PMID- 32532068
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 12
IP  - 6
DP  - 2020 Jun 10
TI  - Beneficial Molecular Adaptations In BRCA-Mutation Carriers By Combined HIT/HIRT 
      Intervention: Results From A Pilot Study.
LID - 10.3390/cancers12061526 [doi]
LID - 1526
AB  - : Based on growing evidence that breast cancer (BRCA) also plays a pivotal role 
      in the regulation of skeletal muscle metabolism and the response to 
      anti-oxidative stress, we examined the influence of regular exercise in human 
      BRCA mutation carriers on their BRCA1 gene/protein expression and 
      inflammatory/oxidative response. Sixteen BRCA-mutation carriers were assigned to 
      an intervention (IG) or control group (CG). IG received a combination of 
      high-intensity interval endurance (HIT) and strength training (HIRT) for six 
      weeks, whereas CG received a low-intensity activity program. Before (T0) and at 
      the end of the intervention (T1), muscle biopsy, physiological performance, blood 
      withdrawal and anthropometry were obtained. Parameters included: Muscle BRCA1 
      gene/protein expression, inflammatory/oxidative stress, anti-oxidative capacity, 
      peak oxygen capacity (VO(2)peak) and 1-repetition maximum (1-RM) at six different 
      training machines. VO(2)peak and 1-RM of IG were increased at T1 compared to T0, 
      whereas CG performance, physiological and molecular parameters remained 
      unchanged. IG showed increased BRCA1 protein concentration as well as 
      anti-oxidative capacity, whereas gene expression was unaltered. IG inflammatory 
      and oxidative damage did not differ between time points. Combined HIT/HIRT 
      increases aerobic and strength performance of BRCA-mutation carriers with up 
      regulated BRCA1 protein expression and improved anti-oxidative status without 
      showing an increased inflammatory response.
FAU - Bizjak, Daniel A
AU  - Bizjak DA
AD  - Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 
      Ulm, Germany.
FAU - Schulz, Sebastian V W
AU  - Schulz SVW
AD  - Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 
      Ulm, Germany.
FAU - Schumann, Uwe
AU  - Schumann U
AD  - Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 
      Ulm, Germany.
FAU - Otto, Stephanie
AU  - Otto S
AD  - Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 
      Ulm, Germany.
FAU - Kirsten, Johannes
AU  - Kirsten J
AD  - Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 
      Ulm, Germany.
FAU - Ebner, Florian
AU  - Ebner F
AD  - Ulm University Hospital, Department of Gynecology and Obstetrics, 89075 Ulm, 
      Germany.
FAU - Leinert, Elena
AU  - Leinert E
AD  - Ulm University Hospital, Department of Gynecology and Obstetrics, 89075 Ulm, 
      Germany.
FAU - Huober, Jens
AU  - Huober J
AD  - Ulm University Hospital, Department of Gynecology and Obstetrics, 89075 Ulm, 
      Germany.
FAU - Janni, Wolfgang
AU  - Janni W
AD  - Ulm University Hospital, Department of Gynecology and Obstetrics, 89075 Ulm, 
      Germany.
FAU - Steinacker, Jurgen Michael
AU  - Steinacker JM
AD  - Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 
      Ulm, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200610
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7352264
OTO - NOTNLM
OT  - BRCA protein/gene expression
OT  - BRCA1 mutation
OT  - anti-oxidative stress/inflammatory response
OT  - combination HIT/HIRT program
OT  - molecular adaptations
COIS- The authors declare no conflict of interest.
EDAT- 2020/06/14 06:00
MHDA- 2020/06/14 06:01
PMCR- 2020/06/10
CRDT- 2020/06/14 06:00
PHST- 2020/04/27 00:00 [received]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/06/06 00:00 [accepted]
PHST- 2020/06/14 06:00 [entrez]
PHST- 2020/06/14 06:00 [pubmed]
PHST- 2020/06/14 06:01 [medline]
PHST- 2020/06/10 00:00 [pmc-release]
AID - cancers12061526 [pii]
AID - cancers-12-01526 [pii]
AID - 10.3390/cancers12061526 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Jun 10;12(6):1526. doi: 10.3390/cancers12061526.