PMID- 32555360
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20201014
LR  - 20240329
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jun 17
TI  - Advanced characterization of surface-modified nanoparticles and nanofilled 
      antibacterial dental adhesive resins.
PG  - 9811
LID - 10.1038/s41598-020-66819-8 [doi]
LID - 9811
AB  - Nanotechnology can improve the performance of dental polymers. The objective of 
      this study was to modify the surfaces of nanoparticles with silanes and proteins, 
      characterize nanoparticles' agglomeration levels and interfaces between 
      nanoparticles and the polymeric matrix. Undoped (n-TiO(2)), nitrogen-doped 
      (N_TiO(2)) and nitrogen-fluorine co-doped titanium dioxide nanoparticles 
      (NF_TiO(2)) were synthesized and subjected to surface modification procedures in 
      preparation for Small-Angle X-Ray Scattering (SAXS) and Small-Angle Neutron 
      Scattering (SANS) characterizations. Experimental adhesives were manually 
      synthesized by incorporating 20% (v/v) of n-TiO(2), N_TiO(2) or NF_TiO(2) 
      (as-synthesized or surface-modified) into OptiBond Solo Plus (OPTB). Specimens 
      (n = 15/group; d = 6.0 mm, t = 0.5 mm) of OPTB and experimental adhesives were 
      characterized using Time-of-Flight Secondary Ion Mass Spectroscopy (ToF-SIMS), 
      2-D ToF-SIMS chemical imaging and SANS. SAXS results indicated that 
      surface-modified nanoparticles displayed higher scattering intensities in a 
      particle-size dependent manner. ToF-SIMS results demonstrated that nanoparticles' 
      incorporation did not adversely impact the parental polymer. 2-D ToF-SIMS 
      chemical imaging demonstrated the distribution of Ti(+) and confirmed 
      nitrogen-doping levels. SANS results confirmed nanoparticles' functionalization 
      and revealed the interfaces between nanoparticles and the polymer matrix. 
      Metaloxide nanoparticles were successfully fabricated, incorporated and 
      covalently functionalized in a commercial dental adhesive resin, thereby 
      supporting the utilization of nanotechnology in dentistry.
FAU - Esteban Florez, Fernando Luis
AU  - Esteban Florez FL
AD  - The University of Oklahoma Health Sciences Center, Department of Restorative 
      Sciences, Division of Dental Biomaterials, College of Dentistry, 1201 N. 
      Stonewall Avenue, Oklahoma City, Oklahoma, 73117, USA. 
      fernando-esteban-florez@ouhsc.edu.
FAU - Trofimov, Artem A
AU  - Trofimov AA
AD  - Oak Ridge National Laboratory, Center for Nanophase Materials Sciences, Oak 
      Ridge, Tennessee, 37831, USA.
FAU - Ievlev, Anton
AU  - Ievlev A
AD  - Oak Ridge National Laboratory, Center for Nanophase Materials Sciences, Oak 
      Ridge, Tennessee, 37831, USA.
FAU - Qian, Shuo
AU  - Qian S
AD  - Oak Ridge National Laboratory, Neutron Scattering Division, Oak Ridge, Tennessee, 
      37831, USA.
FAU - Rondinone, Adam Justin
AU  - Rondinone AJ
AD  - Oak Ridge National Laboratory, Center for Nanophase Materials Sciences, Oak 
      Ridge, Tennessee, 37831, USA.
FAU - Khajotia, Sharukh Soli
AU  - Khajotia SS
AD  - The University of Oklahoma Health Sciences Center, Department of Restorative 
      Sciences, Division of Dental Biomaterials, College of Dentistry, 1201 N. 
      Stonewall Avenue, Oklahoma City, Oklahoma, 73117, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20200617
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
PMC - PMC7299952
COIS- The authors declare no competing interests.
EDAT- 2020/06/20 06:00
MHDA- 2020/06/20 06:01
PMCR- 2020/06/17
CRDT- 2020/06/20 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/05/21 00:00 [accepted]
PHST- 2020/06/20 06:00 [entrez]
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2020/06/20 06:01 [medline]
PHST- 2020/06/17 00:00 [pmc-release]
AID - 10.1038/s41598-020-66819-8 [pii]
AID - 66819 [pii]
AID - 10.1038/s41598-020-66819-8 [doi]
PST - epublish
SO  - Sci Rep. 2020 Jun 17;10(1):9811. doi: 10.1038/s41598-020-66819-8.