PMID- 32540630
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20231111
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 27
DP  - 2020
TI  - Role of the default mode resting-state network for cognitive functioning in 
      malignant glioma patients following multimodal treatment.
PG  - 102287
LID - S2213-1582(20)30124-8 [pii]
LID - 10.1016/j.nicl.2020.102287 [doi]
LID - 102287
AB  - BACKGROUND: Progressive cognitive decline following multimodal neurooncological 
      treatment is a common observation in patients suffering from malignant glioma. 
      Alterations of the default-mode network (DMN) represent a possible source of 
      impaired neurocognitive functioning and were analyzed in these patients. METHODS: 
      Eighty patients (median age, 51 years) with glioma (WHO grade IV glioblastoma, 
      n = 57; WHO grade III anaplastic astrocytoma, n = 13; WHO grade III anaplastic 
      oligodendroglioma, n = 10) and ECOG performance score 0-1 underwent resting-state 
      functional MRI (rs-fMRI) and neuropsychological testing at a median interval of 
      13 months (range, 1-114 months) after initiation of therapy. For evaluation of 
      structural and metabolic changes after treatment, anatomical MRI and amino acid 
      PET using O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) were simultaneously acquired 
      to rs-fMRI on a hybrid MR/PET scanner. A cohort of 80 healthy subjects matched 
      for gender, age, and educational status served as controls. RESULTS: The 
      connectivity pattern within the DMN (12 nodes) of the glioma patients differed 
      significantly from that of the healthy subjects but did not depend on age, tumor 
      grade, time since treatment initiation, presence of residual/recurrent tumor, 
      number of chemotherapy cycles received, or anticonvulsive medication. Small 
      changes in the connectivity pattern were observed in patients who had more than 
      one series of radiotherapy. In contrast, structural tissue changes located at or 
      near the tumor site (including resection cavities, white matter lesions, edema, 
      and tumor tissue) had a strong negative impact on the functional connectivity of 
      the adjacent DMN nodes, resulting in a marked dependence of the connectivity 
      pattern on tumor location. In the majority of neurocognitive domains, glioma 
      patients performed significantly worse than healthy subjects. Correlation 
      analysis revealed that reduced connectivity in the left temporal and parietal DMN 
      nodes was associated with low performance in language processing and verbal 
      working memory. Furthermore, connectivity of the left parietal DMN node also 
      correlated with processing speed, executive function, and verbal as well as 
      visual working memory. Overall DMN connectivity loss and cognitive decline were 
      less pronounced in patients with higher education. CONCLUSION: Personalized 
      treatment strategies for malignant glioma patients should consider the left 
      parietal and temporal DMN nodes as vulnerable regions concerning neurocognitive 
      outcome.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Kocher, Martin
AU  - Kocher M
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Stereotaxy and 
      Functional Neurosurgery, Center for Neurosurgery, Faculty of Medicine and 
      University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Center of 
      Integrated Oncology (CIO), Universities of Aachen, Bonn, Cologne and Duesseldorf, 
      Kerpener Str. 62, 50937 Cologne, Germany. Electronic address: 
      martin.kocher@uk-koeln.de.
FAU - Jockwitz, Christiane
AU  - Jockwitz C
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Psychiatry, 
      Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074 
      Aachen, Germany.
FAU - Caspers, Svenja
AU  - Caspers S
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Juelich-Aachen Research Alliance 
      (JARA)-Section JARA-Brain, Wilhelm-Johnen-Str., 52428 Juelich, Germany; Institute 
      for Anatomy I, Medical Faculty, Heinrich Heine University Duesseldorf, 
      Universitaetsstr. 1, 40225 Duesseldorf, Germany.
FAU - Schreiber, Jan
AU  - Schreiber J
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany.
FAU - Farrher, Ezequiel
AU  - Farrher E
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany.
FAU - Stoffels, Gabriele
AU  - Stoffels G
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany.
FAU - Filss, Christian
AU  - Filss C
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany.
FAU - Lohmann, Philipp
AU  - Lohmann P
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Stereotaxy and 
      Functional Neurosurgery, Center for Neurosurgery, Faculty of Medicine and 
      University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
FAU - Tscherpel, Caroline
AU  - Tscherpel C
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Neurology, Faculty of 
      Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 
      62, 50937 Cologne, Germany; Center of Integrated Oncology (CIO), Universities of 
      Aachen, Bonn, Cologne and Duesseldorf, Kerpener Str. 62, 50937 Cologne, Germany.
FAU - Ruge, Maximilian I
AU  - Ruge MI
AD  - Department of Stereotaxy and Functional Neurosurgery, Center for Neurosurgery, 
      Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937 
      Cologne, Germany; Center of Integrated Oncology (CIO), Universities of Aachen, 
      Bonn, Cologne and Duesseldorf, Kerpener Str. 62, 50937 Cologne, Germany.
FAU - Fink, Gereon R
AU  - Fink GR
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Neurology, Faculty of 
      Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 
      62, 50937 Cologne, Germany.
FAU - Shah, Nadim J
AU  - Shah NJ
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Institute of Neuroscience and 
      Medicine 11, JARA, Research Center Juelich, Wilhelm-Johnen-Str., 52428 Juelich, 
      Germany; Juelich-Aachen Research Alliance (JARA)-Section JARA-Brain, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Neurology, University 
      Hospital Aachen, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.
FAU - Galldiks, Norbert
AU  - Galldiks N
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Neurology, Faculty of 
      Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 
      62, 50937 Cologne, Germany; Center of Integrated Oncology (CIO), Universities of 
      Aachen, Bonn, Cologne and Duesseldorf, Kerpener Str. 62, 50937 Cologne, Germany.
FAU - Langen, Karl-Josef
AU  - Langen KJ
AD  - Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, 
      Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Nuclear Medicine, 
      University Hospital Aachen, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200526
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/pathology/physiopathology
MH  - Cognition/*physiology
MH  - Cognitive Dysfunction/pathology/*physiopathology
MH  - Female
MH  - Glioma/*pathology/*physiopathology
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Middle Aged
MH  - Nerve Net/pathology/physiopathology
MH  - Neural Pathways/*pathology/physiopathology
MH  - Neuropsychological Tests
MH  - Rest/physiology
PMC - PMC7298724
OTO - NOTNLM
OT  - Functional magnetic resonance imaging
OT  - Malignant glioma
OT  - Neurocognitive testing
OT  - Positron emission tomography
OT  - Resting-state networks
EDAT- 2020/06/17 06:00
MHDA- 2021/03/30 06:00
PMCR- 2020/05/26
CRDT- 2020/06/17 06:00
PHST- 2020/01/10 00:00 [received]
PHST- 2020/03/31 00:00 [revised]
PHST- 2020/04/27 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
PHST- 2020/05/26 00:00 [pmc-release]
AID - S2213-1582(20)30124-8 [pii]
AID - 102287 [pii]
AID - 10.1016/j.nicl.2020.102287 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2020;27:102287. doi: 10.1016/j.nicl.2020.102287. Epub 2020 May 
      26.