PMID- 32536835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1611-2156 (Print)
IS  - 1611-2156 (Electronic)
IS  - 1611-2156 (Linking)
VI  - 19
DP  - 2020
TI  - Aloin promotes cell apoptosis by targeting HMGB1-TLR4-ERK axis in human melanoma 
      cells.
PG  - 641-651
AB  - Aloin (ALO) is the major anthraquinone glycoside purified from the Aloe species. 
      It is well known for its anti-tumor effects. However, the protective effects of 
      ALO in melanoma cancer and underlying molecular mechanism remain unclear. 
      High-mobility group protein B1 (HMGB1) is an intracellular protein, which has 
      closely association with cell survival, proliferation and metastasis in various 
      cancers. In this study, we explored the effect of ALO on cell survival and 
      apoptosis by targeting HMGB1 signal pathway. We confirmed that ALO exerts a 
      strong effect on promoting cell apoptosis of melanoma cells in vitro. 
      Furthermore, HMGB1 release was significantly inhibited in melanoma cancer cells 
      treated with ALO. Knockdown of HMGB1 could enhance melanoma cell death that is 
      induced by ALO treatment. Moreover, HMGB1 facilitated ALO mediated melanoma cell 
      apoptosis by binding to its receptor, Toll-like receptor 4 and activating 
      extracellular regulated protein kinases (ERK) signal pathway. Altogether, our 
      study demonstrated that ALO plays an important role in promoting apoptosis of 
      melanoma cells by inhibiting HMGB1 release and activation of downstream ERK 
      signal pathway.
CI  - Copyright (c) 2020 Li et al.
FAU - Li, Pan
AU  - Li P
AD  - Medical Research Institute, Northwestern Polytechnical University, Xi'an, China.
AD  - Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
FAU - Ren, Kai
AU  - Ren K
AD  - Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
FAU - Liang, Yin Yin
AU  - Liang YY
AD  - Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
FAU - Liu, Ji Kai
AU  - Liu JK
AD  - Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
FAU - Liang, Zhuo Wen
AU  - Liang ZW
AD  - Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
FAU - Zhang, Yong Feng
AU  - Zhang YF
AD  - Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical 
      University, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20200514
PL  - Germany
TA  - EXCLI J
JT  - EXCLI journal
JID - 101299402
PMC - PMC7290104
OTO - NOTNLM
OT  - Aloin
OT  - ERK signal pathway
OT  - HMGB1
OT  - apoptosis
OT  - melanoma
EDAT- 2020/06/17 06:00
MHDA- 2020/06/17 06:01
PMCR- 2020/05/14
CRDT- 2020/06/16 06:00
PHST- 2020/01/10 00:00 [received]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/06/16 06:00 [entrez]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2020/06/17 06:01 [medline]
PHST- 2020/05/14 00:00 [pmc-release]
AID - 2020-1043 [pii]
AID - Doc641 [pii]
PST - epublish
SO  - EXCLI J. 2020 May 14;19:641-651. eCollection 2020.