PMID- 32542951
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20201231
IS  - 1520-6394 (Electronic)
IS  - 1091-4269 (Linking)
VI  - 37
IP  - 9
DP  - 2020 Sep
TI  - Cross-lagged analyses of the bidirectional relationship between depression and 
      markers of chronic heart failure.
PG  - 898-907
LID - 10.1002/da.23041 [doi]
AB  - BACKGROUND: Depression is common in patients with chronic heart failure (CHF) and 
      is a predictor of rehospitalization and mortality. However, the complex 
      bidirectional relationships between these two conditions are barely understood. 
      We investigated the course of depression and markers of CHF (New York Heart 
      Association [NYHA] functional class, N-terminal-prohormone B-type natriuretic 
      peptide [NT-proBNP], and left ventricular ejection fraction [LVEF]) in a 
      longitudinal study over a period of 2 years, using three assessment points. 
      METHODS: Data of n = 446 patients with documented CHF were analyzed using 
      structural equation modeling. Specifically, a Bayesian cross-lagged structural 
      equation model was applied. RESULTS: Our study revealed that an aggravation of 
      depression predicted an increase in NYHA functional class (significant 
      cross-lagged effect gamma(h)  = 0.103, 95% confidence interval [CI] [0.017; 0.194]), 
      whereas an increase in NYHA functional class did not predict an aggravation of 
      depression (gamma(d)  = 0.002 95% CI [-0.057; 0.194]). This association was found 
      only for NYHA functional class and depression-not for NT-proBNP and LVEF. 
      CONCLUSIONS: Experiencing depression and associated symptoms, such as lack of 
      energy and fatigue, may lead to a further decrease of functional capacity, and 
      consequently to a higher NYHA functional class in CHF patients. As NYHA 
      functional class is associated with higher mortality, this may be a critical 
      development for affected patients. Further studies are required to investigate 
      whether or not this association could be an essential key that explains the 
      pathway from depression to increased mortality in heart failure patients.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Lossnitzer, Nicole
AU  - Lossnitzer N
AD  - Department of Psychosomatic and General Internal Medicine, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Feisst, Manuel
AU  - Feisst M
AUID- ORCID: 0000-0002-5016-9731
AD  - Institute of Medical Biometry and Informatics, University of Heidelberg, 
      Heidelberg, Germany.
FAU - Wild, Beate
AU  - Wild B
AD  - Department of Psychosomatic and General Internal Medicine, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Katus, Hugo A
AU  - Katus HA
AD  - Department of Cardiology, Angiology and Pulmonology, University of Heidelberg, 
      Heidelberg, Germany.
FAU - Schultz, Jobst-Hendrik
AU  - Schultz JH
AD  - Department of Psychosomatic and General Internal Medicine, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Frankenstein, Lutz
AU  - Frankenstein L
AD  - Department of Cardiology, Angiology and Pulmonology, University of Heidelberg, 
      Heidelberg, Germany.
FAU - Stock, Christian
AU  - Stock C
AD  - Institute of Medical Biometry and Informatics, University of Heidelberg, 
      Heidelberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200616
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
RN  - 0 (Biomarkers)
SB  - IM
MH  - Bayes Theorem
MH  - Biomarkers
MH  - *Depression/epidemiology
MH  - *Heart Failure/epidemiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - NT-proBNP
OT  - NYHA functional class
OT  - bidirectional relationships
OT  - depression
OT  - left ventricular ejection fraction
OT  - markers of chronic heart failure
EDAT- 2020/06/17 06:00
MHDA- 2021/01/01 06:00
CRDT- 2020/06/17 06:00
PHST- 2019/12/12 00:00 [received]
PHST- 2020/04/06 00:00 [revised]
PHST- 2020/05/01 00:00 [accepted]
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
AID - 10.1002/da.23041 [doi]
PST - ppublish
SO  - Depress Anxiety. 2020 Sep;37(9):898-907. doi: 10.1002/da.23041. Epub 2020 Jun 16.