PMID- 3252260
OWN - NLM
STAT- MEDLINE
DCOM- 19890808
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 31
IP  - 1
DP  - 1988 Sep
TI  - Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.
PG  - 53-7
AB  - Recent evidence indicates that when 1-(3-trifluoromethylphenyl)piperazine (TFMPP) 
      is used as a training drug in the drug discrimination paradigm it produces a 
      stimulus effect that is site-selective at the 5-HT1B receptor. The present study 
      sought to employ this procedure in order to assess the similarity of novel agents 
      to TFMPP. First, rats were trained to reliably discriminate between the stimulus 
      properties of intraperitoneally administered 1.0 mg/kg TFMPP and its vehicle. 
      Following the acquisition of this discrimination, administration of various doses 
      of TFMPP produced a typical dose-response relationship with an ED50 of 0.27 
      mg/kg. Rats were subsequently tested with another 5-HT1B specific agonist 
      1-(3-chlorophenyl)piperazine (mCPP) and a 5-HT releasing agent norfenfluramine 
      and both produced TFMPP-like discriminative responding in a dose-dependent 
      manner. In contrast, the 5-HT2 agonist 
      4-iodo-1-(2,5-dimethoxyphenyl)-2-aminopropane (DOI) did not generalize from 
      TFMPP. Other drugs, previously trained in other rats and shown to generalize to 
      TFMPP, viz., ethanol, tetrahydro-beta-carboline (THBC) and 
      3,4-methylenedioxymethamphetamine (MDMA) did not produce TFMPP-like responding. 
      These results provide further evidence for the 5-HT1B receptor acting as the site 
      for the discriminative effects of TFMPP. In addition, the transfer of 
      discrimination between TFMPP and either ethanol, THBC or MDMA appears to be 
      asymmetrical. Reasons for this one-way generalization are suggested.
FAU - Schechter, M D
AU  - Schechter MD
AD  - Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 
      Rootstown 44272.
LA  - eng
GR  - DA 04181/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Pharmaceutical Vehicles)
RN  - 0 (Piperazines)
RN  - 0 (Receptors, Serotonin)
RN  - 1886-26-6 (Norfenfluramine)
RN  - 25R3ONU51C (1-(3-trifluoromethylphenyl)piperazine)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Models, Biological
MH  - Norfenfluramine/pharmacology
MH  - Pharmaceutical Vehicles
MH  - Piperazines/*pharmacology
MH  - Rats
MH  - Receptors, Serotonin/*drug effects/physiology
MH  - Serotonin/pharmacology
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
AID - 0091-3057(88)90310-3 [pii]
AID - 10.1016/0091-3057(88)90310-3 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1988 Sep;31(1):53-7. doi: 10.1016/0091-3057(88)90310-3.