PMID- 32543953
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 17
IP  - 9
DP  - 2020 Sep
TI  - Research Progress in Bioinspired Drug Delivery Systems.
PG  - 1269-1288
LID - 10.1080/17425247.2020.1783235 [doi]
AB  - INTRODUCTION: To tackle challenges associated with traditional drug carriers, 
      investigators have explored cells, cellular membrane, and macromolecular 
      components including proteins and exosomes for the fabrication of delivery 
      vehicles, owing to their excellent biocompatibility, lower toxicity, lower 
      immunogenicity and similarities with the host. Biomacromolecule- and biomimetic 
      nanoparticle (NP)-based drug/gene carriers are drawing immense attention, and 
      biomimetic drug delivery systems (BDDSs) have been conceived and constructed. 
      AREAS COVERED: This review focuses on BDDS based on mammalian cells, including 
      blood cells, cancer cells, adult stem cells, endogenous proteins, pathogens and 
      extracellular vesicles (EVs). EXPERT OPINION: Compared with traditional drug 
      delivery systems (DDSs), BDDSs are based on biological nanocarriers, exhibiting 
      superior biocompatibility, fewer side effects, natural targeting, and diverse 
      modifications. In addition to directly employing natural biomaterials such as 
      cells, proteins, pathogens and EVs as carriers, BDDSs offer these advantages by 
      mimicking the structure of natural nanocarriers through bioengineering 
      technologies. Furthermore, BDDSs demonstrate fewer limitations and irregularities 
      than natural materials and can overcome several shortcomings associated with 
      natural carriers. Although research remains ongoing to resolve these limitations, 
      it is anticipated that BDDSs possess the potential to overcome challenges 
      associated with traditional DDS, with a promising future in the treatment of 
      human diseases.
FAU - Tong, Qirong
AU  - Tong Q
AD  - Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of 
      Education), School of Pharmaceutical Sciences, Shandong University , Jinan, PR 
      China.
FAU - Qiu, Na
AU  - Qiu N
AD  - Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of 
      Education), School of Pharmaceutical Sciences, Shandong University , Jinan, PR 
      China.
FAU - Ji, Jianbo
AU  - Ji J
AD  - Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of 
      Education), School of Pharmaceutical Sciences, Shandong University , Jinan, PR 
      China.
FAU - Ye, Lei
AU  - Ye L
AD  - Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of 
      Education), School of Pharmaceutical Sciences, Shandong University , Jinan, PR 
      China.
FAU - Zhai, Guangxi
AU  - Zhai G
AD  - Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of 
      Education), School of Pharmaceutical Sciences, Shandong University , Jinan, PR 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200625
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Carriers)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/metabolism
MH  - Cell Membrane/metabolism
MH  - Drug Carriers/*chemistry
MH  - *Drug Delivery Systems
MH  - Extracellular Vesicles/metabolism
MH  - Humans
MH  - *Nanoparticles
MH  - Proteins/metabolism
OTO - NOTNLM
OT  - Biomimetic drug delivery systems
OT  - cell membrane
OT  - endogenous proteins
OT  - exosomes
OT  - pathogens
EDAT- 2020/06/17 06:00
MHDA- 2021/02/02 06:00
CRDT- 2020/06/17 06:00
PHST- 2020/06/17 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/06/17 06:00 [entrez]
AID - 10.1080/17425247.2020.1783235 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2020 Sep;17(9):1269-1288. doi: 
      10.1080/17425247.2020.1783235. Epub 2020 Jun 25.