PMID- 32540641
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 80
DP  - 2020 Aug
TI  - Comparison of the neurocognitive outcomes in term infants treated with 
      levetiracetam and phenobarbital monotherapy for neonatal clinical seizures.
PG  - 71-74
LID - S1059-1311(20)30168-0 [pii]
LID - 10.1016/j.seizure.2020.06.006 [doi]
AB  - PURPOSE: This study aims to compare the neurocognitive outcome in term infants 
      who were treated using phenobarbital (PB) and levetiracetam (LEV) monotherapy for 
      neonatal clinical seizures. METHODS: Term infants who were treated using PB or 
      LEV monotherapy as the first-line anti-epileptic treatment for neonatal clinical 
      seizures and followed-up in a pediatric neurology outpatient clinic were enrolled 
      in this study. Neurodevelopmental outcome assessments were carried out using the 
      Bayley Scales of Infant Development, third edition (BSID-III), including 
      cognitive, receptive language, expressive language, fine motor and gross motor 
      subscales. RESULTS: The study group consisted of 62 infants who received 
      monotherapy with PB monotherapy (n = 22) and LEV (n = 40). The mean duration of 
      monotherapy treatment was 8 +/- 6 months. There was no statistically significant 
      difference between PB and LEV monotherapy groups concerning each outcome 
      parameter on the BSID-III. There was also no statistically significant difference 
      between PB and LEV monotherapy subgroups excluding the infants with 
      neurodevelopmental impairment with a BSID-III scale score<7 or a composite 
      score<85. CONCLUSION: Our findings suggest that both LEV and PB therapy can be 
      equally safe as monotherapy for neonatal clinical seizures for the 
      neurodevelopmental outcome assessment with BSID-III.
CI  - Copyright (c) 2020 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Arican, Pinar
AU  - Arican P
AD  - Department of Pediatric Neurology, Kahramanmaras Necip Fazil Hospital, 
      Kahramanmaras, Turkey.
FAU - Olgac Dundar, Nihal
AU  - Olgac Dundar N
AD  - Department of Pediatric Neurology, Izmir Katip Celebi University, Izmir, Turkey. 
      Electronic address: nodundar@gmail.com.
FAU - Mete Atasever, Neslihan
AU  - Mete Atasever N
AD  - Department of Pediatric Neurology, Izmir Tepecik Education and Research Hospital, 
      Izmir, Turkey.
FAU - Akkaya Inal, Mine
AU  - Akkaya Inal M
AD  - Department of Pediatric Neurology, Izmir Tepecik Education and Research Hospital, 
      Izmir, Turkey.
FAU - Gencpinar, Pinar
AU  - Gencpinar P
AD  - Department of Pediatric Neurology, Izmir Katip Celebi University, Izmir, Turkey.
FAU - Cavusoglu, Dilek
AU  - Cavusoglu D
AD  - Department of Pediatric Neurology, Afyon Kocatepe University, Afyon, Turkey.
FAU - Akbay, Sinem
AU  - Akbay S
AD  - Neonatology Department, Manisa City Hospital, Izmir, Turkey.
FAU - Tekgul, Hasan
AU  - Tekgul H
AD  - Department of Pediatric Neurology, Ege University, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20200605
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
RN  - 44YRR34555 (Levetiracetam)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Anticonvulsants/therapeutic use
MH  - Child
MH  - *Epilepsy/drug therapy
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Levetiracetam/therapeutic use
MH  - *Phenobarbital/therapeutic use
MH  - Seizures/drug therapy
OTO - NOTNLM
OT  - Infant
OT  - Monotherapy
OT  - Neonatal
OT  - Neurodevelopment
OT  - Seizure
COIS- Declaration of Competing Interest The authors declare no potential conflicts of 
      interest regarding this research, authorship, and/or publication of this article.
EDAT- 2020/06/17 06:00
MHDA- 2021/07/29 06:00
CRDT- 2020/06/17 06:00
PHST- 2020/01/01 00:00 [received]
PHST- 2020/06/01 00:00 [revised]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
AID - S1059-1311(20)30168-0 [pii]
AID - 10.1016/j.seizure.2020.06.006 [doi]
PST - ppublish
SO  - Seizure. 2020 Aug;80:71-74. doi: 10.1016/j.seizure.2020.06.006. Epub 2020 Jun 5.