PMID- 32522082
OWN - NLM
STAT- MEDLINE
DCOM- 20211006
LR  - 20211006
IS  - 1931-8448 (Electronic)
IS  - 1076-6294 (Linking)
VI  - 27
IP  - 1
DP  - 2021 Jan
TI  - Methylsulfonylmethane Exhibits Bacteriostatic Inhibition of Vancomycin-Resistant 
      Enterococcus faecium, In Vitro.
PG  - 13-17
LID - 10.1089/mdr.2019.0454 [doi]
AB  - The aim of this study was to evaluate the antibacterial properties of 
      methylsulfonylmethane (MSM) on vancomycin-resistant Enterococcus faecium (VRE). 
      Bacterial proliferation was measured spectrophotometrically during growth in 
      brain heart infusion broth with 0%, 3%, 5%, 7%, 10%, 12%, and 16% MSM. To assess 
      the mechanism of inhibition, VRE was grown overnight with 0-16% MSM and 
      enumerated on unmedicated and medicated (3-16% MSM) brain heart infusion agar 
      (BHIA). Viability studies were performed to evaluate the impact of 10-16% MSM on 
      VRE over 7 days. Absorbance data indicated a dose-dependent inhibition from 0% to 
      7% MSM and no increase in optical density in 10-16% MSM. VRE enumerated on 
      unmedicated BHIA from overnight cultures with 10-16% MSM partially recovered. No 
      growth was observed when BHIA contained 10-16% MSM. There was little effect on 
      VRE growth in 10% MSM over 7 days. VRE displayed a population rebound on day 6 
      when exposed to 12% MSM, and elimination by day 6 in 16% MSM. Regrowth after MSM 
      removal may be indicative of a bacteriostatic mechanism of inhibition. Cell 
      elimination in 16% MSM suggests inhibition of an essential metabolic function 
      from which the bacterium could not recover.
FAU - Poole, Toni L
AU  - Poole TL
AD  - USDA, Agricultural Research Service, Plains Agricultural Research Center, College 
      Station, Texas, USA.
FAU - Benjamin, Rodney
AU  - Benjamin R
AD  - Bergstrom Nutrition, Vancouver, Washington, USA.
FAU - Genovese, Kenneth J
AU  - Genovese KJ
AD  - USDA, Agricultural Research Service, Plains Agricultural Research Center, College 
      Station, Texas, USA.
FAU - Nisbet, David J
AU  - Nisbet DJ
AD  - USDA, Agricultural Research Service, Plains Agricultural Research Center, College 
      Station, Texas, USA.
LA  - eng
PT  - Journal Article
DEP - 20200609
PL  - United States
TA  - Microb Drug Resist
JT  - Microbial drug resistance (Larchmont, N.Y.)
JID - 9508567
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Sulfones)
RN  - 9H4PO4Z4FT (dimethyl sulfone)
RN  - YOW8V9698H (Dimethyl Sulfoxide)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Dimethyl Sulfoxide/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Enterococcus faecium/*drug effects
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Sulfones/*pharmacology
MH  - Vancomycin-Resistant Enterococci/*drug effects
OTO - NOTNLM
OT  - bacteriostatic
OT  - methylsulfonylmethane
OT  - microbial drug resistance
OT  - vancomycin-resistant Enterococcus faecium
EDAT- 2020/06/12 06:00
MHDA- 2021/10/07 06:00
CRDT- 2020/06/12 06:00
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/10/07 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
AID - 10.1089/mdr.2019.0454 [doi]
PST - ppublish
SO  - Microb Drug Resist. 2021 Jan;27(1):13-17. doi: 10.1089/mdr.2019.0454. Epub 2020 
      Jun 9.