PMID- 32536094
OWN - NLM
STAT- MEDLINE
DCOM- 20200812
LR  - 20200812
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 100
IP  - 22
DP  - 2020 Jun 9
TI  - [Changes of retinal structure after systemic immunosuppressive treatment in eyes 
      with Vogt-Koyanagi-Harada disease].
PG  - 1725-1729
LID - 10.3760/cma.j.cn112137-20200212-00265 [doi]
AB  - Objective: To assess structural changes in retina after systemic 
      immunosuppressive treatment in Vogt-Koyanagi-Harada (VKH) disease using 
      spectral-domain optical coherence tomography (SD-OCT). Methods: The clinical data 
      of 17 VKH cases (34 eyes) who consecutively attended the Beijing Tongren Hospital 
      between December 2015 and December 2019 were retrospectively reviewed. All the 
      patients had acute or subacute onset, and underwent high-dose systemic 
      corticosteroid and/or immunosuppressive treatment, with a followed-up time of at 
      least 6 months. At the end of follow-up, the intraocular inflammation was 
      controlled, and oral prednisone was withdrawn or being adjusted to less than 10 
      mg/day. The SD-OCT features of the included eyes were analyzed before treatment, 
      1 week, 1 month and 3 months after treatment, and at the last visit. Results: A 
      total of 17 cases (34 eyes; 6 males and 11 females) were included, with an age of 
      (42.2+/-10.6) years, and were followed up for (9.4+/-3.3) months. At 1 week after 
      initiating treatment, the percentage of the eyes with extensive/multiple or 
      multifocal retinal detachment in the macular region, membranous structures and 
      intraretinal cysts, and undulations and bumps of retinal pigment epithelium (RPE) 
      decreased (5.9% vs 100%, 2.9% vs 47.1%, 5.9% vs 70.6%, 11.8% vs 58.8%, 
      respectively, all P<0.001). There was statistical significant difference of the 
      percentage of ellipsoid zone and external limiting membrane (ELM) disruptions 
      before treatment, at 3 months and the last visit (100% vs 35.3%, 64.7% vs 52.9%, 
      41.2% vs 26.5%, respectively, all P<0.001). At the last visit, there were 
      statistical significant differences of the best corrected vision acuity (BCVA) 
      between the intact ellipsoid zone group (20 eyes) and the discontinuous group (14 
      eyes), as well as between the intact ELM group (25 eyes) and the discontinuous 
      group (9 eyes), respectively [0 (0, 0.05) vs 0.10 (0.03, 0.33) (log MAR), 
      P=0.004; 0 (0, 0.07) vs 0.22 (0.05, 0.40) (log MAR), P=0.005]. Conclusions: The 
      edema of choroid and retina subsided obviously at 1 week after initiating 
      treatment. The extent of damage and recovery ability of ellipsoid zone and ELM 
      were different before treatment, at 3 months and the last visit. At the last 
      visit, the outer retinal layers failed to recover completely in some patients, 
      and were related to the BCVA.
FAU - Cao, X S
AU  - Cao XS
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.
FAU - Zhang, Y P
AU  - Zhang YP
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.
FAU - Ji, H X
AU  - Ji HX
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.
FAU - Jiao, X
AU  - Jiao X
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.
FAU - Wang, H
AU  - Wang H
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.
LA  - chi
GR  - 7122042/Beijing Municipal Natural Science Foundation/
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - *Uveomeningoencephalitic Syndrome
OTO - NOTNLM
OT  - Glucocorticoids
OT  - Tomography, optical coherence
OT  - Uveomeningoencephalitic syndrome
EDAT- 2020/06/17 06:00
MHDA- 2020/08/13 06:00
CRDT- 2020/06/16 06:00
PHST- 2020/06/16 06:00 [entrez]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2020/08/13 06:00 [medline]
AID - 10.3760/cma.j.cn112137-20200212-00265 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2020 Jun 9;100(22):1725-1729. doi: 
      10.3760/cma.j.cn112137-20200212-00265.