PMID- 32528319
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in 
      Severe Mental Disorder.
PG  - 391
LID - 10.3389/fpsyt.2020.00391 [doi]
LID - 391
AB  - OBJECTIVE: Individuals exposed to childhood trauma display longstanding 
      modifications of the Hypothalamic-Pituitary-Adrenal (HPA) axis, as well as 
      cognitive impairments. Schizophrenia spectrum disorder (SZ) and bipolar disorders 
      (BD) are characterised by higher prevalence of childhood trauma, abnormal HPA 
      axis, and cognitive dysfunction. Elevated cortisol metabolism was recently 
      demonstrated in both disorders. However, it is yet to be established if childhood 
      adversity is associated with cortisol metabolism in this population, and how this 
      may be associated with cognitive function. METHODS: One-hundred-and-fourteen 
      participants with a DSM-IV SZ or BD diagnosis took part in the study. Diagnoses 
      were evaluated by the Structured Clinical Interview for DSM-IV Axis I disorders 
      (SCID-I). Estimated cortisol metabolizing activity (5alpha-reductase and 
      5beta-reductase) was assessed by urinary free cortisol, and metabolites. All 
      patients underwent cognitive assessment and completed the Childhood Trauma 
      Questionnaire. RESULTS: Estimated 5beta-reductase activity was elevated in 
      participant with childhood physical abuse (r = 0.26, p = 0.005). After adjusting 
      for age, sex and diagnosis, physical abuse was still nominally associated with 
      elevated 5beta-reductase. Moreover, only high 5alpha-reductase activity was negatively 
      correlated with working memory and executive performance (r = -0.23, p = 0.01; r 
      = -0.19, p = 0.05, respectively), however this disappeared after adjusting for 
      age, sex and diagnosis. Cortisol metabolism did not mediate the association 
      between childhood trauma and cognitive function. CONCLUSIONS: Our study indicates 
      that childhood physical abuse is associated with elevated cortisol metabolism 
      (5beta-reductase) in adults with a SZ or BD disorder. However, our study did not 
      support cortisol metabolism as a mediator between childhood trauma experiences 
      and cognitive function within these disorders.
CI  - Copyright (c) 2020 Aas, Ueland, Inova, Melle, Andreassen and Steen.
FAU - Aas, Monica
AU  - Aas M
AD  - NORMENT, Psychosis Research Unit, Division of Mental Health and Addiction, Oslo 
      University Hospital, Oslo, Norway.
FAU - Ueland, Torill
AU  - Ueland T
AD  - NORMENT, Psychosis Research Unit, Division of Mental Health and Addiction, Oslo 
      University Hospital, Oslo, Norway.
AD  - Department of Psychology, University of Oslo, Oslo, Norway.
FAU - Inova, Amina
AU  - Inova A
AD  - NORMENT, Psychosis Research Unit, Division of Mental Health and Addiction, Oslo 
      University Hospital, Oslo, Norway.
FAU - Melle, Ingrid
AU  - Melle I
AD  - NORMENT, Psychosis Research Unit, Division of Mental Health and Addiction, Oslo 
      University Hospital, Oslo, Norway.
FAU - Andreassen, Ole A
AU  - Andreassen OA
AD  - NORMENT, Psychosis Research Unit, Division of Mental Health and Addiction, Oslo 
      University Hospital, Oslo, Norway.
AD  - NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
FAU - Steen, Nils Eiel
AU  - Steen NE
AD  - NORMENT, Psychosis Research Unit, Division of Mental Health and Addiction, Oslo 
      University Hospital, Oslo, Norway.
AD  - NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20200514
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7247816
OTO - NOTNLM
OT  - bipolar disorders
OT  - childhood trauma and adversity
OT  - clinical features
OT  - cognitive function
OT  - cortisol metabolism
OT  - schizophrenia
EDAT- 2020/06/13 06:00
MHDA- 2020/06/13 06:01
PMCR- 2020/05/14
CRDT- 2020/06/13 06:00
PHST- 2019/11/18 00:00 [received]
PHST- 2020/04/17 00:00 [accepted]
PHST- 2020/06/13 06:00 [entrez]
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2020/06/13 06:01 [medline]
PHST- 2020/05/14 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.00391 [doi]
PST - epublish
SO  - Front Psychiatry. 2020 May 14;11:391. doi: 10.3389/fpsyt.2020.00391. eCollection 
      2020.