PMID- 32551954
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20200803
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 71
IP  - 8
DP  - 2020 Sep
TI  - Peripheral Vascular Function in Dilated Cardiomyopathy of Different Etiology.
PG  - 726-733
LID - 10.1177/0003319720932803 [doi]
AB  - Vascular function in dilated cardiomyopathy of different etiology has been poorly 
      investigated. Moreover, reference values of flow-mediated dilation (FMD) in 
      chronic heart failure (CHF) need to be updated according to the new standardized 
      protocols. We characterized the vascular impairment in different stages of 
      post-ischemic dilated cardiomyopathy (PI-DC) or idiopathic dilated cardiomyopathy 
      (I-DC). Eighty consecutive outpatients with CHF in different New York Heart 
      Association (NYHA) classes (45 PI-DC, 35 I-DC) and 50 control subjects underwent 
      FMD and brachial distensibility coefficient measurement. Patients with CHF showed 
      a marked impairment in FMD compared with controls that worsened from classes NYHA 
      I-II to III-IV, independently of etiology (P < .05). New York Heart Association 
      I-II PI-DC patients showed a worse FMD compared with NYHA I-II I-DC patients (P < 
      .05). Brachial distensibility coefficient values were significantly lower in 
      patients with CHF compared with controls (P < .001) without differences between 
      PI-DC and I-DC. In conclusion, advanced CHF is characterized by vascular 
      impairment that is independent of etiology. In the early stages of CHF, 
      endothelial dysfunction is more severe in patients with PI-DC compared with I-DC 
      probably due to the high cardiovascular risk profile. In I-DC, vascular function 
      impairment is independent of cardiovascular risk factors and could participate in 
      the pathogenesis of I-DC.
FAU - Bosso, Giorgio
AU  - Bosso G
AUID- ORCID: 0000-0002-2759-8343
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Valvano, Antonio
AU  - Valvano A
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Apuzzi, Valentina
AU  - Apuzzi V
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Mercurio, Valentina
AU  - Mercurio V
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Di Simone, Valeria
AU  - Di Simone V
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Cittadini, Antonio
AU  - Cittadini A
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Napoli, Raffaele
AU  - Napoli R
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
FAU - Oliviero, Ugo
AU  - Oliviero U
AUID- ORCID: 0000-0001-8339-1956
AD  - Department of Translational Medical Sciences, Federico II University School of 
      Medicine, Naples, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200617
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - Aged
MH  - Brachial Artery/diagnostic imaging/*physiopathology
MH  - Cardiomyopathy, Dilated/diagnostic imaging/*etiology/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*complications/diagnosis/physiopathology
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Vascular Stiffness
MH  - *Vasodilation
OTO - NOTNLM
OT  - chronic heart failure
OT  - dilated cardiomyopathy
OT  - endothelial dysfunction
OT  - flow-mediated dilation
OT  - vascular distensibility
EDAT- 2020/06/20 06:00
MHDA- 2020/08/04 06:00
CRDT- 2020/06/20 06:00
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2020/06/20 06:00 [entrez]
AID - 10.1177/0003319720932803 [doi]
PST - ppublish
SO  - Angiology. 2020 Sep;71(8):726-733. doi: 10.1177/0003319720932803. Epub 2020 Jun 
      17.