PMID- 32531030
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 22
IP  - 7
DP  - 2020 Jul 1
TI  - Relationship between quality of life and burden of recurrent atrial fibrillation 
      following ablation: CAPCOST multicentre cohort study.
PG  - 1017-1025
LID - 10.1093/europace/euaa066 [doi]
AB  - AIMS: Atrial fibrillation (AF) significantly impairs patients' quality of life 
      (QOL). We performed this study to investigate the effect of AF-ablation success 
      and atrial fibrillation burden (AFB) on QOL measures. METHODS AND RESULTS: 
      Overall, 230 patients with paroxysmal AF refractory to antiarrhythmic drugs were 
      enrolled and underwent ablation in a multicentre, prospective cohort. 
      Electrocardiogram, 48-h Holter, Canadian Cardiovascular Society Severity of 
      Atrial Fibrillation (CCS-SAF), short form-12 (SF-12), and Atrial Fibrillation 
      Effect on Quality of life (AFEQT) scales were used to assess patients. Atrial 
      fibrillation burden was defined as total duration of AF during the month prior to 
      each visit (h/month). The change in AFB was calculated as the difference between 
      the month prior to the 12-month post-ablation and the baseline pre-ablation. The 
      Minimal Clinically Important Difference (MCID) was considered as a 19-point 
      change for AFEQT and 3-5-point change for SF-12 scores. There was significant 
      rise in the AFEQT and SF12 and decrease in CCS-SAF score post-AF ablation; 
      however, the magnitude of these changes was greater in patients without AF 
      recurrence (P < 0.05). The QOL score that best differentiated patients with and 
      without recurrence was AFEQT, while, CCS-SAF was the most specific score. 
      Patients with AFB decrease >19 h/month had significantly greater change in QOL 
      scores. Atrial fibrillation burden < 24 h/month at 12-months post-ablation was 
      associated with significant changes in QOL and CCS-SAF when adjusting for 
      baseline scores and other covariates. These changes were consistent with the MCID 
      of these measures. CONCLUSION: Patients experience significant improvements in 
      QOL post-ablation, which correlate with a decrease in AFB despite ongoing brief 
      recurrences of AF. CLINICAL TRIAL REGISTRATION: NCT01562912. 
      https://www.clinicaltrials.gov/ct2/show/NCT01562912? term=capcost&rank=1.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.
FAU - Essebag, Vidal
AU  - Essebag V
AD  - McGill University Health Centre, Montreal, QC, Canada.
AD  - Hopital Sacre-Coeur de Montreal, Montreal, QC, Canada.
FAU - Azizi, Zahra
AU  - Azizi Z
AD  - Southlake Regional Health Centre, 602-581 Davis Drive, Newmarket, ON L3Y 2P6, 
      Canada.
AD  - Faculty of Health, York University, ON, Canada.
FAU - Alipour, Pouria
AU  - Alipour P
AD  - Southlake Regional Health Centre, 602-581 Davis Drive, Newmarket, ON L3Y 2P6, 
      Canada.
AD  - Faculty of Health, York University, ON, Canada.
FAU - Khaykin, Yaariv
AU  - Khaykin Y
AD  - Southlake Regional Health Centre, 602-581 Davis Drive, Newmarket, ON L3Y 2P6, 
      Canada.
FAU - Leong-Sit, Peter
AU  - Leong-Sit P
AD  - London Health Sciences Centre, London, ON, Canada.
FAU - Sarrazin, Jean-Francois
AU  - Sarrazin JF
AD  - Quebec Heart Institute, Montreal, QC, Canada.
FAU - Sturmer, Marcio
AU  - Sturmer M
AD  - Hopital Sacre-Coeur de Montreal, Montreal, QC, Canada.
FAU - Morillo, Carlos
AU  - Morillo C
AD  - Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, 
      Canada.
FAU - Terricabras, Maria
AU  - Terricabras M
AD  - Southlake Regional Health Centre, 602-581 Davis Drive, Newmarket, ON L3Y 2P6, 
      Canada.
FAU - Amit, Guy
AU  - Amit G
AD  - Hamilton Health Sciences, Hamilton, ON, Canada.
FAU - Roux, Jean Francois
AU  - Roux JF
AD  - Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
FAU - Patterson, Sherri
AU  - Patterson S
AD  - Southlake Regional Health Centre, 602-581 Davis Drive, Newmarket, ON L3Y 2P6, 
      Canada.
FAU - Verma, Atul
AU  - Verma A
AD  - Southlake Regional Health Centre, 602-581 Davis Drive, Newmarket, ON L3Y 2P6, 
      Canada.
LA  - eng
SI  - ClinicalTrials.gov/NCT01562912
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - *Atrial Fibrillation/diagnosis/surgery
MH  - Canada
MH  - *Catheter Ablation/adverse effects
MH  - Cohort Studies
MH  - Humans
MH  - Prospective Studies
MH  - Quality of Life
MH  - Recurrence
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Ablation
OT  - Atrial fibrillation
OT  - Atrial fibrillation burden
OT  - Minimal clinically important difference
OT  - Quality of life
OT  - Recurrence
EDAT- 2020/06/13 06:00
MHDA- 2021/06/29 06:00
CRDT- 2020/06/13 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2020/03/13 00:00 [accepted]
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/06/13 06:00 [entrez]
AID - 5856626 [pii]
AID - 10.1093/europace/euaa066 [doi]
PST - ppublish
SO  - Europace. 2020 Jul 1;22(7):1017-1025. doi: 10.1093/europace/euaa066.