PMID- 32545794
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 6
DP  - 2020 Jun 13
TI  - Effects of Prolonged Type 2 Diabetes on the Inner Retinal Layer and Macular 
      Microvasculature: An Optical Coherence Tomography Angiography Study.
LID - 10.3390/jcm9061849 [doi]
LID - 1849
AB  - PURPOSE: To identify the effects of prolonged type 2 diabetes (T2DM) on macular 
      microcirculation and the inner retinal layer in diabetic eyes without clinical 
      diabetic retinopathy (DR). METHODS: 97, 92, and 57 eyes in the control, patients 
      with T2DM < 10 years (DM group one), and patients with T2DM >/= 10 years (DM group 
      two) were enrolled. The ganglion cell-inner plexiform layer (GC-IPL) thickness 
      and superficial vessel density (VD) were compared. Linear regression analyses 
      were performed to identify factors associated with VD in T2DM patients. RESULTS: 
      GC-IPL thicknesses in the control, DM group one, and DM group two were 84.58 +/- 
      0.89, 83.49 +/- 0.70, and 79.04 +/- 0.96 mum, respectively (p < 0.001). The VDs of the 
      full area were 20.32 +/- 0.15, 19.46 +/- 0.17, and 18.46 +/- 0.23 mm(-1) (p < 0.001). 
      Post-hoc analyses revealed that the VDs of the full area was significantly 
      different in the control vs. DM group one (p = 0.001), control vs. DM group two 
      (p < 0.001), and DM group one vs. DM group two (p = 0.001). Multivariate linear 
      regression analyses revealed that DM duration (p = 0.037), visual acuity (p = 
      0.013), and GC-IPL thickness (p < 0.001) were significantly associated with the 
      VD of T2DM patients. CONCLUSIONS: We confirmed GC-IPL thinning and decreased 
      superficial VD in the macular areas using OCTA in T2DM patients. Patients with 
      T2DM >/= 10 years exhibited significantly more severe macular microcirculation 
      impairment compared to patients with T2DM < 10 years and normal controls.
FAU - Lee, Min-Woo
AU  - Lee MW
AD  - Department of Ophthalmology, Konyang University College of Medicine, Daejeon 
      35365, Korea.
FAU - Lee, Woo-Hyuk
AU  - Lee WH
AUID- ORCID: 0000-0003-3133-2430
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon 35015, Korea.
FAU - Ryu, Cheon-Kuk
AU  - Ryu CK
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon 35015, Korea.
FAU - Kim, Tae-Yeon
AU  - Kim TY
AD  - Department of Ophthalmology, Konyang University College of Medicine, Daejeon 
      35365, Korea.
FAU - Lim, Hyung-Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon 35015, Korea.
FAU - Lee, Young-Hoon
AU  - Lee YH
AD  - Department of Ophthalmology, Konyang University College of Medicine, Daejeon 
      35365, Korea.
FAU - Kim, Jung-Yeul
AU  - Kim JY
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon 35015, Korea.
AD  - Department of Ophthalmology, Chungnam National University Hospital, #640 
      Daesa-dong, Jung-gu, Daejeon 301-721, Korea.
LA  - eng
PT  - Journal Article
DEP - 20200613
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7355838
OTO - NOTNLM
OT  - diabetes
OT  - ganglion cell-inner plexiform layer
OT  - optical coherence tomography angiography
OT  - vessel density
COIS- The authors declare no conflict of interest.
EDAT- 2020/06/18 06:00
MHDA- 2020/06/18 06:01
PMCR- 2020/06/13
CRDT- 2020/06/18 06:00
PHST- 2020/05/26 00:00 [received]
PHST- 2020/06/10 00:00 [revised]
PHST- 2020/06/11 00:00 [accepted]
PHST- 2020/06/18 06:00 [entrez]
PHST- 2020/06/18 06:00 [pubmed]
PHST- 2020/06/18 06:01 [medline]
PHST- 2020/06/13 00:00 [pmc-release]
AID - jcm9061849 [pii]
AID - jcm-09-01849 [pii]
AID - 10.3390/jcm9061849 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jun 13;9(6):1849. doi: 10.3390/jcm9061849.