PMID- 32524521
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20220531
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 34
IP  - 2
DP  - 2021 Apr
TI  - Identical twins with idiopathic membranous nephropathy.
PG  - 597-601
LID - 10.1007/s40620-020-00770-9 [doi]
AB  - The pathogenesis of idiopathic membranous nephropathy is associated with 
      autoantibodies, most often against the phospholipase A2 receptor (PLA2R) and with 
      genetic factors, especially those involving human leukocyte antigen (HLA) genes. 
      Idiopathic membranous nephropathy is not a typical inherited Mendelian disorder. 
      Reports of idiopathic membranous nephropathy in twins are rare. Herein, we report 
      on two twin sisters diagnosed with PLA2R-associated idiopathic membranous 
      nephropathy. We identified the HLA-DRB1*0301, HLA-DRB1*1501, and HLA-DQB1*0602 
      alleles in the twin sisters, which were reported as independent risk alleles for 
      idiopathic membranous nephropathy in the Asian population. This case report 
      provides novel evidence for the role of predisposing HLA alleles in the 
      pathogenesis of idiopathic membranous nephropathy.
FAU - Tao, Tian
AU  - Tao T
AD  - Department of Nephrology, West China Hospital, Sichuan University, Guoxue ally 
      37#, Wuhou District, Chengdu City, Sichuan Province, China.
FAU - Wang, Jue
AU  - Wang J
AD  - Clinical Transfusion Research Center, Institute of Blood Transfusion, CAMS & 
      PUMC, Chengdu, Sichuan, China.
FAU - Lei, Song
AU  - Lei S
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu city, 
      Sichuan Province, China.
FAU - Hu, Zhangxue
AU  - Hu Z
AUID- ORCID: 0000-0003-1525-2983
AD  - Department of Nephrology, West China Hospital, Sichuan University, Guoxue ally 
      37#, Wuhou District, Chengdu City, Sichuan Province, China. hzxawy@scu.edu.cn.
LA  - eng
GR  - 81470916/National Natural Science Foundation of China/
GR  - 2018SZ0122/Sichuan Province Key Technology R&D Program/
PT  - Case Reports
PT  - Journal Article
DEP - 20200610
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Autoantibodies)
RN  - 0 (PLA2R1 protein, human)
RN  - 0 (Receptors, Phospholipase A2)
SB  - IM
MH  - Alleles
MH  - Autoantibodies
MH  - *Glomerulonephritis, Membranous/diagnosis/genetics
MH  - Humans
MH  - Receptors, Phospholipase A2/genetics
MH  - Twins, Monozygotic/genetics
OTO - NOTNLM
OT  - Anti-PLA2R antibody
OT  - HLA genes
OT  - Idiopathic membranous nephropathy
OT  - Twins
EDAT- 2020/06/12 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/06/12 06:00
PHST- 2020/03/30 00:00 [received]
PHST- 2020/06/03 00:00 [accepted]
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
AID - 10.1007/s40620-020-00770-9 [pii]
AID - 10.1007/s40620-020-00770-9 [doi]
PST - ppublish
SO  - J Nephrol. 2021 Apr;34(2):597-601. doi: 10.1007/s40620-020-00770-9. Epub 2020 Jun 
      10.