PMID- 32532652
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20201130
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 223
DP  - 2020 Aug
TI  - Relationships between Early Nutrition, Illness, and Later Outcomes among Infants 
      Born Preterm with Hyperglycemia.
PG  - 29-33.e2
LID - S0022-3476(20)30493-5 [pii]
LID - 10.1016/j.jpeds.2020.04.038 [doi]
AB  - OBJECTIVE: To evaluate the effects of hyperglycemia on body composition and 
      neurodevelopment, and how early nutrition and illness modify these relationships 
      in infants born preterm. STUDY DESIGN: Prospective data were collected from 
      infants born <32 weeks of gestational age (N = 97), including inpatient days of 
      hyperglycemia (blood glucose >150 mg/dL) and nutrient intake. Body composition 
      was measured at discharge and 4 months' postmenstrual age (PMA). Bayley Scales of 
      Infant Development III (BSID-III) were administered at 12 months' PMA. Linear 
      regression analysis was performed, adjusting for birth gestational age. 
      Associations between hyperglycemia, body composition, and BSID-III were analyzed 
      in models accounting for first-week nutrition and early illness severity via 
      Score for Neonatal Acute Physiology-II. RESULTS: Mean birth gestational age was 
      27.8 (SD 2.4) weeks. Hyperglycemia occurred in 48.5% of infants. Hyperglycemia 
      for >/=5 days was negatively associated with fat mass and fat free mass z scores at 
      discharge, and fat free mass z score at 4 months' PMA (P < .05 all). 
      Hyperglycemia for >/=5 days was negatively associated with cognition, language, and 
      motor scores on the BSDI at 12 months (P </= .01 all). Associations with body 
      composition and BSID-III were diminished when models included first week 
      nutrition yet remained unchanged when illness severity was included. CONCLUSIONS: 
      In infants <32 weeks, >/=5 days of hyperglycemia is associated with decreased lean 
      mass at 4 months' PMA and poorer neurodevelopmental outcome at 12 months' PMA. 
      These associations may be mediated by decreased first week nutrition, potentially 
      related to reduced glucose infusion rate for management of hyperglycemia.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Gonzalez Villamizar, Juan David
AU  - Gonzalez Villamizar JD
AD  - Department of Pediatrics, Division of Neonatology, School of Medicine, University 
      of Minnesota, Minneapolis, MN. Electronic address: gonz0241@umn.edu.
FAU - Haapala, Jacob L
AU  - Haapala JL
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, MN.
FAU - Scheurer, Johannah M
AU  - Scheurer JM
AD  - Department of Pediatrics, Division of Neonatology, School of Medicine, University 
      of Minnesota, Minneapolis, MN.
FAU - Rao, Raghavendra
AU  - Rao R
AD  - Department of Pediatrics, Division of Neonatology, School of Medicine, University 
      of Minnesota, Minneapolis, MN.
FAU - Ramel, Sara E
AU  - Ramel SE
AD  - Department of Pediatrics, Division of Neonatology, School of Medicine, University 
      of Minnesota, Minneapolis, MN.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200609
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Adiposity
MH  - Body Composition
MH  - *Child Development
MH  - *Energy Intake
MH  - Female
MH  - Humans
MH  - Hyperglycemia/*diet therapy
MH  - Infant
MH  - *Infant Nutritional Physiological Phenomena
MH  - Infant, Newborn
MH  - Infant, Premature/*growth & development
MH  - Infant, Premature, Diseases/diet therapy
MH  - Infant, Very Low Birth Weight/growth & development
MH  - Male
MH  - Prospective Studies
OTO - NOTNLM
OT  - body composition
OT  - infant
OT  - neurodevelopment
OT  - prematurity
EDAT- 2020/06/14 06:00
MHDA- 2020/12/01 06:00
CRDT- 2020/06/14 06:00
PHST- 2020/01/03 00:00 [received]
PHST- 2020/03/12 00:00 [revised]
PHST- 2020/04/15 00:00 [accepted]
PHST- 2020/06/14 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2020/06/14 06:00 [entrez]
AID - S0022-3476(20)30493-5 [pii]
AID - 10.1016/j.jpeds.2020.04.038 [doi]
PST - ppublish
SO  - J Pediatr. 2020 Aug;223:29-33.e2. doi: 10.1016/j.jpeds.2020.04.038. Epub 2020 Jun 
      9.