PMID- 32532452
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1535-6280 (Electronic)
IS  - 0146-2806 (Linking)
VI  - 46
IP  - 3
DP  - 2021 Mar
TI  - Characteristics and Outcomes of Pulmonary Angioplasty With or Without Stenting 
      for Sarcoidosis-Associated Pulmonary Hypertension: Systematic Review and 
      Individual Participant Data Meta-Analysis.
PG  - 100616
LID - S0146-2806(20)30093-1 [pii]
LID - 10.1016/j.cpcardiol.2020.100616 [doi]
AB  - BACKGROUND: Pulmonary angioplasty has been performed in patients with 
      sarcoidosis-associated pulmonary hypertension (SAPH) but most evidence comes from 
      case reports and small case series. Overall outcomes remain unclear. We conducted 
      an individual participant data (IPD) meta-analysis of baseline, procedural, and 
      outcome data of pulmonary angioplasty in patients with SAPH. METHODS: We 
      performed searches and systematically reviewed references from PubMed, Embase, 
      Cochrane, ClinicalTrials.gov, and grey literature. We included IPD of patients 
      who underwent pulmonary angioplasty for SAPH. Those without definitive diagnosis 
      of sarcoidosis or with other causes of pulmonary vascular stenosis or compression 
      were excluded. RESULTS: Of 1293 screened references, 7 were included. IPD was 
      obtained for 17 patients (mean age 58.6 (+/-9.1) years; 82.4% female); most of whom 
      were Scadding stages III or IV and had NYHA FC III or IV. All patients with 
      documented changes in 6-minute-walk distance (6MWD) had a significant improvement 
      that ranged from 12.6 to 102.4% (P < 0.01). There were no deaths during a median 
      follow-up of 6 (3-18) months. CONCLUSIONS: Pulmonary angioplasty with or without 
      stenting of focal stenosis or compressions of pulmonary vessels may lead to 
      significant improvement in 6MWD in patients with SAPH. However, this study had a 
      small sample and some methodological limitations, such as analysis mostly of case 
      reports and series. Randomized controlled clinical trials and/or large 
      multicenter registry studies are needed to provide higher evidence in this topic.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - daSilva-deAbreu, Adrian
AU  - daSilva-deAbreu A
AD  - John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, New 
      Orleans, LA; The University of Queensland Ochsner Clinical School, Faculty of 
      Medicine, The University of Queensland, New Orleans, LA. Electronic address: 
      adrianjdasilva@gmail.com.
FAU - Bracamonte-Baran, William
AU  - Bracamonte-Baran W
AD  - Department of Internal Medicine, Texas Tech University Health Science Center at 
      the Permian Basin, Odessa, TX.
FAU - Condado, Jose F
AU  - Condado JF
AD  - Emory Structural Heart and Valve Center, Division of Cardiology, Emory University 
      School of Medicine, Atlanta, GA.
FAU - Babaliaros, Vasilis
AU  - Babaliaros V
AD  - Emory Structural Heart and Valve Center, Division of Cardiology, Emory University 
      School of Medicine, Atlanta, GA.
FAU - Tafur-Soto, Jose
AU  - Tafur-Soto J
AD  - John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, New 
      Orleans, LA; The University of Queensland Ochsner Clinical School, Faculty of 
      Medicine, The University of Queensland, New Orleans, LA.
FAU - Mandras, Stacy A
AU  - Mandras SA
AD  - John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, New 
      Orleans, LA; The University of Queensland Ochsner Clinical School, Faculty of 
      Medicine, The University of Queensland, New Orleans, LA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200519
PL  - Netherlands
TA  - Curr Probl Cardiol
JT  - Current problems in cardiology
JID - 7701802
SB  - IM
MH  - *Angioplasty
MH  - Female
MH  - Humans
MH  - *Hypertension, Pulmonary/surgery/therapy
MH  - Male
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - *Sarcoidosis/surgery/therapy
MH  - Stents
COIS- Declaration of Competing Interest None.
EDAT- 2020/06/14 06:00
MHDA- 2021/07/16 06:00
CRDT- 2020/06/14 06:00
PHST- 2020/04/18 00:00 [received]
PHST- 2020/04/21 00:00 [accepted]
PHST- 2020/06/14 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2020/06/14 06:00 [entrez]
AID - S0146-2806(20)30093-1 [pii]
AID - 10.1016/j.cpcardiol.2020.100616 [doi]
PST - ppublish
SO  - Curr Probl Cardiol. 2021 Mar;46(3):100616. doi: 10.1016/j.cpcardiol.2020.100616. 
      Epub 2020 May 19.