PMID- 32532020
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 6
DP  - 2020 Jun 10
TI  - Outpatient Pulmonary Rehabilitation in Patients with Persisting Symptoms after 
      Pulmonary Embolism.
LID - 10.3390/jcm9061811 [doi]
LID - 1811
AB  - Background: Patients with pulmonary embolism (PE) may suffer from long-term 
      consequences, including decreased functional capacity. Data on pulmonary 
      rehabilitation (PR) in patients with PE are scarce, and no data on outpatient PR 
      are available so far. Methods: We analyzed data of 22 PE patients who attended 
      outpatient PR due to exertional dyspnea. Patients underwent a multi-professional 
      6-week PR program. The primary outcome was change in 6-min walk test (6MWT). 
      Secondary outcomes included changes in strength and endurance tests. To assess 
      long-term benefits, follow-up was performed a median of 39 months after PR. 
      Results: Patients started PR a median of 19 weeks after the acute PE event. Their 
      median age was 47.5 years, 33% were women and all presented with NYHA (New York 
      Heart Association) class II and higher. After PR, patients showed significant and 
      clinically relevant improvements in 6MWT (mean difference: 49.4 m [95% CI 
      32.0-66.8]). Similarly, patients increased performance in maximum strength, 
      endurance and inspiratory muscle strength. At long-term follow-up, 78% of 
      patients reported improved health. Conclusion: We observed significant 
      improvements in exercise capacity in PE patients undergoing outpatient PR. The 
      majority of patients also reported a long-term improvement in health status. 
      Prospective studies are needed to identify patients who would benefit most from 
      structured PR.
FAU - Nopp, Stephan
AU  - Nopp S
AUID- ORCID: 0000-0002-4504-482X
AD  - Clinical Division of Haematology and Haemostaseology, Department of Medicine I, 
      Medical University of Vienna, 1090 Vienna, Austria.
FAU - Klok, Frederikus A
AU  - Klok FA
AD  - Department of Thrombosis and Hemostasis, Leiden University Medical Center, 2333 
      ZA Leiden, The Netherlands.
FAU - Moik, Florian
AU  - Moik F
AD  - Clinical Division of Haematology and Haemostaseology, Department of Medicine I, 
      Medical University of Vienna, 1090 Vienna, Austria.
FAU - Petrovic, Milos
AU  - Petrovic M
AD  - Outpatient Pulmonary Rehabilitation, Therme Wien Med, 1100 Vienna, Austria.
FAU - Derka, Irmgard
AU  - Derka I
AD  - Outpatient Pulmonary Rehabilitation, Therme Wien Med, 1100 Vienna, Austria.
FAU - Ay, Cihan
AU  - Ay C
AUID- ORCID: 0000-0003-2607-9717
AD  - Clinical Division of Haematology and Haemostaseology, Department of Medicine I, 
      Medical University of Vienna, 1090 Vienna, Austria.
AD  - I M Sechenov First Moscow State Medical University, 119146 Moscow, Russia.
FAU - Zwick, Ralf Harun
AU  - Zwick RH
AD  - Outpatient Pulmonary Rehabilitation, Therme Wien Med, 1100 Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20200610
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7355580
OTO - NOTNLM
OT  - dyspnea
OT  - exercise training
OT  - outpatient
OT  - pulmonary embolism
OT  - pulmonary rehabilitation
COIS- The authors declare no conflict of interest.
EDAT- 2020/06/14 06:00
MHDA- 2020/06/14 06:01
PMCR- 2020/06/10
CRDT- 2020/06/14 06:00
PHST- 2020/05/03 00:00 [received]
PHST- 2020/05/28 00:00 [revised]
PHST- 2020/06/09 00:00 [accepted]
PHST- 2020/06/14 06:00 [entrez]
PHST- 2020/06/14 06:00 [pubmed]
PHST- 2020/06/14 06:01 [medline]
PHST- 2020/06/10 00:00 [pmc-release]
AID - jcm9061811 [pii]
AID - jcm-09-01811 [pii]
AID - 10.3390/jcm9061811 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jun 10;9(6):1811. doi: 10.3390/jcm9061811.