PMID- 32526539
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20210322
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 135
DP  - 2020 Aug
TI  - The role of immune and oxidative pathways in menstrual cycle associated 
      depressive, physio-somatic, breast and anxiety symptoms: Modulation by sex 
      hormones.
PG  - 110158
LID - S0022-3999(20)30169-0 [pii]
LID - 10.1016/j.jpsychores.2020.110158 [doi]
AB  - OBJECTIVE: To examine whether 1) immune and nitro-oxidative stress (IO&NS) 
      biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in 
      IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms 
      and plasma estradiol and progesterone. METHODS: This longitudinal study examined 
      41 women who completed the Daily Record of Severity of Problems (DRSP) rating 
      scale during 28 consecutive days and assayed plasma levels of complement C3 and 
      C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced 
      oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide 
      metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), 
      sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 
      (D14), 21 (D21) and 28 (D28) of the MC. MC Associated Syndrome (MCAS) was 
      diagnosed when the summed DRSP score during the MC is >0.666 percentile. RESULTS: 
      All biomarkers, except hsCRP, showed significant alterations during the MC. 
      Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at 
      D21 in MCAS. Total DRSP scores were predicted by the combined effects of C4 
      (positively) and AREase and malondialdehyde (MDA) (both inversely associated). 
      Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of 
      Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and 
      AREase activities and levels of -SH groups. CONCLUSION: PMS/MCAS is not 
      accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant 
      defenses and increased C4 may play a role in MC symptoms while sex hormones may 
      have a protective effect against oxidative stress toxicity.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Roomruangwong, Chutima
AU  - Roomruangwong C
AD  - Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Matsumoto, Andressa Keiko
AU  - Matsumoto AK
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Michelin, Ana Paula
AU  - Michelin AP
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - de Oliveira Semeao, Laura
AU  - de Oliveira Semeao L
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - de Lima Pedrao, Joao Victor
AU  - de Lima Pedrao JV
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Moreira, Estefania G
AU  - Moreira EG
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Sirivichayakul, Sunee
AU  - Sirivichayakul S
AD  - Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand. Electronic address: Sunee.S@chula.ac.th.
FAU - Carvalho, Andre
AU  - Carvalho A
AD  - Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for 
      Addiction and Mental Health (CAMH), Toronto, ON, Canada. Electronic address: 
      andre.carvalho@camh.ca.
FAU - Barbosa, Decio S
AU  - Barbosa DS
AD  - Health Sciences Graduate Program, Health Sciences Center, State University of 
      Londrina, Londrina, PR, Brazil.
FAU - Maes, Michael
AU  - Maes M
AD  - Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, 
      Bulgaria; IMPACT Strategic Research Center, Deakin University, Geelong, 
      Australia. Electronic address: dr.michaelmaes@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200523
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
RN  - 0 (Biomarkers)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Anxiety/complications/*metabolism/physiopathology
MH  - Biomarkers/blood
MH  - Breast/*pathology
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - Gonadal Steroid Hormones/*metabolism
MH  - Humans
MH  - Longitudinal Studies
MH  - Menstrual Cycle/*metabolism/physiology/psychology
MH  - Middle Aged
MH  - Nitric Oxide/blood
MH  - *Oxidative Stress
OTO - NOTNLM
OT  - Antioxidants
OT  - Anxiety
OT  - Biomarkers
OT  - Depression
OT  - Inflammation
OT  - Neuro-immune
OT  - Oxidative stress
OT  - Premenstrual syndrome
COIS- Declaration of Competing Interest The authors have no conflict of interest with 
      any commercial or other association in connection with the submitted article.
EDAT- 2020/06/12 06:00
MHDA- 2021/03/23 06:00
CRDT- 2020/06/12 06:00
PHST- 2020/02/24 00:00 [received]
PHST- 2020/04/16 00:00 [revised]
PHST- 2020/05/19 00:00 [accepted]
PHST- 2020/06/12 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/06/12 06:00 [entrez]
AID - S0022-3999(20)30169-0 [pii]
AID - 10.1016/j.jpsychores.2020.110158 [doi]
PST - ppublish
SO  - J Psychosom Res. 2020 Aug;135:110158. doi: 10.1016/j.jpsychores.2020.110158. Epub 
      2020 May 23.