PMID- 32530864
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20230927
IS  - 1536-7355 (Electronic)
IS  - 1076-1608 (Linking)
VI  - 27
IP  - 8
DP  - 2021 Dec 1
TI  - Prevalence of Osteopenia in Drug-Naive Patients With Antineutrophil Cytoplasmic 
      Antibody-Associated Vasculitis: A Monocentric Study.
PG  - e330-e335
LID - 10.1097/RHU.0000000000001413 [doi]
AB  - OBJECTIVES: To examine the bone mineral density and prevalence of osteoporosis 
      and osteopenia in glucocorticoid- and immunosuppressive drug-naive patients 
      younger than 55 years with antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV). METHODS: This was a cross-sectional study. We reviewed the 
      medical records of 35 AAV patients and 35 age-, sex-, and body mass index 
      (BMI)-matched control subjects. We collected clinical data such as AAV-related 
      variables and conventional risk factors for osteoporosis and assessed bone 
      mineral density and the prevalence of osteoporosis and osteopenia in both groups. 
      Categorical and continuous variables were compared between the 2 groups using the 
      chi2 or Fisher exact test and Mann-Whitney U test, respectively. Multivariate 
      logistic regression analysis was used to calculate the odds ratio (OR). RESULTS: 
      There were no statistically significant differences between the demographical 
      data of AAV patients and control subjects. Patients with AAV showed significantly 
      higher frequencies of conventional risk factors for osteoporosis than the control 
      subjects, except for hyperthyroidism. Osteopenia was found more commonly in AAV 
      patients than in control subjects (57.1% vs. 31.4%, p = 0.030). In the univariate 
      logistic regression analysis, BMI (OR, 0.813) and AAV (OR, 2.620) were associated 
      with osteopenia in all participants. In the multivariate analysis, both BMI and 
      AAV were associated with osteopenia, but this was not statistically significant. 
      In contrast, when analyzing AAV patients only, neither conventional risk factors 
      nor AAV-related variables were associated with the prevalence of osteopenia. 
      CONCLUSIONS: Antineutrophil cytoplasmic antibody-associated vasculitis and BMI 
      were both associated with osteopenia.
CI  - Copyright (c) 2020 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Yoo, Byung-Woo
AU  - Yoo BW
AD  - From the Division of Rheumatology, Department of Internal Medicine.
FAU - Jung, Seung Min
AU  - Jung SM
AD  - From the Division of Rheumatology, Department of Internal Medicine.
FAU - Song, Jason Jungsik
AU  - Song JJ
FAU - Park, Yong-Beom
AU  - Park YB
FAU - Lee, Sang-Won
AU  - Lee SW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Rheumatol
JT  - Journal of clinical rheumatology : practical reports on rheumatic & 
      musculoskeletal diseases
JID - 9518034
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/diagnosis/epidemiology
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Osteoporosis/diagnosis/epidemiology
MH  - *Pharmaceutical Preparations
MH  - Prevalence
COIS- The authors report no conflicts of interest.
EDAT- 2020/06/13 06:00
MHDA- 2021/11/26 06:00
CRDT- 2020/06/13 06:00
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2020/06/13 06:00 [entrez]
AID - 00124743-202112000-00013 [pii]
AID - 10.1097/RHU.0000000000001413 [doi]
PST - ppublish
SO  - J Clin Rheumatol. 2021 Dec 1;27(8):e330-e335. doi: 10.1097/RHU.0000000000001413.