PMID- 32528945
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 8
DP  - 2020
TI  - Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue 
      Hypoxia.
PG  - 511
LID - 10.3389/fbioe.2020.00511 [doi]
LID - 511
AB  - Oxygen deficiency resulting from bone fracture-induced vascular disruption leads 
      to massive cell death and delayed osteoblast differentiation, ultimately 
      impairing new bone formation and fracture healing. Enhancing local tissue 
      oxygenation can help promote bone regeneration. In this work, an injectable 
      composite oxygen-generating system consisting of calcium peroxide 
      (CaO(2))/manganese dioxide (MnO(2))-encapsulated poly lactic-co-glycolic acid 
      (PLGA) microparticles (CaO(2) + MnO(2)@PLGA MPs) is proposed for the local 
      delivery of oxygen. By utilizing a series of methodologies, the impacts of each 
      component used for MP fabrication on the oxygen release behavior and cytotoxicity 
      of the CaO(2) + MnO(2)@ PLGA MPs are thoroughly investigated. Our analytical data 
      obtained from in vitro studies indicate that the optimized CaO(2) + MnO(2)@PLGA 
      MPs developed in this study can effectively relieve the hypoxia of preosteoblast 
      MC3T3-E1 cells that are grown under low oxygen tension and promote their 
      osteogenic differentiation, thus holding great promise in enhancing fractural 
      healing by increasing tissue oxygenation.
CI  - Copyright (c) 2020 Hsieh, Lin, Chen, Chen, Lai and Huang.
FAU - Hsieh, Tai-En
AU  - Hsieh TE
AD  - Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 
      Taiwan.
FAU - Lin, Sheng-Ju
AU  - Lin SJ
AD  - Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 
      Taiwan.
FAU - Chen, Li-Chi
AU  - Chen LC
AD  - Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 
      Taiwan.
AD  - Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
FAU - Chen, Chun-Chieh
AU  - Chen CC
AD  - Department of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 
      City, Taiwan.
AD  - Bone and Joint Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 
      City, Taiwan.
FAU - Lai, Po-Liang
AU  - Lai PL
AD  - Department of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 
      City, Taiwan.
AD  - Bone and Joint Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan 
      City, Taiwan.
FAU - Huang, Chieh-Cheng
AU  - Huang CC
AD  - Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200526
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC7264163
OTO - NOTNLM
OT  - PLGA microparticles
OT  - hypoxia
OT  - hypoxia-inducible factor
OT  - oxygen-generating biomaterials
OT  - peroxide
EDAT- 2020/06/13 06:00
MHDA- 2020/06/13 06:01
PMCR- 2020/01/01
CRDT- 2020/06/13 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/04/30 00:00 [accepted]
PHST- 2020/06/13 06:00 [entrez]
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2020/06/13 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fbioe.2020.00511 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2020 May 26;8:511. doi: 10.3389/fbioe.2020.00511. 
      eCollection 2020.