PMID- 32534597 OWN - NLM STAT- MEDLINE DCOM- 20210414 LR - 20210414 IS - 1477-7819 (Electronic) IS - 1477-7819 (Linking) VI - 18 IP - 1 DP - 2020 Jun 13 TI - Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma. PG - 128 LID - 10.1186/s12957-020-01902-y [doi] LID - 128 AB - BACKGROUND: Deletions of 17p13 recurrently occur in renal cell carcinoma (RCC) but their prognostic role seems to be uncertain. METHODS: To determine prevalence, relationship with tumor phenotype, and patient prognosis, a tissue microarray containing samples from 1809 RCCs was evaluated using dual labeling fluorescence in situ hybridization (FISH) with 17p13 and chromosome 17 centromere probes. RESULTS: A 17p13 deletion was found in 72 of 1429 interpretable tumors. The frequency of 17p13 deletions varied greatly between RCC subtypes and was highest in chromophobe RCC (24/72; 33.3%). 17p13 deletions were also found in 35 (3.7%) of 946 clear cell RCC, 9 (4.3%) of 208 papillary RCC, 1 of 121 oncocytomas (0.8%), as well as in several rare cases of comprising 1 of 7 Xp11.2 translocation cancers, 1 of 3 collecting duct carcinomas, and 1 of 20 not otherwise specified (NOS) carcinomas. In clear cell carcinomas, 17p13 deletions revealed a strong and consistent association with higher Fuhrman, ISUP, and Thoenes grade (p < 0.0001 each), and linked to advanced tumor stage (p = 0.0168), large tumor diameter (p = 0.0004), distant metastases (p = 0.0077), cancer-specific survival (p = 0.0391), and recurrence-free survival (p = 0.0072). In multivariate analysis, 17p13 deletions showed in clear cell RCC a dependent prognostic role for established clinical-pathological parameters. CONCLUSION: 17p13 deletions have a dual role in RCC. They are associated with disease progression in clear cell RCC and possibly other subtypes and they are linked to the development of chromophobe RCC-a subtype with a particularly favorable prognosis. FAU - Eichenauer, Till AU - Eichenauer T AD - Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Shadanpour, Navid AU - Shadanpour N AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Kluth, Martina AU - Kluth M AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Gobel, Cosima AU - Gobel C AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Weidemann, Soren AU - Weidemann S AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Fraune, Christoph AU - Fraune C AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Buscheck, Franziska AU - Buscheck F AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Hube-Magg, Claudia AU - Hube-Magg C AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Moller-Koop, Christina AU - Moller-Koop C AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Dahlem, Roland AU - Dahlem R AD - Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Fisch, Margit AU - Fisch M AD - Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Rink, Michael AU - Rink M AD - Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Riechardt, Silke AU - Riechardt S AD - Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Burandt, Eike AU - Burandt E AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Bernreuther, Christian AU - Bernreuther C AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Minner, Sarah AU - Minner S AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Simon, Ronald AU - Simon R AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. R.Simon@uke.de. FAU - Sauter, Guido AU - Sauter G AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Wilczak, Waldemar AU - Wilczak W AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. FAU - Clauditz, Till AU - Clauditz T AD - Institute of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. LA - eng PT - Journal Article DEP - 20200613 PL - England TA - World J Surg Oncol JT - World journal of surgical oncology JID - 101170544 SB - IM MH - Carcinoma, Renal Cell/*genetics/pathology MH - *Chromosome Deletion MH - *Chromosomes, Human, Pair 17 MH - Humans MH - In Situ Hybridization, Fluorescence/methods MH - Kidney Neoplasms/*genetics/pathology MH - Phenotype MH - Prognosis MH - Survival Rate MH - Tissue Array Analysis/methods PMC - PMC7293794 OTO - NOTNLM OT - 17p13 deletion OT - Fluorescence in situ hybridization OT - Prognosis OT - Renal cell cancer OT - Tissue microarray COIS- The authors declare they have no competing interests. EDAT- 2020/06/15 06:00 MHDA- 2021/04/15 06:00 PMCR- 2020/06/13 CRDT- 2020/06/15 06:00 PHST- 2020/03/15 00:00 [received] PHST- 2020/06/02 00:00 [accepted] PHST- 2020/06/15 06:00 [entrez] PHST- 2020/06/15 06:00 [pubmed] PHST- 2021/04/15 06:00 [medline] PHST- 2020/06/13 00:00 [pmc-release] AID - 10.1186/s12957-020-01902-y [pii] AID - 1902 [pii] AID - 10.1186/s12957-020-01902-y [doi] PST - epublish SO - World J Surg Oncol. 2020 Jun 13;18(1):128. doi: 10.1186/s12957-020-01902-y.