PMID- 32545998 OWN - NLM STAT- MEDLINE DCOM- 20210702 LR - 20210702 IS - 1479-9731 (Electronic) IS - 1479-9723 (Print) IS - 1479-9723 (Linking) VI - 17 DP - 2020 Jan-Dec TI - Anxiety and depression in bronchiectasis: Response to pulmonary rehabilitation and minimal clinically important difference of the Hospital Anxiety and Depression Scale. PG - 1479973120933292 LID - 10.1177/1479973120933292 [doi] LID - 1479973120933292 AB - The aims of the study were to evaluate the responsiveness of Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale and HADS-Depression (HADS-D) subscale to pulmonary rehabilitation (PR) in patients with bronchiectasis compared to a matched group of patients with chronic obstructive pulmonary disease (COPD) and provide estimates of the minimal clinically important difference (MCID) of HADS-A and HADS-D in bronchiectasis. Patients with bronchiectasis and at least mild anxiety or depression (HADS-A >/= 8 or/and HADS-D >/= 8), as well as a propensity score-matched control group of patients with COPD, underwent an 8-week outpatient PR programme (two supervised sessions per week). Within- and between-group changes were calculated in response to PR. Anchor- and distribution-based methods were used to estimate the MCID. HADS-A and HADS-D improved in response to PR in both patients with bronchiectasis and those with COPD (median (25th, 75th centile)/mean (95% confidence interval) change: HADS-A change: bronchiectasis -2 (-5, 0), COPD -2 (-4, 0); p = 0.43 and HADS-D change: bronchiectasis -2 (-2 to -1), COPD -2 (-3 to -2); p = 0.16). Using 26 estimates, the MCID for HADS-A and HADS-D was -2 points. HADS-A and HADS-D are responsive to PR in patients with bronchiectasis and symptoms of mood disorder, with an MCID estimate of -2 points. FAU - Wynne, Stephanie C AU - Wynne SC AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Patel, Suhani AU - Patel S AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Barker, Ruth E AU - Barker RE AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - National Heart and Lung Institute, Imperial College London, London, UK. FAU - Jones, Sarah E AU - Jones SE AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - National Heart and Lung Institute, Imperial College London, London, UK. FAU - Walsh, Jessica A AU - Walsh JA AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Kon, Samantha Sc AU - Kon SS AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Department of Respiratory Medicine, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - The Hillingdon Hospitals NHS Foundation Trust, Uxbridge, UK. FAU - Cairn, Julius AU - Cairn J AD - Department of Respiratory Medicine, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Loebinger, Michael R AU - Loebinger MR AD - National Heart and Lung Institute, Imperial College London, London, UK. AD - Host Defence Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Wilson, Robert AU - Wilson R AD - National Heart and Lung Institute, Imperial College London, London, UK. AD - Host Defence Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Man, William D-C AU - Man WD AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - National Heart and Lung Institute, Imperial College London, London, UK. AD - Department of Respiratory Medicine, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. FAU - Nolan, Claire M AU - Nolan CM AUID- ORCID: 0000-0001-9067-599X AD - Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. AD - Harefield Pulmonary Rehabilitation Unit, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study PL - England TA - Chron Respir Dis JT - Chronic respiratory disease JID - 101197408 SB - IM MH - *Anxiety/diagnosis/physiopathology MH - *Bronchiectasis/diagnosis/epidemiology/psychology/rehabilitation MH - *Depression/diagnosis/physiopathology MH - Female MH - Humans MH - London/epidemiology MH - Male MH - Middle Aged MH - Minimal Clinically Important Difference MH - Outcome Assessment, Health Care MH - Psychiatric Status Rating Scales MH - *Pulmonary Disease, Chronic Obstructive/epidemiology/psychology/rehabilitation MH - *Quality of Life MH - Severity of Illness Index MH - Surveys and Questionnaires MH - Treatment Outcome PMC - PMC7301664 OTO - NOTNLM OT - Anxiety OT - bronchiectasis OT - depression OT - minimal clinically important difference OT - pulmonary rehabilitation COIS- Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2020/06/18 06:00 MHDA- 2021/07/03 06:00 PMCR- 2020/06/16 CRDT- 2020/06/18 06:00 PHST- 2020/06/18 06:00 [entrez] PHST- 2020/06/18 06:00 [pubmed] PHST- 2021/07/03 06:00 [medline] PHST- 2020/06/16 00:00 [pmc-release] AID - 10.1177_1479973120933292 [pii] AID - 10.1177/1479973120933292 [doi] PST - ppublish SO - Chron Respir Dis. 2020 Jan-Dec;17:1479973120933292. doi: 10.1177/1479973120933292.