PMID- 32524583
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20220102
IS  - 1098-2302 (Electronic)
IS  - 0012-1630 (Print)
IS  - 0012-1630 (Linking)
VI  - 63
IP  - 1
DP  - 2021 Jan
TI  - A novel social fear conditioning procedure alters social behavior and mTOR 
      signaling in differentially housed adolescent rats.
PG  - 74-87
LID - 10.1002/dev.22001 [doi]
AB  - Vulnerabilities to fear-related disorders can be enhanced following early life 
      adversity. This study sought to determine whether post-weaning social isolation 
      (PSI), an animal model of early life adversity, alters the development of social 
      fear in an innovative model of conditioned social fear. Male and female 
      Sprague-Dawley rats underwent either social rearing (SR) or PSI for 4 weeks 
      following weaning. Rats were then assigned to groups consisting of either 
      Footshock only, Social conditioned stimulus (CS) only, or Paired footshock with a 
      social CS. Social behavior was assessed the next day. We observed a novel 
      behavioral response in PSI rats, running in circles, that was rarely observed in 
      SR rats; moreover, this behavior was augmented after Paired treatment in PSI 
      rats. Other social behaviors were altered by both PSI and Paired footshock and 
      social CS. The mammalian target of rapamycin (mTOR) pathway was assessed using 
      immunohistochemistry for phosphorylated ribosomal protein S6 (pS6) in subregions 
      of the prefrontal cortex (PFC) and amygdala. Paired treatment produced opposite 
      effects in the PFC and amygdala in males, but no differences were observed in 
      females. Conditioned social fear produced alterations in social behavior and the 
      mTOR pathway that are dependent upon rearing condition and sex.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Dawud, Lamya'a M
AU  - Dawud LM
AUID- ORCID: 0000-0003-1810-4927
AD  - Department of Integrative Biology, University of Colorado Denver, Denver, CO, 
      USA.
FAU - Loetz, Esteban C
AU  - Loetz EC
AD  - Department of Psychology, University of Colorado Denver, Denver, CO, USA.
FAU - Lloyd, Brian
AU  - Lloyd B
AD  - Department of Pharmacology, University of Colorado Anschutz Medical School, 
      Aurora, CO, USA.
FAU - Beam, Rachel
AU  - Beam R
AD  - Department of Integrative Biology, University of Colorado Denver, Denver, CO, 
      USA.
FAU - Tran, Simon
AU  - Tran S
AD  - Department of Integrative Biology, University of Colorado Denver, Denver, CO, 
      USA.
FAU - Cowie, Kim
AU  - Cowie K
AD  - Department of Neuroscience, Children's Hospital Colorado, Aurora, CO, USA.
FAU - Browne, Kim
AU  - Browne K
AD  - Department of Inflammation and Immunity, Cleveland Clinic Lerner Research 
      Institute, Cleveland, OH, USA.
FAU - Khan, Tassawwar
AU  - Khan T
AD  - Department of Integrative Biology, University of Colorado Denver, Denver, CO, 
      USA.
FAU - Montoya, Richard
AU  - Montoya R
AD  - Department of Psychology, University of Colorado Denver, Denver, CO, USA.
FAU - Greenwood, Benjamin N
AU  - Greenwood BN
AD  - Department of Psychology, University of Colorado Denver, Denver, CO, USA.
FAU - Bland, Sondra T
AU  - Bland ST
AUID- ORCID: 0000-0002-5790-089X
AD  - Department of Psychology, University of Colorado Denver, Denver, CO, USA.
LA  - eng
GR  - R15 MH102717/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200610
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - *Conditioning, Classical
MH  - *Fear
MH  - Female
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Social Behavior
MH  - TOR Serine-Threonine Kinases
PMC - PMC7726006
MID - NIHMS1614304
OTO - NOTNLM
OT  - animal
OT  - escape reaction
OT  - models
OT  - post-traumatic
OT  - prefrontal cortex
OT  - ribosomal protein S6
OT  - social behavior
OT  - social isolation
OT  - stress disorders
COIS- Conflict of Interest. The authors have no conflict of interests to report.
EDAT- 2020/06/12 06:00
MHDA- 2021/12/15 06:00
PMCR- 2022/01/01
CRDT- 2020/06/12 06:00
PHST- 2019/11/12 00:00 [received]
PHST- 2020/04/07 00:00 [revised]
PHST- 2020/04/30 00:00 [accepted]
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.1002/dev.22001 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2021 Jan;63(1):74-87. doi: 10.1002/dev.22001. Epub 2020 Jun 10.