PMID- 32524651
OWN - NLM
STAT- MEDLINE
DCOM- 20211006
LR  - 20211006
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 48
IP  - 2
DP  - 2021 Feb
TI  - Acral fibromyxoma with loss of Rb1 by immunohistochemistry and fluorescence in 
      situ hybridization: A diagnostically exploitable marker.
PG  - 295-301
LID - 10.1111/cup.13773 [doi]
AB  - Acral fibromyxoma (AF) is a slow growing benign soft tissue tumor with 
      predilection to subungal and periungal region of the hands or feet. CD34 is 
      consistently expressed whereas very recently loss of Rb1 expression was described 
      as a possible driver molecular event for this entity. Herein we present two 
      additional cases of AF with loss of Rb1 expression by IHC and subsequent 
      confirmation of loss of the RB1 gene locus by fluorescence in situ hybridization 
      (FISH). We hope to raise awareness in dermatopathology community of this new 
      discovery, which can be diagnostically exploitable for this distinct and probably 
      underreported neoplasm.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Motanagh, Samaneh
AU  - Motanagh S
AD  - Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical 
      Center, Lebanon, New Hampshire, USA.
FAU - Bridge, Julia A
AU  - Bridge JA
AD  - Division of Molecular Pathology, The Translational Genomics Research Institute 
      (TGen), Phoenix, Arizona, USA.
AD  - Department of Pathology and Microbiology, University of Nebraska Medical Center, 
      Omaha, Nebraska, USA.
FAU - Linos, Konstantinos
AU  - Linos K
AUID- ORCID: 0000-0001-9462-652X
AD  - Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical 
      Center, Lebanon, New Hampshire, USA.
AD  - Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
LA  - eng
PT  - Case Reports
DEP - 20200706
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RB1 protein, human)
RN  - 0 (Retinoblastoma Binding Proteins)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - *Biomarkers, Tumor/genetics/metabolism
MH  - *Fibroma/diagnosis/genetics/metabolism/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Retinoblastoma Binding Proteins/*deficiency/metabolism
MH  - *Skin Neoplasms/diagnosis/genetics/metabolism/pathology
MH  - Ubiquitin-Protein Ligases/*deficiency/metabolism
OTO - NOTNLM
OT  - FISH
OT  - RB1
OT  - acral fibromyxoma
EDAT- 2020/06/12 06:00
MHDA- 2021/10/07 06:00
CRDT- 2020/06/12 06:00
PHST- 2020/04/17 00:00 [received]
PHST- 2020/05/23 00:00 [revised]
PHST- 2020/06/04 00:00 [accepted]
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/10/07 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
AID - 10.1111/cup.13773 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2021 Feb;48(2):295-301. doi: 10.1111/cup.13773. Epub 2020 Jul 6.