PMID- 32542909
OWN - NLM
STAT- MEDLINE
DCOM- 20210921
LR  - 20210921
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 8
IP  - 3
DP  - 2020 Sep
TI  - Prevalence of IgE-mediated sensitization in patients with suspected food allergic 
      reactions in Jordan.
PG  - 384-392
LID - 10.1002/iid3.320 [doi]
AB  - BACKGROUND: Despite the recognition of food allergies as a significant cause of 
      morbidity and a growing public health burden worldwide, there are no 
      epidemiological studies addressing food sensitization and allergy in Jordan. 
      OBJECTIVE: To conduct an epidemiological study that retrospectively analyzes 
      sensitization data from 3463 patients with suspected immunoglobulin E 
      (IgE)-mediated food allergic reactions who performed specific IgE tests in our 
      laboratories in Jordan. METHODS: Specific IgE (s-IgE) tests were analyzed for 
      patients who performed enzyme allegro-sorbent testing based on either 
      self-reported food allergy or upon physician's request. RESULTS: 2.3% of the 
      analyzed samples were cross-reactive to carbohydrate determinants. A quarter of 
      the patients were sensitized to one or more food allergens, with males having 
      higher odds of being s-IgE positive. Furthermore, a higher prevalence of 
      sensitization was seen in infants and children compared with adults. s-IgE was 
      most frequently found against cow milk (11.2%), pistachio (4.9%), soybean (4.6%), 
      cherry (4.4%), and orange (4.4%). Interestingly, the s-IgE class distribution 
      profile of pistachio differed from the rest of the top hits being skewed away 
      from the weak class 1 leaning more towards higher IgE classes. Food allergen 
      sensitization was age group-dependent: milk, tree nuts, and eggs were the main 
      food groups causing sensitization in infants, while it was fruits followed by 
      milk in children and adults. CONCLUSIONS: Our work represents the first 
      epidemiological study addressing food sensitization in Jordan. This study lays a 
      solid foundation for future studies that can help better guide food allergy 
      diagnosis, patient dietary modifications, and food elimination plans, as well as 
      assist decision-makers in the region to develop national strategies for an 
      efficient and sustainable healthcare system.
CI  - (c) 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Abu-Dayyeh, Issa
AU  - Abu-Dayyeh I
AUID- ORCID: 0000-0003-0224-2292
AD  - Biolab Diagnostic Laboratories, Amman, Jordan.
AD  - Department of Basic Research, Cell Therapy Center, University of Jordan, Amman, 
      Jordan.
FAU - Abu-Kwaik, Jumana
AU  - Abu-Kwaik J
AD  - Biolab Diagnostic Laboratories, Amman, Jordan.
FAU - Weimann, Alf
AU  - Weimann A
AD  - Euroimmun AG, Lubeck, Germany.
FAU - Abdelnour, Amid
AU  - Abdelnour A
AD  - Biolab Diagnostic Laboratories, Amman, Jordan.
LA  - eng
PT  - Journal Article
DEP - 20200615
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Female
MH  - Flour
MH  - *Food Hypersensitivity
MH  - Humans
MH  - Immunoglobulin E
MH  - Jordan
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
MH  - Triticum
PMC - PMC7416048
OTO - NOTNLM
OT  - Jordan
OT  - epidemiological study
OT  - food allergy
OT  - food sensitization
OT  - specific IgE test
EDAT- 2020/06/17 06:00
MHDA- 2021/09/22 06:00
PMCR- 2020/06/15
CRDT- 2020/06/17 06:00
PHST- 2020/04/08 00:00 [received]
PHST- 2020/05/14 00:00 [revised]
PHST- 2020/06/03 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/09/22 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
PHST- 2020/06/15 00:00 [pmc-release]
AID - IID3320 [pii]
AID - 10.1002/iid3.320 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2020 Sep;8(3):384-392. doi: 10.1002/iid3.320. Epub 2020 Jun 
      15.