PMID- 32526978
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 6
DP  - 2020 Jun 9
TI  - Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left 
      Ventricular Function: A Real-Life Propensity-Score Matched Study.
LID - 10.3390/jcm9061792 [doi]
LID - 1792
AB  - BACKGROUND: Transcatheter mitral valve repair (TMVR) could improve survival in 
      functional mitral regurgitation (FMR), but it is necessary to consider the 
      influence of left ventricular ejection fraction (LVEF). Therefore, we compare the 
      outcomes after TMVR with Mitraclip((R)) between two groups according to LVEF. 
      METHODS: In an observational registry study, we compared the outcomes in patients 
      with FMR who underwent TMVR with and without LVEF <30%. The primary endpoint was 
      the combined one-year all-cause mortality and unplanned hospital readmissions due 
      to HF. The secondary end-points were New York Heart Association (NYHA) functional 
      class and mitral regurgitation (MR) severity. Propensity-score matching was used 
      to create two groups with the same baseline characteristics, except for baseline 
      LVEF. RESULTS: Among 535 FMR eligible patients, 144 patients with LVEF <30% 
      (group 1) and 144 with LVEF >30% (group 2) had similar propensity scores and were 
      included in the analyses. The primary study endpoint was significantlly higher in 
      group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in 
      secondary endpoints without significant differences among groups. CONCLUSION: FMR 
      patients with LVEF <30% treated with MitraClip((R)) had higher mortality and 
      readmissions than patients with LVEF >/=30% treated with the same device. However, 
      both groups improved the NYHA functional class and MR severity.
FAU - Pascual, Isaac
AU  - Pascual I
AUID- ORCID: 0000-0001-5433-1364
AD  - Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto 
      Investigacion Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain.
FAU - Carrasco-Chinchilla, Fernando
AU  - Carrasco-Chinchilla F
AD  - Cardiology Department, Virgen de la Victoria University Hospital, Instituto de 
      Investigacion Biomedica de Malaga (IBIMA), University of Malaga, CIBERCV, 29010 
      Malaga, Spain.
FAU - Benito-Gonzalez, Tomas
AU  - Benito-Gonzalez T
AUID- ORCID: 0000-0002-8428-9248
AD  - Cardiology Department. University Hospital of Leon, 24008 Leon, Spain.
FAU - Li, Chi Hion
AU  - Li CH
AUID- ORCID: 0000-0001-7556-3711
AD  - Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain.
FAU - Avanzas, Pablo
AU  - Avanzas P
AUID- ORCID: 0000-0002-4958-6108
AD  - Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto 
      Investigacion Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain.
FAU - Nombela-Franco, Luis
AU  - Nombela-Franco L
AD  - Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC, 28040 Madrid, 
      Spain.
FAU - Pan, Manuel
AU  - Pan M
AD  - Cardiology Department, Reina Sofia University Hospital, University of Cordoba 
      (IMIBIC), 14004 Cordoba, Spain.
FAU - Serrador Frutos, Ana
AU  - Serrador Frutos A
AD  - CIBERCV, Cardiology Department, Hospital Clinico Universitario de Valladolid, 
      47003 Valladolid, Spain.
FAU - Freixa, Xavier
AU  - Freixa X
AD  - Cardiology Department, Institut Clinic Cardiovascular, Hospital Clinic de 
      Barcelona, 08036 Barcelona, Spain.
FAU - Trillo-Nouche, Ramiro
AU  - Trillo-Nouche R
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, CIBERCV, 15706 Santiago de Compostela, Spain.
FAU - Hernandez-Antolin, Rosa A
AU  - Hernandez-Antolin RA
AD  - Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain.
FAU - Andraka Ikazuriaga, Leire
AU  - Andraka Ikazuriaga L
AD  - Cardiology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain.
FAU - Cruz-Gonzalez, Ignacio
AU  - Cruz-Gonzalez I
AD  - Cardiology Department, University Hospital of Salamanca, IBSAL, Institute of 
      Biomedical Research of Salamanca, University of Salamanca, CIBERCV, 37007 
      Salamanca, Spain.
