PMID- 32542408
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1432-0878 (Electronic)
IS  - 0302-766X (Print)
IS  - 0302-766X (Linking)
VI  - 381
IP  - 3
DP  - 2020 Sep
TI  - Aquaporin 1 affects pregnancy outcome and regulates aquaporin 8 and 9 expressions 
      in the placenta.
PG  - 543-554
LID - 10.1007/s00441-020-03221-w [doi]
AB  - To explore the effects of aquaporin (AQP) 1 on pregnancy outcome and the 
      association between expression of AQP1 and other AQPs in the placenta and foetal 
      membranes, the rate of copulatory plugs and pregnancy, amniotic fluid (AF) 
      volume, osmolality and composition were determined in AQP1-knockout (AQP1(-/-)) 
      mice at different gestational days (GD). The expression and location of AQP1 and 
      other AQPs in the placenta and foetal membranes of AQP1(-/-) mice, AQP1-siRNA 
      transfected WISH cells and oligohydramnios patients were also detected. Compared 
      to control mice, AQP1(-/-) mice exhibited reduced copulation plug and successful 
      pregnancy rates, but these effects were accompanied by a larger AF volume and 
      lower AF osmolality at late gestation. AQP9 expression was significantly 
      decreased in the placenta and foetal membranes of AQP1(-/-) mice, while AQP8 
      level was elevated in the foetal membranes of AQP1(-/-) mice. Moreover, AQP9 
      expression was suppressed in WISH cells after AQP1 downregulation. Furthermore, 
      AQP9 expression was associated with AQP1 level in the placenta and foetal 
      membranes in oligohydramnios. AQP1 may play a critical role in regulating 
      pregnancy outcome and maternal-foetal fluid homeostasis. Changes in AQP1 
      expression may lead to compensatory alterations in AQP8 and AQP9 expression in 
      the placenta.
FAU - Luo, Hui
AU  - Luo H
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, No. 109 Xueyuan Xi Road Wenzhou, Zhejiang, 325027, 
      China.
FAU - Liu, Yi
AU  - Liu Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, No. 109 Xueyuan Xi Road Wenzhou, Zhejiang, 325027, 
      China.
FAU - Song, Yizuo
AU  - Song Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, No. 109 Xueyuan Xi Road Wenzhou, Zhejiang, 325027, 
      China.
FAU - Hua, Ying
AU  - Hua Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, No. 109 Xueyuan Xi Road Wenzhou, Zhejiang, 325027, 
      China.
FAU - Zhu, Xueqiong
AU  - Zhu X
AUID- ORCID: 0000-0002-8389-928X
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of 
      Wenzhou Medical University, No. 109 Xueyuan Xi Road Wenzhou, Zhejiang, 325027, 
      China. zjwzzxq@163.com.
LA  - eng
GR  - Y20160124/Project of Wenzhou Science and Technology/
GR  - 81601319/National Nature Science Fund of China/
PT  - Journal Article
DEP - 20200615
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (AQP9 protein, human)
RN  - 0 (Aquaporins)
RN  - 0 (aquaporin 8)
RN  - 146410-94-8 (Aquaporin 1)
SB  - IM
MH  - Animals
MH  - Aquaporin 1/*metabolism
MH  - Aquaporins/*metabolism
MH  - Female
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Placenta/*metabolism
MH  - Pregnancy
PMC - PMC7431401
OTO - NOTNLM
OT  - Amniotic fluid
OT  - Aquaporin
OT  - Foetal membrane
OT  - Placenta
OT  - Pregnancy outcome
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/06/17 06:00
MHDA- 2021/05/29 06:00
PMCR- 2020/06/15
CRDT- 2020/06/17 06:00
PHST- 2020/02/05 00:00 [received]
PHST- 2020/04/24 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
PHST- 2020/06/15 00:00 [pmc-release]
AID - 10.1007/s00441-020-03221-w [pii]
AID - 3221 [pii]
AID - 10.1007/s00441-020-03221-w [doi]
PST - ppublish
SO  - Cell Tissue Res. 2020 Sep;381(3):543-554. doi: 10.1007/s00441-020-03221-w. Epub 
      2020 Jun 15.