PMID- 32547139 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220415 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 13 DP - 2020 TI - Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study. PG - 1771-1784 LID - 10.2147/DMSO.S248352 [doi] AB - PURPOSE: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including beta-cell function index (HOMA-beta), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them. MATERIALS AND AND METHODS: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants. RESULTS: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-beta, HOMA-IR, FI, FG. CONCLUSION: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors. CI - (c) 2020 Chen et al. FAU - Chen, Zefeng AU - Chen Z AUID- ORCID: 0000-0001-5497-137X AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Bai, Yulan AU - Bai Y AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Long, Xinyang AU - Long X AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Luo, Qianqian AU - Luo Q AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Wen, Zheng AU - Wen Z AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Li, Yuanfan AU - Li Y AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Huang, Shengzhu AU - Huang S AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Yan, Yunkun AU - Yan Y AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. FAU - Mo, Zengnan AU - Mo Z AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People's Republic of China. AD - Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People's Republic of China. AD - Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. LA - eng PT - Journal Article DEP - 20200522 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC7250315 OTO - NOTNLM OT - GWASs OT - Mendelian randomization OT - T2DM OT - adiponectin OT - glucose homeostasis COIS- The authors report no conflicts of interest in this work. EDAT- 2020/06/18 06:00 MHDA- 2020/06/18 06:01 PMCR- 2020/05/22 CRDT- 2020/06/18 06:00 PHST- 2020/02/04 00:00 [received] PHST- 2020/04/19 00:00 [accepted] PHST- 2020/06/18 06:00 [entrez] PHST- 2020/06/18 06:00 [pubmed] PHST- 2020/06/18 06:01 [medline] PHST- 2020/05/22 00:00 [pmc-release] AID - 248352 [pii] AID - 10.2147/DMSO.S248352 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2020 May 22;13:1771-1784. doi: 10.2147/DMSO.S248352. eCollection 2020.