PMID- 32548715
OWN - NLM
STAT- MEDLINE
DCOM- 20210204
LR  - 20210204
IS  - 1674-8018 (Electronic)
IS  - 1674-800X (Print)
IS  - 1674-800X (Linking)
VI  - 11
IP  - 12
DP  - 2020 Dec
TI  - How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?
PG  - 881-893
LID - 10.1007/s13238-020-00739-1 [doi]
AB  - Cytokines are secreted by various cell types and act as critical mediators in 
      many physiological processes, including immune response and tumor progression. 
      Cytokines production is precisely and timely regulated by multiple mechanisms at 
      different levels, ranging from transcriptional to post-transcriptional and 
      posttranslational processes. Monocyte chemoattractant protein-1 induced protein 1 
      (MCPIP1), a potent immunosuppressive protein, was first described as a 
      transcription factor in monocytes treated with monocyte chemoattractant protein-1 
      (MCP-1) and subsequently found to possess intrinsic RNase and deubiquitinase 
      activities. MCPIP1 tightly regulates cytokines expression via various functions. 
      Furthermore, cytokines such as interleukin 1 beta (IL-1B) and MCP-1 and 
      inflammatory cytokines inducer lipopolysaccharide (LPS) strongly induce MCPIP1 
      expression. Mutually regulated MCPIP1 and cytokines form a complicated network in 
      the tumor environment. In this review, we summarize how MCPIP1 and cytokines 
      reciprocally interact and elucidate the effect of the network formed by these 
      components in cancer-related immunity with aim of exploring potential clinical 
      benefits of their mutual regulation.
FAU - Xu, Ruyi
AU  - Xu R
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China.
FAU - Li, Yi
AU  - Li Y
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China.
FAU - Qu, Jianwei
AU  - Qu J
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China.
FAU - Cao, Wen
AU  - Cao W
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China.
FAU - Zhang, Enfan
AU  - Zhang E
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China.
FAU - He, Jingsong
AU  - He J
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China. hejingsong@zju.edu.cn.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China. 
      hejingsong@zju.edu.cn.
FAU - Cai, Zhen
AU  - Cai Z
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, 310006, China. caiz@zju.edu.cn.
AD  - Institution of Hematology, Zhejiang University, Hangzhou, 310006, China. 
      caiz@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200616
PL  - Germany
TA  - Protein Cell
JT  - Protein & cell
JID - 101532368
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL1B protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 3.1.- (Ribonucleases)
RN  - EC 3.1.- (ZC3H12A protein, human)
SB  - IM
MH  - Chemokine CCL2/*immunology
MH  - Humans
MH  - Interleukin-1beta/*immunology
MH  - Neoplasm Proteins/*immunology
MH  - Neoplasms/*immunology/pathology
MH  - Ribonucleases/*immunology
MH  - Transcription Factors/*immunology
PMC - PMC7719135
OTO - NOTNLM
OT  - MCPIP1
OT  - RNase
OT  - cancer-related immunity
OT  - cytokines
OT  - deubiquitinase
EDAT- 2020/06/18 06:00
MHDA- 2021/02/05 06:00
PMCR- 2020/06/16
CRDT- 2020/06/18 06:00
PHST- 2020/04/09 00:00 [received]
PHST- 2020/05/11 00:00 [accepted]
PHST- 2020/06/18 06:00 [pubmed]
PHST- 2021/02/05 06:00 [medline]
PHST- 2020/06/18 06:00 [entrez]
PHST- 2020/06/16 00:00 [pmc-release]
AID - 10.1007/s13238-020-00739-1 [pii]
AID - 739 [pii]
AID - 10.1007/s13238-020-00739-1 [doi]
PST - ppublish
SO  - Protein Cell. 2020 Dec;11(12):881-893. doi: 10.1007/s13238-020-00739-1. Epub 2020 
      Jun 16.