PMID- 32535618
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 50
IP  - 2
DP  - 2021 May 17
TI  - Obstetric oxytocin exposure and ADHD and ASD among Danish and Finnish children.
PG  - 446-456
LID - 10.1093/ije/dyaa076 [doi]
AB  - BACKGROUND: Some studies have indicated an increased risk of attention deficit 
      hyperactivity disorder (ADHD) and a small, sex-specific association with autism 
      spectrum disorder (ASD) among children prenatally exposed to obstetric oxytocin. 
      Since oxytocin is widely used in the obstetric ward, these potentially 
      deleterious effects are of concern. Thus, we aimed to examine whether obstetric 
      oxytocin treatment for labour induction or augmentation is associated with ADHD 
      and ASD in offspring born in a two-country design based on data from Denmark and 
      Finland. METHODS: This population-based study used data from national registers 
      in Denmark and Finland. Singletons born in Denmark 2000-10 (n = 577 380) and 
      Finland 1991-2010 (n = 945 543), who survived infancy, were followed until 31 
      December 2015. ADHD and ASD were defined using diagnostic codes. For ADHD, we 
      also included information on prescribed and redeemed ADHD medication in the 
      definition. Hazards ratios (HRs) with 95% confidence intervals (CI), modelled 
      with age as the underlying time scale, were calculated to estimate the 
      associations. RESULTS: Oxytocin was used in 31% and 46% of the included 
      deliveries in Denmark and Finland, respectively. In crude analyses, prenatal 
      oxytocin was associated with an approximately 20% increased risk of ADHD and ASD, 
      but confounder adjustment attenuated the association. The adjusted HR was 1.03, 
      95% CI 1.01-1.05, for ADHD and 1.05, 95% CI 1.02-1.08, for ASD. The results were 
      similar in across country and gender. CONCLUSIONS: We found an association 
      between synthetic oxytocin and ADHD or ASD which is unlikely to reflect a causal 
      association and thus should not support the concern of clinical use. Our results 
      help to allay concerns of obstetric use of oxytocin causing ADHD or ASD.
CI  - (c) The Author(s) 2020; all rights reserved. Published by Oxford University Press 
      on behalf of the International Epidemiological Association.
FAU - Stokholm, Lonny
AU  - Stokholm L
AUID- ORCID: 0000-0002-9727-6649
AD  - Section of Epidemiology, Department of Public Health, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Juhl, Mette
AU  - Juhl M
AD  - Department of Midwifery, Copenhagen University College, Copenhagen, Denmark.
FAU - Talge, Nicole M
AU  - Talge NM
AD  - Department of Epidemiology and Biostatistics, Michigan State University, East 
      Lansing, MI, USA.
FAU - Gissler, Mika
AU  - Gissler M
AD  - Department of Information Services, THL Finnish Institute for Health and Welfare, 
      Helsinki, Finland.
AD  - Research Centre for Child Psychiatry, University of Turku, Turku, Finland.
AD  - Division of Family Medicine, Department of Neurobiology, Care Sciences and 
      Society, Karolinska Institute, Stockholm, Sweden.
FAU - Obel, Carsten
AU  - Obel C
AD  - Section for General Medical Practice, Department of Public Health, Aarhus 
      University, Aarhus, Denmark.
FAU - Strandberg-Larsen, Katrine
AU  - Strandberg-Larsen K
AD  - Section of Epidemiology, Department of Public Health, University of Copenhagen, 
      Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 50-56-6 (Oxytocin)
SB  - IM
CIN - Int J Epidemiol. 2021 May 17;50(2):457-458. PMID: 34000735
MH  - *Attention Deficit Disorder with Hyperactivity/chemically induced/drug 
      therapy/epidemiology
MH  - *Autism Spectrum Disorder/chemically induced/epidemiology
MH  - Child
MH  - Denmark/epidemiology
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Male
MH  - Oxytocin/adverse effects
MH  - Pregnancy
OTO - NOTNLM
OT  - Attention deficit hyperactivity deficits
OT  - autism spectrum disorder
OT  - cross-national
OT  - oxytocin
EDAT- 2020/06/15 06:00
MHDA- 2021/07/08 06:00
CRDT- 2020/06/15 06:00
PHST- 2020/04/06 00:00 [accepted]
PHST- 2020/06/15 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2020/06/15 06:00 [entrez]
AID - 5857280 [pii]
AID - 10.1093/ije/dyaa076 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2021 May 17;50(2):446-456. doi: 10.1093/ije/dyaa076.