PMID- 32542011
OWN - NLM
STAT- MEDLINE
DCOM- 20200825
LR  - 20200825
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 6
DP  - 2020
TI  - Non-ST elevation acute coronary syndrome in patients aged 80 years or older in 
      Vietnam: An observational study.
PG  - e0233272
LID - 10.1371/journal.pone.0233272 [doi]
LID - e0233272
AB  - BACKGROUND: There is limited evidence of non-ST elevation acute coronary syndrome 
      (NSTE-ACS) in patients aged 80 or older in Vietnam. AIM: To describe the clinical 
      characteristics of patients aged>/=80 with NSTE-ACS in Vietnam, and to examine the 
      effect of percutaneous coronary intervention (PCI) on adverse outcomes. METHODS: 
      Consecutive patients aged >/=80 with a diagnosis of NSTE-ACS admitted to two 
      tertiary hospitals in Vietnam from 12/2018 to 06/2019 were recruited. The major 
      outcomes were: (1) the composite of all-cause mortality, recurrent myocardial 
      infarction and stroke, (2) re-admission rate during 3 months. Cox 
      proportional-hazards regressions were conducted to examine the impact of PCI on 
      the study outcomes, with results presented as hazard ratios (HR) and 95% 
      confidence intervals (CI). RESULTS: There were 120 participants, mean age 84.8 +/- 
      3.8, 50% were female. Angiography and PCI were performed in 42 participants 
      (35.0%). Most of the participants had multimorbidity and multiple coronary vessel 
      disease. Compared to participants who did not receive PCI, participants who 
      received PCI had significantly lower rates of adverse events during 
      hospitalisation and during 3 months of follow up. Cox proportional hazards models 
      adjusted to age and GRACE score show that PCI was significantly associated with 
      reduced the composite outcome of all-cause mortality, recurrent myocardial 
      infarction and stroke during 3 months follow-up (adjusted HR 0.32, 95%CI 
      0.12-0.86). PCI was also associated with reduced re-admission. CONCLUSIONS: The 
      rate of PCI was low in the very elderly patients with NSTE-ACS in this study, 
      although PCI was significantly associated with reduced adverse outcomes.
FAU - Nguyen, Tan Van
AU  - Nguyen TV
AD  - Department of Geriatrics & Gerontology, University of Medicine and Pharmacy in Ho 
      Chi Minh City, Ho Chi Minh City, Vietnam.
AD  - Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, 
      Vietnam.
FAU - Bui, Khai Xuan
AU  - Bui KX
AD  - Department of Geriatrics & Gerontology, University of Medicine and Pharmacy in Ho 
      Chi Minh City, Ho Chi Minh City, Vietnam.
FAU - Tran, Khuong Dang
AU  - Tran KD
AD  - Department of Geriatrics & Gerontology, University of Medicine and Pharmacy in Ho 
      Chi Minh City, Ho Chi Minh City, Vietnam.
FAU - Le, Duong
AU  - Le D
AD  - Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, 
      Vietnam.
FAU - Nguyen, Tu Ngoc
AU  - Nguyen TN
AUID- ORCID: 0000-0002-8836-8920
AD  - Westmead Applied Research Centre, Faculty of Medicine and Health, The University 
      of Sydney, Sydney, New South Wales, Australia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200615
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Acute Coronary Syndrome/diagnosis/*epidemiology/mortality
MH  - Aged, 80 and over
MH  - Coronary Angiography
MH  - Coronary Artery Disease/complications
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Myocardial Infarction/mortality
MH  - Non-ST Elevated Myocardial Infarction/diagnosis/*epidemiology/mortality
MH  - Percutaneous Coronary Intervention/*adverse effects/methods
MH  - Proportional Hazards Models
MH  - Stroke/complications
MH  - Treatment Outcome
MH  - Vietnam/epidemiology
PMC - PMC7295222
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/06/17 06:00
MHDA- 2020/08/26 06:00
PMCR- 2020/06/15
CRDT- 2020/06/17 06:00
PHST- 2019/11/25 00:00 [received]
PHST- 2020/05/01 00:00 [accepted]
PHST- 2020/06/17 06:00 [entrez]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2020/08/26 06:00 [medline]
PHST- 2020/06/15 00:00 [pmc-release]
AID - PONE-D-19-32737 [pii]
AID - 10.1371/journal.pone.0233272 [doi]
PST - epublish
SO  - PLoS One. 2020 Jun 15;15(6):e0233272. doi: 10.1371/journal.pone.0233272. 
      eCollection 2020.