PMID- 32542857
OWN - NLM
STAT- MEDLINE
DCOM- 20210513
LR  - 20210513
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 35
IP  - 11
DP  - 2020 Nov
TI  - Effect of prophylactic closure on adverse events after colorectal endoscopic 
      submucosal dissection: A meta-analysis.
PG  - 1869-1877
LID - 10.1111/jgh.15148 [doi]
AB  - BACKGROUND AND AIM: Endoscopic submucosal dissection (ESD) has a high en bloc 
      resection rate and is widely performed for large colorectal lesions. However, 
      colorectal ESD is associated with a high frequency of adverse events (AEs), and 
      the efficacy of prophylactic endoscopic closure after ESD for preventing AEs is 
      still controversial. This meta-analysis was conducted to assess the efficacy of 
      closure on AEs following colorectal ESD. METHODS: We searched PubMed, Embase, and 
      the Cochrane Library for eligible studies. The chi-square-based Q statistics and 
      the I(2) test were used to test for heterogeneity. Pooling was conducted using a 
      fixed or random effects model. RESULTS: We identified eight eligible studies that 
      compared the effects of closure vs non-closure with respect to delayed bleeding, 
      delayed perforation, and post-ESD coagulation syndrome. Compared with non-closure 
      (5.2%), closure was associated with a lower incidence (0.9%) of delayed bleeding 
      (pooled odd ratios [ORs]:0.19, 95% CI: 0.08-0.49) following ESD. The pooled ORs 
      showed no significant differences in incidence of delayed perforation (pooled OR: 
      0.22; 95% CI: 0.05-1.03) or post-ESD coagulation syndrome (pooled OR:0.75; 95% 
      CI: 0.26-2.18) between the closure and non-closure groups. CONCLUSION: 
      Prophylactic endoscopic closure may reduce the incidence of delayed bleeding 
      following ESD of colorectal lesions. Future studies are needed to further 
      illuminate risk factors and stratify high risk subjects for a cost-effective 
      preventive strategy.
CI  - (c) 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & 
      Sons Australia, Ltd.
FAU - Liu, Mingqing
AU  - Liu M
AUID- ORCID: 0000-0001-6633-1580
AD  - Department of Gastroenterology, First Hospital of Jilin University, ChangChun, 
      China.
FAU - Zhang, Yangyu
AU  - Zhang Y
AUID- ORCID: 0000-0001-7579-1888
AD  - Division of Clinical Research, First Hospital of Jilin University, Changchun, 
      Jilin Province, China.
FAU - Wang, Yueqi
AU  - Wang Y
AUID- ORCID: 0000-0003-4074-260X
AD  - Division of Clinical Research, First Hospital of Jilin University, Changchun, 
      Jilin Province, China.
FAU - Zhu, He
AU  - Zhu H
AUID- ORCID: 0000-0002-2310-4174
AD  - Department of Gastroenterology, First Hospital of Jilin University, ChangChun, 
      China.
FAU - Xu, Hong
AU  - Xu H
AUID- ORCID: 0000-0003-1228-3645
AD  - Department of Gastroenterology, First Hospital of Jilin University, ChangChun, 
      China.
LA  - eng
GR  - 2017F005/Department of Finance of Jilin Province/
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20200705
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Coagulation Disorders/etiology/prevention & control
MH  - Colorectal Neoplasms/*surgery
MH  - Endoscopic Mucosal Resection/*adverse effects/*methods
MH  - Endoscopy, Gastrointestinal/*methods
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Intestinal Mucosa/*surgery
MH  - Intestinal Perforation/etiology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Postoperative Hemorrhage/*etiology/*prevention & control
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Wound Closure Techniques
OTO - NOTNLM
OT  - bleeding
OT  - endoscopic submucosal dissection
OT  - meta-analysis
OT  - prophylactic endoscopic closure
EDAT- 2020/06/17 06:00
MHDA- 2021/05/14 06:00
CRDT- 2020/06/17 06:00
PHST- 2020/03/13 00:00 [received]
PHST- 2020/06/08 00:00 [revised]
PHST- 2020/06/11 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/05/14 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
AID - 10.1111/jgh.15148 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2020 Nov;35(11):1869-1877. doi: 10.1111/jgh.15148. Epub 
      2020 Jul 5.