PMID- 32541652
OWN - NLM
STAT- MEDLINE
DCOM- 20210330
LR  - 20220422
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jun 15
TI  - Insights to the neural response to food cues in class III compared with class I 
      and II obese adults using a sample of endometrial cancer survivors seeking weight 
      loss.
PG  - 21
LID - 10.1038/s41387-020-0124-7 [doi]
LID - 21
AB  - BACKGROUND: The rates of severe or Class III obesity (BMI >/= 40.0 kg/m(2)) and 
      endometrial cancer (EC) incidence and mortality have been increasing 
      significantly in the United States. Adults with severe obesity are more likely to 
      die and women with severe obesity have a higher risk of EC development and 
      mortality than those with Class I/II obesity (BMI: 30-<40 kg/m(2)). However, no 
      prior studies have evaluated the neural response to food cues by obesity 
      severity/class in adults with or without cancer. METHODS: We conducted a 
      functional magnetic resonance imaging visual food cue task in 85 obese Stage I EC 
      survivors who were seeking weight loss in a lifestyle intervention at baseline. 
      We evaluated the neural response to high-calorie vs. non-food images after an 
      overnight fast (fasted state) and after eating a standardized meal (fed state), 
      and grouped patients by obesity class (Class I/II: n = 38; Class III: n = 47). 
      RESULTS: In the fasted state, we found increased activation in several regions 
      including the dorsolateral prefrontal cortex (DLPFC) in Class III and Class I/II 
      patients (whole brain cluster corrected (WBCC), p < 0.05), which was 
      significantly higher in Class III vs. Class I/II (p < 0.05). We found decreased 
      activation in the insula in the fasted state, which was significantly lower in 
      Class I/II vs. Class III (p = 0.03). In the fed state, we found increased 
      activation in the DLPFC in Class III and Class I/II (WBCC, p < 0.05). The 
      increased activation in cognitive control/inhibition regions (DLPFC) is 
      consistent with the summative literature; however, the decreased activation in 
      taste information processing regions (insula) was unexpected. CONCLUSIONS: Our 
      results provide novel insights on food cue response between different classes of 
      obesity and highlight the importance of targeting the DLPFC in weight loss 
      interventions, particularly in severely obese patients. Additional studies 
      examining food-related neural circuitry between different classes of obesity are 
      needed.
FAU - Nock, Nora L
AU  - Nock NL
AUID- ORCID: 0000-0002-6476-6692
AD  - Departments of Population and Quantitative Health Sciences, Case Western Reserve 
      University, Cleveland, OH, USA. nln@case.edu.
AD  - Case Comprehensive Cancer Center, Cleveland, OH, USA. nln@case.edu.
FAU - Jiang, Huangqi
AU  - Jiang H
AD  - Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
FAU - Borato, Lauren
AU  - Borato L
AD  - Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
FAU - Alberts, Jay
AU  - Alberts J
AD  - Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.
FAU - Dimitropoulos, Anastasia
AU  - Dimitropoulos A
AD  - Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
LA  - eng
GR  - R01 CA175100/CA/NCI NIH HHS/United States
GR  - UL1 RR024989/RR/NCRR NIH HHS/United States
GR  - UL1 TR002548/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200615
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
SB  - IM
MH  - Aged
MH  - Brain/*metabolism
MH  - Cancer Survivors/*psychology
MH  - Cues
MH  - Endometrial Neoplasms/epidemiology/*psychology
MH  - Energy Intake
MH  - *Feeding Behavior
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Meals
MH  - Middle Aged
MH  - Obesity/classification/epidemiology/*psychology
MH  - Obesity, Morbid/epidemiology/psychology
MH  - Prefrontal Cortex/metabolism
MH  - Reward
MH  - Weight Loss
PMC - PMC7296040
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/06/17 06:00
MHDA- 2021/03/31 06:00
PMCR- 2020/06/15
CRDT- 2020/06/17 06:00
PHST- 2020/02/17 00:00 [received]
PHST- 2020/05/28 00:00 [accepted]
PHST- 2020/05/26 00:00 [revised]
PHST- 2020/06/17 06:00 [entrez]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/03/31 06:00 [medline]
PHST- 2020/06/15 00:00 [pmc-release]
AID - 10.1038/s41387-020-0124-7 [pii]
AID - 124 [pii]
AID - 10.1038/s41387-020-0124-7 [doi]
PST - epublish
SO  - Nutr Diabetes. 2020 Jun 15;10(1):21. doi: 10.1038/s41387-020-0124-7.