PMID- 32540546
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20221207
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 258
DP  - 2020 Nov
TI  - Sex-specific associations of blood and urinary manganese levels with glucose 
      levels, insulin resistance and kidney function in US adults: National health and 
      nutrition examination survey 2011-2016.
PG  - 126940
LID - S0045-6535(20)31133-4 [pii]
LID - 10.1016/j.chemosphere.2020.126940 [doi]
AB  - Exposures to heavy metals play a role in the etiopathogenesis of diabetes. 
      Epidemiological studies investigating a potential sex-specific linkage between 
      manganese (Mn) exposures and glucose homeostasis are rare. We comprehensively 
      estimated the associations of blood and urinary Mn levels with fasting plasma 
      glucose (FPG), hemoglobin A1c (HbA1c), homeostasis model assessment for insulin 
      resistance (HOMA-IR), insulin, and estimated glomerular filtration rate (eGFR) 
      among 1417 adults in the US National Health and Nutrition Examination Survey 
      (NHANES) 2011-2016. We further examined the potential heterogeneities by sex and 
      joint-effects of multiple metal exposures by the Bayesian kernel machine 
      regression (BKMR). Among women, we found positive linear relationships between 
      urinary Mn with FPG (P(overall) = 0.003, P(nonlinear) = 0.817) and HbA1c 
      (P(overall) = 0.023, P(nonlinear) = 0.854). Among men, J-shaped relationships 
      were observed between blood Mn with HOMA-IR (P(nonlinear) = 0.042) and insulin 
      (P(nonlinear) = 0.014). For eGFR, positive linear relationships were obserned 
      among women for blood Mn (P(nonlinear) = 0.549) and among both men and women for 
      urinary Mn levels. The joint-effects of urinary Mn with molybdenum (Mo) on FPG 
      and HbA1c, urinary Mn with cadmium (Cd) and cesium (Cs) on eGFR, and blood Mn 
      with Cd and lead (Pb) on eGFR were detected. In summary, blood and urinary Mn 
      levels were independently associated with glucose levels, insulin resistance and 
      kidney function with potential sex-dependent heterogeneities. These findings 
      emphasize the probable role of Mn in the regulation of glucose metabolism and 
      kidney function, and confirm the need for more studies on sex-specific risk of 
      diabetes.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Yang, Jingli
AU  - Yang J
AD  - College of Earth and Environmental Sciences, Department of Epidemiology and 
      Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
FAU - Yang, Aimin
AU  - Yang A
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Prince of Wales Hospital, Hong Kong Special Administrative Region.
FAU - Cheng, Ning
AU  - Cheng N
AD  - Department of Basic Medicine, Lanzhou University, Lanzhou, Gansu, China.
FAU - Huang, Wenya
AU  - Huang W
AD  - College of Earth and Environmental Sciences, Department of Epidemiology and 
      Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
FAU - Huang, Peiyao
AU  - Huang P
AD  - College of Earth and Environmental Sciences, Department of Epidemiology and 
      Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
FAU - Liu, Nian
AU  - Liu N
AD  - College of Earth and Environmental Sciences, Department of Epidemiology and 
      Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
FAU - Bai, Yana
AU  - Bai Y
AD  - College of Earth and Environmental Sciences, Department of Epidemiology and 
      Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China. 
      Electronic address: baiyana@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200530
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 00BH33GNGH (Cadmium)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bayes Theorem
MH  - Blood Glucose/*analysis/metabolism
MH  - Cadmium/urine
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance/physiology
MH  - Kidney Function Tests
MH  - Male
MH  - Manganese/*blood/*urine
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Sex Factors
MH  - United States
MH  - Young Adult
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Glucose
OT  - Insulin resistance
OT  - Kidney function tests
OT  - Manganese
OT  - Metals
COIS- Declaration of competing interest None.
EDAT- 2020/06/17 06:00
MHDA- 2020/10/21 06:00
CRDT- 2020/06/17 06:00
PHST- 2020/01/30 00:00 [received]
PHST- 2020/04/17 00:00 [revised]
PHST- 2020/04/29 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
AID - S0045-6535(20)31133-4 [pii]
AID - 10.1016/j.chemosphere.2020.126940 [doi]
PST - ppublish
SO  - Chemosphere. 2020 Nov;258:126940. doi: 10.1016/j.chemosphere.2020.126940. Epub 
      2020 May 30.