PMID- 32531811
OWN - NLM
STAT- MEDLINE
DCOM- 20210810
LR  - 20210810
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 74
IP  - 11
DP  - 2020 Nov
TI  - Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens 
      neural atrophy as well as synaptophysin and GFAP stress in aging mice.
PG  - e22177
LID - 10.1002/syn.22177 [doi]
AB  - Recent reports on brain aging suggest that oxidative stress and inflammatory 
      processes contribute to aging. Interestingly, sodium phenylbutyrate (PBA) is an 
      inhibitor of histone deacetylase, which has anti-inflammatory properties. Several 
      reports have suggested the effect of PBA on learning and memory processes, 
      however there are no studies of the effect of this inhibitor of histone 
      deacetylase on aging. Consequently, in the present study, the effect of PBA was 
      studied in 18-month-old mice. The animals were administered PBA for 2 months 
      after locomotor activity treatment and Morris water maze tests were performed. 
      The Golgi-Cox staining technique and immunohistochemistry for glial fibrillary 
      acidic protein (GFAP) and synaptophysin were performed for the morphological 
      procedures. The administration of PBA improves learning and memory according to 
      the Morris water maze test compared to vehicle-treated animals, which had 
      unchanged locomotor activity. Using Golgi-Cox staining, dendritic length and the 
      number of dendritic spines were measured in limbic regions, such as the nucleus 
      accumbens (NAcc), prefrontal cortex (PFC) layer 3, and the CA1 of the dorsal 
      hippocampus. In addition, PBA increased the number of dendritic spines in the 
      PFC, NAcc, and CA1 subregions of the hippocampus with an increase in dendritic 
      length only in the CA1 region. Moreover, PBA reduced the levels of the GFAP and 
      increased the levels of synaptophysin in the studied regions. Thus, PBA can be a 
      useful pharmacological tool to prevent or delay synaptic plasticity damage and 
      cognitive impairment caused by age.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Carvajal-Flores, Fabiola Natividad
AU  - Carvajal-Flores FN
AUID- ORCID: 0000-0002-1832-7605
AD  - Laboratorio de Neuropsiquiatria, Instituto de Fisiologia, Benemerita Universidad 
      Autonoma de Puebla (BUAP), Puebla, Mexico.
FAU - Diaz, Alfonso
AU  - Diaz A
AUID- ORCID: 0000-0003-4092-6636
AD  - Departamento de Farmacia, Facultad de Ciencias Quimicas, Benemerita Universidad 
      Autonoma de Puebla (BUAP), Puebla, Mexico.
FAU - Flores-Gomez, Gabriel D
AU  - Flores-Gomez GD
AUID- ORCID: 0000-0002-2438-5772
AD  - Departamento de Ciencias de la Salud, Licenciatura en Medicina, Universidad de 
      las Americas Puebla, Cholula, Mexico.
FAU - de la Cruz, Fidel
AU  - de la Cruz F
AUID- ORCID: 0000-0001-8690-6070
AD  - Departamento de Fisiologia, Escuela Nacional de Ciencias Biologica, Instituto 
      Politecnico Nacional, Ciudad de Mexico, Mexico.
FAU - Flores, Gonzalo
AU  - Flores G
AUID- ORCID: 0000-0002-4100-2104
AD  - Laboratorio de Neuropsiquiatria, Instituto de Fisiologia, Benemerita Universidad 
      Autonoma de Puebla (BUAP), Puebla, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200701
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Phenylbutyrates)
RN  - 0 (Synaptophysin)
RN  - 0 (glial fibrillary astrocytic protein, mouse)
SB  - IM
MH  - Aging/*drug effects/metabolism/pathology
MH  - Animals
MH  - Dendritic Spines/drug effects/physiology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/*drug effects/growth & development/metabolism
MH  - Maze Learning
MH  - Mice
MH  - Neuronal Plasticity
MH  - Neuroprotective Agents/*pharmacology
MH  - Nucleus Accumbens/*drug effects/growth & development/metabolism
MH  - Phenylbutyrates/*pharmacology
MH  - Prefrontal Cortex/*drug effects/growth & development/metabolism
MH  - Synaptophysin/metabolism
OTO - NOTNLM
OT  - aging
OT  - dendrites
OT  - hippocampus
OT  - memory and learning
OT  - nucleus accumbens
OT  - prefrontal cortex
OT  - sodium phenylbutyrate
EDAT- 2020/06/13 06:00
MHDA- 2021/08/11 06:00
CRDT- 2020/06/13 06:00
PHST- 2020/03/27 00:00 [received]
PHST- 2020/06/07 00:00 [revised]
PHST- 2020/06/08 00:00 [accepted]
PHST- 2020/06/13 06:00 [pubmed]
PHST- 2021/08/11 06:00 [medline]
PHST- 2020/06/13 06:00 [entrez]
AID - 10.1002/syn.22177 [doi]
PST - ppublish
SO  - Synapse. 2020 Nov;74(11):e22177. doi: 10.1002/syn.22177. Epub 2020 Jul 1.