FAU - Lopez-Minguez, Jose R
AU  - Lopez-Minguez JR
AUID- ORCID: 0000-0002-0657-4457
AD  - Cardiology Department, University Hospital of Badajoz, 06080 Badajoz, Spain.
FAU - Diez, Jose L
AU  - Diez JL
AUID- ORCID: 0000-0001-9921-8023
AD  - Cardiology Department, Hospital Universitario y Politecnico La Fe, 46026 
      Valencia, Spain.
FAU - Berenguer-Jofresa, Alberto
AU  - Berenguer-Jofresa A
AD  - Cardiology Department, Hospital General Universitario de Valencia, 46014 
      Valencia, Spain.
FAU - Sanchis, Juan
AU  - Sanchis J
AD  - Cardiology Department, University Clinic Hospital of Valencia, University of 
      Valencia, INCLIVA, CIBERCV, 46010 Valencia, Spain.
FAU - Ruiz-Quevedo, Valeriano
AU  - Ruiz-Quevedo V
AD  - Cardiology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain.
FAU - Urbano-Carrillo, Cristobal
AU  - Urbano-Carrillo C
AD  - Cardiology Department., Complejo Hospital Regional Universitario de Malaga, 29010 
      Malaga, Spain.
FAU - Dominguez, Juan F Oteo
AU  - Dominguez JFO
AD  - Cardiology Department, University Hospital Puerta de Hierro/Majadahonda, 28222 
      Madrid, Spain.
FAU - Ortas-Nadal, Maria R
AU  - Ortas-Nadal MR
AD  - Cardiology Department, University Hospital Miguel Servet, 50009 Zaragoza, Spain.
FAU - Molina Navarro, Eduardo
AU  - Molina Navarro E
AD  - Cardiology Department, University Hospital Virgen de las Nieves, 18014 Granada, 
      Spain.
FAU - Carrillo, Xavier
AU  - Carrillo X
AD  - Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 
      Barcelona, Spain.
FAU - Alonso-Briales, Juan H
AU  - Alonso-Briales JH
AD  - Cardiology Department, Virgen de la Victoria University Hospital, Instituto de 
      Investigacion Biomedica de Malaga (IBIMA), University of Malaga, CIBERCV, 29010 
      Malaga, Spain.
FAU - Fernandez-Vazquez, Felipe
AU  - Fernandez-Vazquez F
AUID- ORCID: 0000-0001-7187-1290
AD  - Cardiology Department. University Hospital of Leon, 24008 Leon, Spain.
FAU - Asmarats Serra, Luis
AU  - Asmarats Serra L
AD  - Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain.
FAU - Hernandez-Vaquero, Daniel
AU  - Hernandez-Vaquero D
AUID- ORCID: 0000-0003-3518-6629
AD  - Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto 
      Investigacion Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain.
FAU - Jimenez-Quevedo, Pilar
AU  - Jimenez-Quevedo P
AD  - Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC, 28040 Madrid, 
      Spain.
FAU - Mesa, Dolores
AU  - Mesa D
AD  - Cardiology Department, Reina Sofia University Hospital, University of Cordoba 
      (IMIBIC), 14004 Cordoba, Spain.
FAU - Rodriguez-Gabella, Tania
AU  - Rodriguez-Gabella T
AD  - CIBERCV, Cardiology Department, Hospital Clinico Universitario de Valladolid, 
      47003 Valladolid, Spain.
FAU - Regueiro, Ander
AU  - Regueiro A
AD  - Cardiology Department, Institut Clinic Cardiovascular, Hospital Clinic de 
      Barcelona, 08036 Barcelona, Spain.
FAU - Martinez Monzonis, Amparo
AU  - Martinez Monzonis A
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, CIBERCV, 15706 Santiago de Compostela, Spain.
FAU - Salido Tahoces, Luisa
AU  - Salido Tahoces L
AD  - Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain.
FAU - Ruiz Gomez, Lara
AU  - Ruiz Gomez L
AD  - Cardiology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain.
