PMID- 32530569
OWN - NLM
STAT- MEDLINE
DCOM- 20210609
LR  - 20210609
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 22
IP  - 11
DP  - 2020 Nov
TI  - (18) F-FDG PET/CT brain glucose metabolism as a marker of different types of 
      depression comorbidity in chronic heart failure patients with impaired systolic 
      function.
PG  - 2138-2146
LID - 10.1002/ejhf.1866 [doi]
AB  - AIMS: Depression is an important issue in heart failure (HF). The study 
      investigated whole-brain and regional brain glucose metabolism in HF patients and 
      its association with depression comorbidity. METHODS AND RESULTS: Twenty-nine 
      hospitalized patients with symptomatic systolic HF (left ventricular ejection 
      fraction <40%), New York Heart Association (NYHA) class II-IV and mean age of 
      55.5 +/- 12.0 years, had psychometric questionnaires before discharge and an (18) 
      F-FDG PET/CT brain scan after discharge. Semi-automated image analysis was 
      performed on all cases and 30 matched controls. The metabolic parameter mean 
      standardized uptake value (SUV(mean) ) was calculated for the whole brain and 
      three brain regions implicated in depression pathogenesis. A standardized 
      SUV(mean) was also estimated by dividing regional brain SUV(mean) with 
      whole-brain SUV(mean) . Cases had lower average whole-brain SUV(mean) 
      (3.90 +/- 1.49 vs. 5.10 +/- 1.35, P = 0.001) and average regional brain SUV(mean) 
      (4.57 +/- 2.31 vs. 9.96 +/- 3.58, P < 0.001) compared to controls. Whole-brain 
      SUV(mean) had a significant correlation with patient age, NYHA class, diabetes, 
      creatinine levels, depression, and cognitive impairment. Regional brain SUV(mean) 
      was correlated with whole-brain SUV(mean) and depression. The standardized 
      SUV(mean) , in particular, was found to be a robust index that could 
      differentiate HF patients with 'epiphenomenal' (>0.93) or 'real' (</=0.93) 
      depression. CONCLUSION: Heart failure patients with more severe disease showed 
      whole-brain and regional brain hypometabolism in (18) F-FDG PET/CT. Depressed HF 
      patients (Beck Depression Inventory score >13) exhibited different metabolic 
      patterns that could be used to differentiate between 'epiphenomenal' and 'real' 
      depression. Namely, presence of whole-brain hypometabolism suggested 
      'epiphenomenal' depression, whereas absence suggested 'real' depression. Presence 
      of significant relative regional brain hypometabolism enhanced the likelihood of 
      'real' depression diagnosis.
CI  - (c) 2020 European Society of Cardiology.
FAU - Lyra, Vassiliki
AU  - Lyra V
AD  - 2nd Department of Radiology, Nuclear Medicine Section, Attikon University 
      Hospital, Athens, Greece.
FAU - Parissis, John
AU  - Parissis J
AD  - 2nd Department of Cardiology, Attikon University Hospital, Athens, Greece.
FAU - Kallergi, Maria
AU  - Kallergi M
AD  - Department of Biomedical Engineering, University of West Attica, UNIWA & 
      Biomedical Research Foundation of the Academy of Athens, BRFAA, Athens, Greece.
FAU - Rizos, Emmanouil
AU  - Rizos E
AD  - 2nd Department of Psychiatry, Attikon University Hospital, Athens, Greece.
FAU - Filippatos, Gerasimos
AU  - Filippatos G
AD  - 2nd Department of Cardiology, Attikon University Hospital, Athens, Greece.
FAU - Kremastinos, Dimitrios
AU  - Kremastinos D
AD  - Department of Cardiology, National and Kapodistrian University of Athens, Athens, 
      Greece.
FAU - Chatziioannou, Sofia
AU  - Chatziioannou S
AD  - 2nd Department of Radiology, Nuclear Medicine Section, Attikon University 
      Hospital, Athens, Greece.
AD  - Department of Nuclear Medicine, Biomedical Research Foundation of the Academy of 
      Athens, BRFAA, Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20200612
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Brain/diagnostic imaging/metabolism
MH  - Comorbidity
MH  - *Depression/diagnostic imaging/metabolism
MH  - *Fluorodeoxyglucose F18
MH  - *Glucose/metabolism
MH  - *Heart Failure/diagnostic imaging/metabolism/psychology
MH  - Humans
MH  - Middle Aged
MH  - Positron Emission Tomography Computed Tomography
MH  - Positron-Emission Tomography
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - 18F-FDG PET/CT
OT  - Beck Depression Inventory
OT  - Brain glucose metabolism
OT  - Depression
OT  - Heart failure
EDAT- 2020/06/13 06:00
MHDA- 2021/06/10 06:00
CRDT- 2020/06/13 06:00
PHST- 2019/12/04 00:00 [received]
PHST- 2020/04/16 00:00 [revised]
PHST- 2020/05/05 00:00 [accepted]
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2021/06/10 06:00 [medline]
PHST- 2020/06/13 06:00 [entrez]
AID - 10.1002/ejhf.1866 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2020 Nov;22(11):2138-2146. doi: 10.1002/ejhf.1866. Epub 2020 
      Jun 12.