PMID- 32547700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 11
IP  - 6
DP  - 2020 Jun 15
TI  - Effects of lifestyle interventions on rural patients with type 2 diabetes 
      mellitus.
PG  - 261-268
LID - 10.4239/wjd.v11.i6.261 [doi]
AB  - BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly 
      in rural areas, and lifestyle interventions can effectively reduce the blood 
      glucose levels of patients with T2DM. However, current dietary and exercise 
      guidelines are still at experimental stages and are difficult for subjects to 
      understand and implement. The Human Metabolism Analyzer provides real life 
      interventions for the prevention and treatment of T2DM, and our pilot research 
      has demonstrated its effectiveness and good compliance. AIM: To investigate the 
      effect of and compliance with lifestyle interventions in rural patients with 
      T2DM. METHODS: A total of ten rural villages were randomly selected in Chaoshui 
      Township, Penglai City, Shandong Province, China, to conduct health screening 
      among residents aged 50 years or older. Each rural village represented a group, 
      and 12 patients with T2DM were randomly selected from each group (total: 120) to 
      participate in this study and receive real life lifestyle interventions and 
      medication guidance. Lifestyle interventions included changing the meal order 
      (A), postprandial activities (B), resistance exercise (C), and reverse abdominal 
      breathing (D). Diabetes education was conducted at least once a month with a 
      weekly phone follow-up to monitor exercise and diet. Waist circumference, blood 
      pressure, body mass index (BMI), motor function, body composition, fasting blood 
      glucose, and glycated hemoglobin (HbA1c) were analyzed before and 3 mo after the 
      intervention. Moreover, patient compliance and adjustments of hypoglycemic drugs 
      were evaluated. RESULTS: A total of 109 subjects completed the study. The 
      compliance rates for lifestyle interventions A, B, C, and D were 57.79%, 60.55%, 
      64.22%, and 75.23%, respectively. Among the subjects who received hypoglycemic 
      drugs, the dose was reduced 2 to 3 times based on blood glucose in 54 (67.50%) 
      subjects and was tapered and discontinued in 5 (6.25%) subjects within 3 mo, with 
      no significant fluctuations in blood glucose after dose reduction and withdrawal. 
      After lifestyle interventions, waist circumference, BMI, fasting blood glucose, 
      and HbA1c significantly decreased (P < 0.001); motor function and body 
      composition also significantly improved (P < 0.001). CONCLUSION: For patients 
      with T2DM, compliance to real-life lifestyle interventions is good, and the 
      interventions significantly improve metabolic indicators such as waist 
      circumference, BMI, blood pressure, HbA1c, body composition, and motor function. 
      Some patients are able to taper or discontinue hypoglycemic drugs.
CI  - (c)The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Mu, Xiao-Li
AU  - Mu XL
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Zhao, Juan
AU  - Zhao J
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Jiang, Hai-Ping
AU  - Jiang HP
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Li, Shan-Shan
AU  - Li SS
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Yan, Ge
AU  - Yan G
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Hua, Ying-Ying
AU  - Hua YY
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Ren, Xue-Yi
AU  - Ren XY
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Xing, Li-Xia
AU  - Xing LX
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Liang, Yan
AU  - Liang Y
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Zhang, Shu-Dong
AU  - Zhang SD
AD  - Department of Internal Medicine, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China.
FAU - Zhao, Yu-Chi
AU  - Zhao YC
AD  - Department of Osteoarthropathy, Yantaishan Hospital, Yantai 264025, Shandong 
      Province, China. zhaoyuchizyc@163.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC7284015
OTO - NOTNLM
OT  - Body mass index
OT  - Lifestyle interventions
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: The authors have no actual or potential conflicts 
      of interest to declare.
EDAT- 2020/06/18 06:00
MHDA- 2020/06/18 06:01
PMCR- 2020/06/15
CRDT- 2020/06/18 06:00
PHST- 2019/12/26 00:00 [received]
PHST- 2020/03/30 00:00 [revised]
PHST- 2020/05/05 00:00 [accepted]
PHST- 2020/06/18 06:00 [entrez]
PHST- 2020/06/18 06:00 [pubmed]
PHST- 2020/06/18 06:01 [medline]
PHST- 2020/06/15 00:00 [pmc-release]
AID - 10.4239/wjd.v11.i6.261 [doi]
PST - ppublish
SO  - World J Diabetes. 2020 Jun 15;11(6):261-268. doi: 10.4239/wjd.v11.i6.261.