PMID- 32534365
OWN - NLM
STAT- MEDLINE
DCOM- 20201104
LR  - 20201104
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 95
DP  - 2020 Aug
TI  - t(3;14)(p14.1;q32)/FOXP1-IGH translocation in thyroid extranodal marginal zone 
      lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).
PG  - 106399
LID - S0145-2126(20)30104-1 [pii]
LID - 10.1016/j.leukres.2020.106399 [doi]
AB  - OBJECTIVES: MALT lymphoma occurs in various organs and has several characteristic 
      genetic aberrations. Thyroid MALT lymphoma has been reported to include 
      t(3;14)(p14.1;q32)/FOXP1-IGH as a specific genetic aberration, but the number of 
      studies is limited. METHOD AND RESULTS: We examined 86 thyroid lymphoma cases 
      using fluorescence in situ hybridization (FISH) for the detection of 
      t(3;14)/FOXP1-IGH in formalin fixed paraffin-embedded tissue (FFPE). 
      Histopathological diagnoses of the analyzed specimen were as follows: thyroid 
      MALT lymphoma (n = 59), DLBCL (n = 23), follicular lymphoma (n = 4), and benign 
      lesions (n = 14) included Hashimoto's thyroiditis (n = 13) and other (n = 1). Of 
      the 100 analyzed cases, thirty-six (36 %) thyroid lymphoma cases were positive 
      for t(3;14)/FOXP1-IGH. Thirty-three (55.9 %) of the 59 MALT lymphoma cases were 
      positive for t(3;14)/FOXP1-IGH. Three (13.0 %) of the 23 DLBCL cases were 
      positive for t(3;14)/FOXP1-IGH. All 4 follicular lymphomas examined were negative 
      for t(3;14)/FOXP1-IGH. None of the benign cases was positive for 
      t(3;14)/FOXP1-IGH, including Hashimoto's thyroiditis (0/13) and benign tissue 
      (0/1). CONCLUSIONS: Our study found that t(3;14)/FOXP1-IGH was frequently found 
      in thyroid MALT lymphoma. A detection of t(3;14)/FOXP1-IGH is extremely useful 
      for the differential diagnosis between primary MALT lymphoma of the thyroid and 
      other thyroid disorders.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Sasaki, Yosuke
AU  - Sasaki Y
AD  - Department of Pathology, Showa University School of Medicine, Japan. Electronic 
      address: sasaki0224@med.showa-u.ac.jp.
FAU - Shiozawa, Eisuke
AU  - Shiozawa E
AD  - Department of Pathology, Showa University School of Medicine, Japan.
FAU - Watanabe, Natsuko
AU  - Watanabe N
AD  - Ito Hospital, Japan.
FAU - Homma, Mayumi
AU  - Homma M
AD  - Department of Pathology, Showa University School of Medicine, Japan.
FAU - Noh, Jaeduk Yoshimura
AU  - Noh JY
AD  - Ito Hospital, Japan.
FAU - Ito, Koichi
AU  - Ito K
AD  - Ito Hospital, Japan.
FAU - Takimoto, Masafumi
AU  - Takimoto M
AD  - Department of Pathology, Showa University School of Medicine, Japan.
FAU - Yamochi-Onizuka, Toshiko
AU  - Yamochi-Onizuka T
AD  - Department of Pathology, Showa University School of Medicine, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200602
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (FOXP1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Forkhead Transcription Factors/*genetics
MH  - Genes, Immunoglobulin Heavy Chain/*genetics
MH  - Humans
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Male
MH  - Middle Aged
MH  - Oncogene Fusion/*genetics
MH  - Repressor Proteins/*genetics
MH  - Thyroid Neoplasms/*genetics
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - Chromosomal translocation
OT  - FOXP1
OT  - MALT lymphoma
OT  - Thyroid lymphoma
OT  - t(3;14)(p14.1;q32)/FOXP1-IGH
EDAT- 2020/06/14 06:00
MHDA- 2020/11/05 06:00
CRDT- 2020/06/14 06:00
PHST- 2020/04/11 00:00 [received]
PHST- 2020/05/28 00:00 [revised]
PHST- 2020/05/30 00:00 [accepted]
PHST- 2020/06/14 06:00 [pubmed]
PHST- 2020/11/05 06:00 [medline]
PHST- 2020/06/14 06:00 [entrez]
AID - S0145-2126(20)30104-1 [pii]
AID - 10.1016/j.leukres.2020.106399 [doi]
PST - ppublish
SO  - Leuk Res. 2020 Aug;95:106399. doi: 10.1016/j.leukres.2020.106399. Epub 2020 Jun 
      2.