong AM AD - Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Department of Environmental and Occupational Health, University of Nevada Las Vegas, School of Public Health, United States. FAU - Xie, Changchun AU - Xie C AD - Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States. FAU - Jandarov, Roman AU - Jandarov R AD - Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States. FAU - Dietrich, Kim N AU - Dietrich KN AD - Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States. FAU - Zhang, Hongmei AU - Zhang H AD - Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi Province, China. FAU - Sjodin, Andreas AU - Sjodin A AD - National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States. FAU - Calafat, Antonia M AU - Calafat AM AD - National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States. FAU - Lanphear, Bruce P AU - Lanphear BP AD - Child and Family Research Institute, BC Children's Hospital, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada. FAU - McCandless, Lawrence AU - McCandless L AD - Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada. FAU - Braun, Joseph M AU - Braun JM AD - Department of Epidemiology, Brown University, Providence, RI, United States. FAU - Yolton, Kimberly AU - Yolton K AD - Department of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. FAU - Chen, Aimin AU - Chen A AD - Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: Aimin.Chen@Pennmedicine.upenn.edu. LA - eng GR - R00 ES020346/ES/NIEHS NIH HHS/United States GR - P01 ES011261/ES/NIEHS NIH HHS/United States GR - P30 ES006096/ES/NIEHS NIH HHS/United States GR - R01 ES014575/ES/NIEHS NIH HHS/United States GR - R01 ES028277/ES/NIEHS NIH HHS/United States GR - R01 ES024381/ES/NIEHS NIH HHS/United States GR - R01 ES025214/ES/NIEHS NIH HHS/United States GR - T32 ES010957/ES/NIEHS NIH HHS/United States GR - R01 ES020349/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20200607 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Fluorocarbons) RN - 0 (Halogenated Diphenyl Ethers) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - CIW5S16655 (DDT) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adult MH - Child MH - DDT/blood MH - Dichlorodiphenyl Dichloroethylene/blood MH - Female MH - Fluorocarbons/blood MH - Halogenated Diphenyl Ethers/blood MH - Humans MH - *Maternal Exposure MH - *Persistent Organic Pollutants/blood MH - Polychlorinated Biphenyls/blood MH - Pregnancy/blood MH - *Prenatal Exposure Delayed Effects MH - *Reading PMC - PMC7328128 MID - NIHMS1601949 OTO - NOTNLM OT - Chemical mixtures OT - Neurodevelopment OT - Persistent organic pollutants (POPs) OT - Polybrominated diphenyl ethers (PBDEs) OT - Polychlorinated biphenyls (PCBs) OT - dichlorodiphenyldichloroethylene (DDE) OT - dichlorodiphenyltrichloroethane (DDT) OT - per- and polyfluoroalkyl substances (PFAS) EDAT- 2020/06/11 06:00 MHDA- 2021/02/23 06:00 PMCR- 2021/07/01 CRDT- 2020/06/11 06:00 PHST- 2019/10/15 00:00 [received] PHST- 2020/04/04 00:00 [revised] PHST- 2020/04/11 00:00 [accepted] PHST- 2020/06/11 06:00 [pubmed] PHST- 2021/02/23 06:00 [medline] PHST- 2020/06/11 06:00 [entrez] PHST- 2021/07/01 00:00 [pmc-release] AID - S1438-4639(19)30903-4 [pii] AID - 10.1016/j.ijheh.2020.113527 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2020 Jul;228:113527. doi: 10.1016/j.ijheh.2020.113527. Epub 2020 Jun 7.