PMID- 32539571
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20220427
IS  - 1784-973X (Electronic)
IS  - 0001-5385 (Linking)
VI  - 76
IP  - 7
DP  - 2021 Sep
TI  - 15-Year follow-up of regional right and left ventricular function after the 
      Senning operation: a Colour-Doppler myocardial imaging study.
PG  - 689-696
LID - 10.1080/00015385.2020.1770459 [doi]
AB  - INTRODUCTION: Despite right ventricular (RV) dysfunction being a major concern in 
      Senning patients, long-term follow-up data is lacking. This study aimed (1) at 
      evaluating regional (base-mid-apex) RV and left ventricular (LV) function using 
      Colour-Doppler myocardial imaging over a 15-year follow-up period and (2) at 
      comparing results with matched controls. METHODS: For the longitudinal analysis 
      (2004-2019), we compared systolic and diastolic function in 10 Senning patients. 
      For the cross-sectional analysis, we compared the subaortic RV (sRV) of Senning 
      patients with the RV and LV of matched controls and the subpulmonary LV (spLV) of 
      Senning patients with the LV of matched controls. RESULTS: The longitudinal 
      analysis of sRV function showed a significant decrease in apical peak systolic 
      strain (-17 +/- 7% vs -12 +/- 4%; p = 0.025) and apical peak systolic strain rate 
      (-1.1 +/- 0.3s(-1) vs -0.8 +/- 0.4s(-1); p = 0.012). spLV function showed a 
      significant decrease in peak systolic velocity (mid; p = 0.013 and apex; 
      p = 0.011) and peak systolic strain rate (mid; p = 0.048). The cross-sectional 
      analysis revealed significant lower values for basal, mid and apical peak 
      systolic velocity, peak systolic strain rate, peak systolic strain of the sRV of 
      Senning patients when compared to both LV and RV of matched controls (all 
      p < 0.05). CONCLUSION: Our study showed that systolic and diastolic sRV function 
      did not change over a 15-year follow-up period, except in the apical region. 
      There was a decline in spLV systolic function, which may be of clinical value. On 
      the other hand, when compared to age- and gender-matched controls, the sRV of 
      Senning patients exhibits significantly decreased measurements of longitudinal 
      systolic function.
FAU - Moya, Ana
AU  - Moya A
AD  - Faculty of Biomedical Sciences, KU Leuven, Leuven, Belgium.
FAU - De Meester, Pieter
AU  - De Meester P
AD  - Division of Structural and Congenital Cardiology, University Hospitals Leuven, 
      Leuven, Belgium.
AD  - Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
FAU - Troost, Els
AU  - Troost E
AD  - Division of Structural and Congenital Cardiology, University Hospitals Leuven, 
      Leuven, Belgium.
FAU - Roggen, Leen
AU  - Roggen L
AD  - Division of Structural and Congenital Cardiology, University Hospitals Leuven, 
      Leuven, Belgium.
FAU - Weidemann, Frank
AU  - Weidemann F
AD  - Medical Clinic I, Klinikum Vest, Recklinghausen, Germany.
FAU - Moons, Philip
AU  - Moons P
AD  - Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
FAU - Eyskens, Benedicte
AU  - Eyskens B
AD  - Division of Pediatric Cardiology, University Hospitals Leuven, Leuven, Belgium.
FAU - Claus, Piet
AU  - Claus P
AD  - Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
FAU - Budts, Werner
AU  - Budts W
AD  - Division of Structural and Congenital Cardiology, University Hospitals Leuven, 
      Leuven, Belgium.
AD  - Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
FAU - Van De Bruaene, Alexander
AU  - Van De Bruaene A
AD  - Division of Structural and Congenital Cardiology, University Hospitals Leuven, 
      Leuven, Belgium.
AD  - Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20200615
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
SB  - IM
MH  - *Arterial Switch Operation
MH  - Color
MH  - Cross-Sectional Studies
MH  - Follow-Up Studies
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - *Ventricular Function, Left
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - Transposition of great vessels
OT  - atrial switch procedure
OT  - heart failure
OT  - right ventricular dysfunction
OT  - senning procedure
OT  - systemic right ventricle
EDAT- 2020/06/17 06:00
MHDA- 2021/11/26 06:00
CRDT- 2020/06/17 06:00
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
AID - 10.1080/00015385.2020.1770459 [doi]
PST - ppublish
SO  - Acta Cardiol. 2021 Sep;76(7):689-696. doi: 10.1080/00015385.2020.1770459. Epub 
      2020 Jun 15.