PMID- 32523034
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20220422
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 44
IP  - 9
DP  - 2020 Sep
TI  - Potential therapeutic applications of the gut microbiome in obesity: from brain 
      function to body detoxification.
PG  - 1818-1831
LID - 10.1038/s41366-020-0618-3 [doi]
AB  - The prevalence of obesity is rising every year and associated comorbidities such 
      as cardiovascular diseases are among the leading causes of death worldwide. The 
      gut microbiota has recently emerged as a potential target for therapeutic 
      applications to prevent and treat those comorbidities. In this review, we focus 
      on three conditions related to obesity in which the use of gut microbiota 
      modulators could have benefits; mood disorders, eating behaviors, and body 
      detoxification of persistent organic pollutants (POPs). On one hand, modulation 
      of gut-derived signals to the brain in a context of obesity is involved in the 
      development of neuroinflammation and can subsequently alter behaviors. An altered 
      gut microbiome could change these signals and alleviate their consequences. On 
      the other hand, obesity is associated with an increased accumulation of 
      lipophilic contaminants, such as POPs. Targeting the microbiota could help body 
      detoxication by reducing bioavailability, enhancing degradation by bioremediation 
      or their excretion through the enterohepatic circulation. Thus, a supplementation 
      of prebiotics, probiotics, or synbiotics could represent a complementary strategy 
      to current ones, such as medication and lifestyle modifications, to decrease 
      depression, alter eating behaviors, and lower body burden of pollutants 
      considering the actual obesity epidemic our society is facing.
FAU - Choi, Beatrice S-Y
AU  - Choi BS
AD  - Quebec Heart and Lung Institute, and Department of Medicine, Universite Laval, 
      Quebec, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec, QC, 
      Canada.
FAU - Daoust, Laurence
AU  - Daoust L
AD  - Quebec Heart and Lung Institute, and Department of Medicine, Universite Laval, 
      Quebec, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec, QC, 
      Canada.
FAU - Pilon, Genevieve
AU  - Pilon G
AD  - Quebec Heart and Lung Institute, and Department of Medicine, Universite Laval, 
      Quebec, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec, QC, 
      Canada.
FAU - Marette, Andre
AU  - Marette A
AUID- ORCID: 0000-0003-3950-5973
AD  - Quebec Heart and Lung Institute, and Department of Medicine, Universite Laval, 
      Quebec, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec, QC, 
      Canada.
FAU - Tremblay, Angelo
AU  - Tremblay A
AD  - Quebec Heart and Lung Institute, and Department of Medicine, Universite Laval, 
      Quebec, QC, Canada. angelo.tremblay@kin.ulaval.ca.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec, QC, 
      Canada. angelo.tremblay@kin.ulaval.ca.
AD  - Department of Kinesiology, Universite Laval, Quebec, QC, Canada. 
      angelo.tremblay@kin.ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200610
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Prebiotics)
SB  - IM
MH  - Brain/*physiology
MH  - Dietary Supplements
MH  - Gastrointestinal Microbiome/*physiology
MH  - Humans
MH  - *Obesity/microbiology/physiopathology/therapy
MH  - Prebiotics
MH  - Probiotics/therapeutic use
MH  - Synbiotics
EDAT- 2020/06/12 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/06/12 06:00
PHST- 2019/12/11 00:00 [received]
PHST- 2020/05/22 00:00 [accepted]
PHST- 2020/05/04 00:00 [revised]
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
AID - 10.1038/s41366-020-0618-3 [pii]
AID - 10.1038/s41366-020-0618-3 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2020 Sep;44(9):1818-1831. doi: 10.1038/s41366-020-0618-3. Epub 
      2020 Jun 10.