PMID- 32540234
OWN - NLM
STAT- MEDLINE
DCOM- 20200902
LR  - 20200902
IS  - 1524-4733 (Electronic)
IS  - 1098-3015 (Linking)
VI  - 23
IP  - 6
DP  - 2020 Jun
TI  - Acceptability and Validity of the EQ-5D in Patients Living With Dementia.
PG  - 760-767
LID - S1098-3015(20)30153-4 [pii]
LID - 10.1016/j.jval.2020.01.022 [doi]
AB  - OBJECTIVES: To assess the acceptability and validity of the 3 levels of the EQ-5D 
      (EQ-5D-3L) compared with the Quality of Life in Alzheimer's Diseases (QoL-AD) in 
      patients living with dementia. METHODS: The analysis was based on 560 dyads of 
      persons with dementia and their caregivers of the multicenter observational study 
      of dementia care networks in Germany (DemNet-D). Health-related quality of life 
      was assessed by face-to-face interviews using the EQ-5D-3L (self-rating) and the 
      QoL-AD (self- and proxy-rating). The number of missing values, the score ranges 
      (observed vs possible range) and the floor and ceiling effects were used to 
      assess the acceptability. We used one-way analyses of variance and multivariate 
      linear regression models to evaluate the discriminative ability. The convergent 
      validity was assessed using Spearman's correlation coefficient (r(s)) and 
      multivariate regression models. RESULTS: The EQ-5D index had a higher response 
      rate (89% vs 84%) and a comparable floor (>1%) but a higher ceiling effect (18% 
      vs >1%) compared with the QoL-AD. Both measures can significantly differentiate 
      between different stages of general health, instrumental activities of daily 
      living, and depression. The EQ-5D index and the visual analog scale self-rating 
      scores strongly correlated with the QoL-AD self-rating (r(s) = 0.644 and 0.553, 
      respectively) but not with the proxy-rating score (r(s) = 0.314 and r(s) = 0.170, 
      respectively), which was confirmed by multivariate regression analyses. 
      CONCLUSION: The results satisfy acceptability, discriminative ability, and 
      convergent validity for moderately cognitively and functionally impaired patients 
      living with dementia. The EQ-5D-3L performed comparably with the QoL-AD, and 
      could, therefore, be used in economic evaluations in dementia. The differences 
      between self- and proxy-ratings should be evaluated and considered in the 
      interpretation of health-related quality of life scores.
CI  - Copyright (c) 2020 ISPOR-The Professional Society for Health Economics and Outcomes 
      Research. Published by Elsevier Inc. All rights reserved.
FAU - Michalowsky, Bernhard
AU  - Michalowsky B
AD  - German Center for Neurodegenerative Diseases, Rostock/Greifswald site, 
      Greifswald, Germany; Program for Health Economics and Outcome Measures, Hamilton, 
      Ontario, Canada.
FAU - Xie, Feng
AU  - Xie F
AD  - Program for Health Economics and Outcome Measures, Hamilton, Ontario, Canada; 
      Department of Health Research Methods, Evidence and Impact (formerly Clinical 
      Epidemiology and Biostatistics), McMaster University, Hamilton, Ontario, Canada. 
      Electronic address: fengxie@mcmaster.ca.
FAU - Kohlmann, Thomas
AU  - Kohlmann T
AD  - Institute for Community Medicine, Section Methods in Community Medicine, 
      University Medicine Greifswald, Greifswald, Germany.
FAU - Graske, Johannes
AU  - Graske J
AD  - Alice Salomon University of Applied Sciences Berlin, Berlin, Germany.
FAU - Wubbeler, Markus
AU  - Wubbeler M
AD  - University of Applied Sciences-Bochum, Department of Nursing Science, Bochum, 
      Germany.
FAU - Thyrian, Jochen Rene
AU  - Thyrian JR
AD  - German Center for Neurodegenerative Diseases, Rostock/Greifswald site, 
      Greifswald, Germany.
FAU - Hoffmann, Wolfgang
AU  - Hoffmann W
AD  - German Center for Neurodegenerative Diseases, Rostock/Greifswald site, 
      Greifswald, Germany; Institute for Community Medicine, Section Epidemiology of 
      Health Care and Community Health, University Medicine Greifswald, Greifswald, 
      Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20200522
PL  - United States
TA  - Value Health
JT  - Value in health : the journal of the International Society for Pharmacoeconomics 
      and Outcomes Research
JID - 100883818
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*psychology
MH  - Caregivers/*psychology
MH  - Dementia/*psychology
MH  - Depression/epidemiology
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Patient Reported Outcome Measures
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - *Surveys and Questionnaires
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - EQ-5D
OT  - dementia
OT  - patient-reported outcomes
OT  - preference-based measures
OT  - quality of life
OT  - validation
EDAT- 2020/06/17 06:00
MHDA- 2020/09/04 06:00
CRDT- 2020/06/17 06:00
PHST- 2019/09/30 00:00 [received]
PHST- 2019/12/11 00:00 [revised]
PHST- 2020/01/22 00:00 [accepted]
PHST- 2020/06/17 06:00 [entrez]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
AID - S1098-3015(20)30153-4 [pii]
AID - 10.1016/j.jval.2020.01.022 [doi]
PST - ppublish
SO  - Value Health. 2020 Jun;23(6):760-767. doi: 10.1016/j.jval.2020.01.022. Epub 2020 
      May 22.