PMID- 32525266
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 52
IP  - 6
DP  - 2020 Dec
TI  - Radiomic Analysis of Native T(1) Mapping Images Discriminates Between MYH7 and 
      MYBPC3-Related Hypertrophic Cardiomyopathy.
PG  - 1714-1721
LID - 10.1002/jmri.27209 [doi]
AB  - BACKGROUND: The phenotype via conventional cardiac MRI analysis of MYH7 (beta-myosin 
      heavy chain)- and MYBPC3 (beta-myosin-binding protein C)-associated hypertrophic 
      cardiomyopathy (HCM) groups is similar. Few studies exist on the 
      genotypic-phenotypic association as assessed by machine learning in HCM patients. 
      PURPOSE: To explore the phenotypic differences based on radiomics analysis of 
      T(1) mapping images between MYH7 and MYBPC3-associated HCM subgroups. STUDY TYPE: 
      Prospective observational study. SUBJECTS: In all, 102 HCM patients with 
      pathogenic, or likely pathogenic mutation, in MYH7 (n = 68) or MYBPC3 (n = 34) 
      genes. FIELD STRENGTH/SEQUENCE: Cardiac MRI was performed at 3.0T with balanced 
      steady-state free precession (bSSFP), phase-sensitive inversion recovery (PSIR) 
      late gadolinium enhancement (LGE), and modified Look-Locker inversion recovery 
      (MOLLI) T(1) mapping sequences. ASSESSMENT: All patients underwent 
      next-generation sequencing and Sanger genetic sequencing. Left ventricular native 
      T(1) and LGE were analyzed. One hundred and fifty-seven radiomic features were 
      extracted and modeled using a support vector machine (SVM) combined with 
      principal component analysis (PCA). Each subgroup was randomly split 4:1 (feature 
      selection / test validation). STATISTICAL TESTS: Mann-Whitney U-tests and 
      Student's t-tests were performed to assess differences between subgroups. A 
      receiver operating characteristic (ROC) curve was used to assess the model's 
      ability to stratify patients based on radiomic features. RESULTS: There were no 
      significant differences between MYH7- and MYBPC3-associated HCM subgroups based 
      on traditional native T(1) values (global, basal, and middle short-axis slice 
      native T(1) ; P = 0.760, 0.914, and 0.178, respectively). However, the SVM model 
      combined with PCA achieved an accuracy and area under the curve (AUC) of 92.0% 
      and 0.968 (95% confidence interval [CI]: 0.968-0.971), respectively. For the test 
      validation dataset, the accuracy and AUC were 85.5% and 0.886 (95% CI: 
      0.881-0.901), respectively. DATA CONCLUSION: Radiomic analysis of native T(1) 
      mapping images may be able to discriminate between MYH7- and MYBPC3-associated 
      HCM patients, exceeding the performance of conventional native T(1) values. LEVEL 
      OF EVIDENCE: 3 TECHNICAL EFFICACY STAGE: 2 J. MAGN. RESON. IMAGING 
      2020;52:1714-1721.
CI  - (c) 2020 International Society for Magnetic Resonance in Medicine.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
AD  - College of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, 
      University of Birmingham, Birmingham, UK.
FAU - Yang, Fuyao
AU  - Yang F
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Liu, Wentao
AU  - Liu W
AD  - Medical Big Data Center, West China Hospital, Sichuan University, Chengdu, P. R. 
      China.
FAU - Sun, Jiayu
AU  - Sun J
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, P. R. 
      China.
FAU - Han, Yuchi
AU  - Han Y
AD  - Department of Medicine (Cardiovascular Division), University of Pennsylvania, 
      Philadelphia, Pennsylvania, USA.
FAU - Li, Dong
AU  - Li D
AD  - Division of Hospital Medicine, Emory University School of Medicine, Atlanta, 
      Georgia, USA.
FAU - Gkoutos, Georgios V
AU  - Gkoutos GV
AD  - College of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, 
      University of Birmingham, Birmingham, UK.
AD  - MRC Health Data Research UK (HDR UK), London, UK.
FAU - Zhu, Yanjie
AU  - Zhu Y
AD  - Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of 
      Advanced Technology, Chinese Academy of Sciences, Shenzhen, P. R. China.
FAU - Chen, Yucheng
AU  - Chen Y
AUID- ORCID: 0000-0002-0601-8039
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, P. R. 
      China.
AD  - Center of Rare diseases, West China Hospital, Sichuan University, Chengdu, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200611
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (MYH7 protein, human)
RN  - AU0V1LM3JT (Gadolinium)
RN  - EC 3.6.1.- (Cardiac Myosins)
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
MH  - Cardiac Myosins/genetics
MH  - *Cardiomyopathy, Hypertrophic/diagnostic imaging/genetics
MH  - Contrast Media
MH  - *Gadolinium
MH  - Heart Ventricles
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Myosin Heavy Chains/genetics
OTO - NOTNLM
OT  - cardiomyopathy, hypertrophic
OT  - human genetics
OT  - machine learning
OT  - magnetic resonance imaging
OT  - support vector machine
EDAT- 2020/06/12 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/06/12 06:00
PHST- 2020/02/26 00:00 [received]
PHST- 2020/05/08 00:00 [revised]
PHST- 2020/05/12 00:00 [accepted]
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
AID - 10.1002/jmri.27209 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2020 Dec;52(6):1714-1721. doi: 10.1002/jmri.27209. Epub 
      2020 Jun 11.