FAU - Trejo-Velasco, Blanca
AU  - Trejo-Velasco B
AUID- ORCID: 0000-0001-8163-5064
AD  - Cardiology Department, University Hospital of Salamanca, IBSAL, Institute of 
      Biomedical Research of Salamanca, University of Salamanca, CIBERCV, 37007 
      Salamanca, Spain.
FAU - Becerra-Munoz, Victor M
AU  - Becerra-Munoz VM
AD  - Cardiology Department, Virgen de la Victoria University Hospital, Instituto de 
      Investigacion Biomedica de Malaga (IBIMA), University of Malaga, CIBERCV, 29010 
      Malaga, Spain.
FAU - Garrote-Coloma, Carmen
AU  - Garrote-Coloma C
AD  - Cardiology Department. University Hospital of Leon, 24008 Leon, Spain.
FAU - Fernandez Peregrina, Estafania
AU  - Fernandez Peregrina E
AUID- ORCID: 0000-0002-3025-8251
AD  - Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain.
FAU - Lorca, Rebeca
AU  - Lorca R
AD  - Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto 
      Investigacion Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain.
FAU - Agustin, Jose A De
AU  - Agustin JA
AD  - Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC, 28040 Madrid, 
      Spain.
FAU - Romero, Miguel
AU  - Romero M
AD  - Cardiology Department, Reina Sofia University Hospital, University of Cordoba 
      (IMIBIC), 14004 Cordoba, Spain.
FAU - Amat-Santos, Ignacio J
AU  - Amat-Santos IJ
AD  - CIBERCV, Cardiology Department, Hospital Clinico Universitario de Valladolid, 
      47003 Valladolid, Spain.
FAU - Sabate, Manel
AU  - Sabate M
AUID- ORCID: 0000-0002-2316-3705
AD  - Cardiology Department, Institut Clinic Cardiovascular, Hospital Clinic de 
      Barcelona, 08036 Barcelona, Spain.
FAU - Alvarez, Ana B Cid
AU  - Alvarez ABC
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, CIBERCV, 15706 Santiago de Compostela, Spain.
FAU - Hernandez-Garcia, Jose M
AU  - Hernandez-Garcia JM
AD  - Cardiology Department, Virgen de la Victoria University Hospital, Instituto de 
      Investigacion Biomedica de Malaga (IBIMA), University of Malaga, CIBERCV, 29010 
      Malaga, Spain.
FAU - Gualis, Javier
AU  - Gualis J
AD  - Cardiology Department. University Hospital of Leon, 24008 Leon, Spain.
FAU - Arzamendi, Dabit
AU  - Arzamendi D
AD  - Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain.
FAU - Moris, Cesar
AU  - Moris C
AUID- ORCID: 0000-0002-2871-190X
AD  - Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto 
      Investigacion Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain.
FAU - Tirado-Conte, Gabriela
AU  - Tirado-Conte G
AD  - Cardiovascular Institute, Hospital Clinico San Carlos, IdISSC, 28040 Madrid, 
      Spain.
FAU - Sanchez-Recalde, Angel
AU  - Sanchez-Recalde A
AD  - Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain.
FAU - Estevez-Loureiro, Rodrigo
AU  - Estevez-Loureiro R
AD  - Cardiology Department, Alvaro Cunqueiro University Hospital, 36213 Vigo, Spain.
LA  - eng
PT  - Journal Article
DEP - 20200609
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7356666
OTO - NOTNLM
OT  - Mitraclip
OT  - functional mitral regurgitation
OT  - left ventricular ejection Fraction
OT  - transcatheter
COIS- The authors declare no conflicts of interest.
EDAT- 2020/06/13 06:00
MHDA- 2020/06/13 06:01
PMCR- 2020/06/09
CRDT- 2020/06/13 06:00
PHST- 2020/04/28 00:00 [received]
PHST- 2020/05/24 00:00 [revised]
PHST- 2020/06/01 00:00 [accepted]
PHST- 2020/06/13 06:00 [entrez]
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2020/06/13 06:01 [medline]
PHST- 2020/06/09 00:00 [pmc-release]
AID - jcm9061792 [pii]
AID - jcm-09-01792 [pii]
AID - 10.3390/jcm9061792 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jun 9;9(6):1792. doi: 10.3390/jcm9061792.